PDB: 245663 件ウェブページステータス検索Chemie searchBIRD

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1TAM	HUMAN IMMUNODEFICIENCY VIRUS, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: HIV-1 MATRIX PROTEIN 著者 Matthews, S, Barlow, P, Clark, N, Kingsman, S, Kingsman, A, Campbell, I. 登録日 1996-02-07 公開日 1996-07-11 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Refined solution structure of p17, the HIV matrix protein. Biochem.Soc.Trans., 23, 1995
4CCV	Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: Implications for the regulation of angiogenesis 分子名称: GLUTATHIONE, GLYCEROL, HISTIDINE-RICH GLYCOPROTEIN, ... 著者 McMahon, S.A, Kassaar, O, Stewart, A.J, Naismith, J.H. 登録日 2013-10-29 公開日 2014-02-19 最終更新日 2025-04-09 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Crystal Structure of Histidine-Rich Glycoprotein N2 Domain Reveals Redox Activity at an Interdomain Disulfide Bridge: Implications for Angiogenic Regulation. Blood, 123, 2014
6BNS	STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC co-activator peptide and Compound 25a AKA BICYCLIC HEXAFLUOROISOPROPYL 2 ALCOHOL SULFONAMIDES 分子名称: 2-[(2S)-4-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 Chimera 著者 DHAR, T.G, GONG, H, WEINSTEIN, D.S, LU, Z, DUAN, J.J.W, STACHURA, S, HAQUE, L, KARMAKAR, A, HEMAGIRI, H, RAUT, D.K, GUPTA, A.K, KHAN, J.A, SACK, J.S, CAMAC, D.M, PUDZIANOWSKI, A.A, WU, D.R, YARDE, M, SHEN, D.R, BOROWSKI, V, XIE, J.H, SUN, H, ARIENZO, C.D, DABROS, M, GALELLA, M.A, WANG, F, WEIGELT, C.A, ZHAO, Q, FOSTER, W, SOMERVILLE, J.E, SALTER-CID, L.M, BARRISH, J.C, CARTER, P.H. 登録日 2017-11-17 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (ROR gamma /RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity. Bioorg. Med. Chem. Lett., 28, 2018
2GK7	Structural and Functional insights into the human Upf1 helicase core 分子名称: PHOSPHATE ION, Regulator of nonsense transcripts 1 著者 Cheng, Z, Muhlrad, D, Parker, R, Song, H. 登録日 2006-03-31 公開日 2007-01-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and functional insights into the human Upf1 helicase core Embo J., 26, 2007
2ADO	Crystal Structure Of The Brct Repeat Region From The Mediator of DNA damage checkpoint protein 1, MDC1 分子名称: Mediator of DNA damage checkpoint protein 1 著者 Lee, M.S, Edwards, R.A, Thede, G.L, Glover, J.N. 登録日 2005-07-20 公開日 2005-08-02 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of the BRCT Repeat Domain of MDC1 and Its Specificity for the Free COOH-terminal End of the {gamma}-H2AX Histone Tail. J.Biol.Chem., 280, 2005
3RGO	Crystal Structure of PTPMT1 分子名称: Protein-tyrosine phosphatase mitochondrial 1, SULFATE ION 著者 Xiao, J, Engel, J.L. 登録日 2011-04-08 公開日 2011-07-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.928 Å) 主引用文献 Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc.Natl.Acad.Sci.USA, 108, 2011
2NRY	Crystal structure of IRAK-4 分子名称: STAUROSPORINE, interleukin-1 receptor-associated kinase 4 著者 Wang, Z, Liu, J, Walker, N.P.C. 登録日 2006-11-02 公開日 2006-12-12 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper. Structure, 14, 2006
