5VBZ
Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | GTPase HRas | polymer | 171 | 19250.6 | 3 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (Human) | H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras |
| 2 | D, F, I (A, B, C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 3 | Chemie (GNP) | |||
| 3 | E, G, J (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | H (C) | 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | non-polymer | 359.4 | 1 | Chemie (92V) | |||
| 5 | K, L, M (A, B, C) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 166 (UniProt: P01112)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Cys 72 | Met 72 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57751.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1998.9 | |
| All* | Total formula weight | 59750.7 |
