7M0M
HPK1 IN COMPLEX WITH COMPOUND 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 293 | 32901.2 | 2 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (Human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | C, D (A, B) | 4-[2-fluoro-6-(trifluoromethyl)anilino]-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide | non-polymer | 490.5 | 2 | Chemie (YK1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 294 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Glu 165 | Thr 165 | conflict |
| Glu 171 | Ser 171 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65802.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 980.9 | |
| All* | Total formula weight | 66783.3 |
