8WF4
| The Crystal Structure of RSK1 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, Ribosomal protein S6 kinase alpha-1 | 著者 | Wang, F, Cheng, W, Lv, Z, Qi, J, Li, J. | 登録日 | 2023-09-19 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The Crystal Structure of RSK1 from Biortus. To Be Published
|
|
8JUP
| |
8JUV
| |
8WJY
| PKMYT1_Cocrystal_Cpd 4 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ... | 著者 | Wang, Y, Wang, C, Liu, T, Qi, H, Chen, S, Cai, X, Zhang, M, Aliper, A, Ren, F, Ding, X, Zhavoronkov, A. | 登録日 | 2023-09-26 | 公開日 | 2023-11-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer. J.Med.Chem., 67, 2024
|
|
8WGF
| The Crystal Structure of JNK3 from Biortus. | 分子名称: | MAGNESIUM ION, Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | 登録日 | 2023-09-21 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The Crystal Structure of JNK3 from Biortus. To Be Published
|
|
8JF4
| The crystal structure of human AURKA kinase domain in complex with AURKA-compound 9 | 分子名称: | 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-N-prop-2-ynyl-pyrimidine-4-carboxamide, Aurora kinase A | 著者 | Zhu, C.J. | 登録日 | 2023-05-17 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.89288354 Å) | 主引用文献 | Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
8X5Z
| |
5W4W
| |
5W5Q
| MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide) | 分子名称: | (5s,7s)-N~3~-methyl-10-[3-methyl-3-(5-methyl-1,3-oxazol-2-yl)but-1-yn-1-yl]-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase kinase 4 | 著者 | Harris, S.F, Wu, P. | 登録日 | 2017-06-15 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1). Acs Med.Chem.Lett., 10, 2019
|
|
8X88
| |
8X72
| The Crystal Structure of PLK1 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Wu, B. | 登録日 | 2023-11-22 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Crystal Structure of PLK1 from Biortus. To Be Published
|
|
8T2H
| DYRK1A complex with DYR530 | 分子名称: | (4P)-4-{(3M)-3-[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]-2-methyl-3H-imidazo[4,5-b]pyridin-5-yl}pyridin-2-amine, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL, ... | 著者 | Montfort, W.R, Basantes, L.E. | 登録日 | 2023-06-06 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of DYR684, a Potent, Selective, Metabolically Stable, DYRK1A/B PROTAC utilizing a Novel Cereblon Molecular Glue To Be Published
|
|
8X23
| The Crystal Structure of MAPK13 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Mitogen-activated protein kinase 13 | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Pan, W. | 登録日 | 2023-11-09 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The Crystal Structure of MAPK13 from Biortus. To Be Published
|
|
8XFM
| The Crystal Structure of MNK2 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, 5-(3-azanyl-1~{H}-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one, MAP kinase-interacting serine/threonine-protein kinase 2, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | 登録日 | 2023-12-14 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The Crystal Structure of MNK2 from Biortus. To Be Published
|
|
8X5L
| The Crystal Structure of PRKACA from Biortus. | 分子名称: | (2S)-2-(4-chlorophenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)phenyl]ethanaminium, SODIUM ION, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Wang, F, Cheng, W, Lv, Z, Lin, D, Pan, W. | 登録日 | 2023-11-17 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The Crystal Structure of PRKACA from Biortus. To Be Published
|
|
5WNM
| |
8X5M
| The Crystal Structure of JNK1 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, 3-[4-(dimethylamino)butanoylamino]-~{N}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide, GLYCEROL, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | 登録日 | 2023-11-17 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The Crystal Structure of JNK1 from Biortus. To Be Published
|
|
8XN6
| The Crystal Structure of GSK3b from Biortus. | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Glycogen synthase kinase-3 beta, ... | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Wu, B. | 登録日 | 2023-12-29 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The Crystal Structure of GSK3b from Biortus. To Be Published
|
|
5X1R
| PpkA-294 apo form | 分子名称: | PpkA-294 | 著者 | Li, P.P, Ran, T.T, Xu, D.Q, Wang, W.W. | 登録日 | 2017-01-26 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism. Biochem.J., 475, 2018
|
|
8U2O
| |
8XU4
| The Crystal Structure of MAPK2 from Biortus. | 分子名称: | MALONIC ACID, MAP kinase-activated protein kinase 2 | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z. | 登録日 | 2024-01-12 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | The Crystal Structure of MAPK2 from Biortus. To Be Published
|
|
8XPZ
| The Crystal Structure of TTBK1 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, Tau-tubulin kinase 1 | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Ni, C. | 登録日 | 2024-01-04 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The Crystal Structure of TTBK1 from Biortus. To Be Published
|
|
8JG8
| |
5WE8
| |
5WJJ
| Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | 分子名称: | Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide | 著者 | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | 登録日 | 2017-07-23 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
|
|