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5VBZ

Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp

Summary for 5VBZ
Entry DOI10.2210/pdb5vbz/pdb
DescriptorGTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsgtpase, inhibitor, gdp, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains3
Total formula weight59750.65
Authors
Gentile, D.R.,Jenkins, M.L.,Moss, S.M.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-30, release date: 2017-10-25, Last modification date: 2023-10-04)
Primary citationGentile, D.R.,Rathinaswamy, M.K.,Jenkins, M.L.,Moss, S.M.,Siempelkamp, B.D.,Renslo, A.R.,Burke, J.E.,Shokat, K.M.
Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Cell Chem Biol, 24:1455-1466.e14, 2017
Cited by
PubMed: 29033317
DOI: 10.1016/j.chembiol.2017.08.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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