5VBZ

Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue GNP A 201

Chain	Residue
A	GLY12
A	ASP30
A	GLU31
A	TYR32
A	THR35
A	GLY60
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	GLY13
A	ALA146
A	LYS147
A	MG202
A	HOH303
A	HOH304
A	HOH313
A	HOH316
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	THR35
A	GNP201
A	HOH303
A	HOH304

---

site_id	AC3
Number of Residues	22
Details	binding site for residue GNP B 201

Chain	Residue
B	GLY12
B	GLY13
B	VAL14
B	GLY15
B	LYS16
B	SER17
B	ALA18
B	PHE28
B	VAL29
B	ASP30
B	GLY60
B	ASN116
B	LYS117
B	ASP119
B	LEU120
B	SER145
B	ALA146
B	LYS147
B	MG202
B	HOH302
B	HOH311
C	ARG41

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 202

Chain	Residue
B	SER17
B	GNP201
B	HOH302
B	HOH311
B	HOH316

---

site_id	AC5
Number of Residues	18
Details	binding site for residue GNP C 302

Chain	Residue
C	GLY12
C	GLY13
C	VAL14
C	GLY15
C	LYS16
C	SER17
C	ALA18
C	PHE28
C	THR35
C	GLY60
C	ASN116
C	LYS117
C	ASP119
C	SER145
C	ALA146
C	LYS147
C	MG303
C	HOH406

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG C 303

Chain	Residue
C	SER17
C	THR35
C	GNP302
C	HOH406

---

site_id	AC7
Number of Residues	13
Details	binding site for Di-peptide 92V C 301 and CYS C 72

Chain	Residue
C	ARG41
C	GLN43
C	ARG68
C	ASP69
C	GLN70
C	TYR71
C	ARG73
C	THR74
C	GLY75
C	PHE78
C	GLN95
C	TYR96
C	GLN99

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269|PubMed:16698776

Chain	Residue	Details
A	GLY13
B	SER145
C	GLY13
C	VAL29
C	ALA59
C	ASN116
C	SER145
A	VAL29
A	ALA59
A	ASN116
A	SER145
B	GLY13
B	VAL29
B	ALA59
B	ASN116

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12

Chain	Residue	Details
A	MET1
B	MET1
C	MET1

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12

Chain	Residue	Details
A	THR2
B	THR2
C	THR2

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151

Chain	Residue	Details
A	CYS118
B	CYS118
C	CYS118

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667

Chain	Residue	Details
A	THR35
B	THR35
C	THR35

---