5VBE
Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GDP
Summary for 5VBE
Entry DOI | 10.2210/pdb5vbe/pdb |
Related | 5VBM |
Descriptor | GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, ... (5 entities in total) |
Functional Keywords | gtpase, inhibitor, gdp, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20077.47 |
Authors | Gentile, D.R.,Jenkins, M.L.,Moss, S.M.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-29, release date: 2017-10-25, Last modification date: 2023-10-04) |
Primary citation | Gentile, D.R.,Rathinaswamy, M.K.,Jenkins, M.L.,Moss, S.M.,Siempelkamp, B.D.,Renslo, A.R.,Burke, J.E.,Shokat, K.M. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol, 24:1455-1466.e14, 2017 Cited by PubMed: 29033317DOI: 10.1016/j.chembiol.2017.08.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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