7M0M

HPK1 IN COMPLEX WITH COMPOUND 1

Summary for 7M0M

• Entry DOI: 10.2210/pdb7m0m/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide (3 entities in total)
• Functional Keywords: hpk1 hematopoietic progenitor kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 66783.32

Authors

Lesburg, C.A. (deposition date: 2021-03-11, release date: 2021-04-07, Last modification date: 2024-04-03)

• Primary citation: Vara, B.A.,Levi, S.M.,Achab, A.,Candito, D.A.,Fradera, X.,Lesburg, C.A.,Kawamura, S.,Lacey, B.M.,Lim, J.,Methot, J.L.,Xu, Z.,Xu, H.,Smith, D.M.,Piesvaux, J.A.,Miller, J.R.,Bittinger, M.,Ranganath, S.H.,Bennett, D.J.,DiMauro, E.F.,Pasternak, A.; Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.; Acs Med.Chem.Lett., 12:653-661, 2021; PubMed: 33859804; DOI: 10.1021/acsmedchemlett.1c00096

Experimental method

X-RAY DIFFRACTION (1.93 Å)