7JXF	E. coli TSase complex with a bi-substrate reaction intermediate diastereomer analog 分子名称: (2S)-2-({4-[({(6S)-2,4-diamino-5-[(1-{(2R,4S,5R)-4-hydroxy-5-[(phosphonooxy)methyl]tetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl}methyl)amino]benzoyl}amino)pentanedioic acid (non-preferred name), 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, N-[4-({[(6S)-2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methyl}amino)benzene-1-carbonyl]-L-glutamic acid, ... 著者 Finer-Moore, J, Kholodar, S.A, Stroud, R.M, Kohen, A, Moliner, V, Swiderek, K. 登録日 2020-08-27 公開日 2021-04-21 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry, 60, 2021
2GVJ	Crystal Structure of Human NMPRTase in complex with FK866 分子名称: (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase 著者 Khan, J.A, Tao, X, Tong, L. 登録日 2006-05-02 公開日 2006-06-20 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat.Struct.Mol.Biol., 13, 2006
6JR8	Flavobacterium johnsoniae GH31 dextranase, FjDex31A, mutant D412A complexed with isomaltotriose 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Candidate alpha-glycosidase Glycoside hydrolase family 31, ... 著者 Tonozuka, T. 登録日 2019-04-02 公開日 2019-04-24 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into polysaccharide recognition by Flavobacterium johnsoniae dextranase, a member of glycoside hydrolase family 31. Febs J., 287, 2020
1AKS	CRYSTAL STRUCTURE OF THE FIRST ACTIVE AUTOLYSATE FORM OF THE PORCINE ALPHA TRYPSIN 分子名称: ALPHA TRYPSIN, CALCIUM ION 著者 Johnson, A, Krishnaswamy, S, Sundaram, P.V, Pattabhi, V. 登録日 1996-07-24 公開日 1997-02-12 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The first structure at 1.8 A resolution of an active autolysate form of porcine alpha-trysoin. Acta Crystallogr.,Sect.D, 53, 1997
1JLD	Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere 分子名称: (2S)-2-tert-butyl-N~4~-(1-ethylpropyl)-N~1~-[(2R,3S)-2-hydroxy-4-phenyl-3-{[N-(quinolin-2-ylcarbonyl)-L-threonyl]amino}butyl]butanediamide, Pol polyprotein 著者 Tong, L. 登録日 1997-05-31 公開日 1997-12-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere. J.Med.Chem., 40, 1997
1PXH	Crystal structure of protein tyrosine phosphatase 1B with potent and selective bidentate inhibitor compound 2 分子名称: ACETIC ACID, MAGNESIUM ION, N-{1-[5-(1-CARBAMOYL-2-MERCAPTO-ETHYLCARBAMOYL)-PENTYLCARBAMOYL]-2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ETHYL}-3-{2-[4-(DIFLUORO-PHOSPHONO-METHYL)-PHENYL]-ACETYLAMINO}-SUCCINAMIC ACID, ... 著者 Sun, J.P, Fedorov, A, Lee, S.Y, Guo, X.L, Shen, K, Lawrence, D.S, Almo, S.C, Zhang, Z.Y. 登録日 2003-07-04 公開日 2003-08-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor. J.Biol.Chem., 278, 2003
4ITO	Human CA II inhibition by novel sulfonamide 分子名称: 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Aggarwal, M, McKenna, R. 登録日 2013-01-18 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.162 Å) 主引用文献 Human CA II inhibition by novel sulfonamide To be Published
2L6S	Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide 分子名称: VIR-576 著者 Forssmann, W, The, Y, Stoll, M, Adermann, K, Albrecht, U, Barlos, K, Busmann, A, Canales-Mayordomo, A, Gimenez-Gallego, G, Hirsch, J, Jimenez-Barbero, J, Meyer-Olson, D, Muench, J, Perez-Castells, J, Standker, L, Kirchhoff, F, Schmidt, R.E. 登録日 2010-11-24 公開日 2011-01-19 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide. Sci Transl Med, 2, 2010
7W5O	Crystal structure of ERK2 with an allosteric inhibitor 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 13-[4-({Imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-4,8-dioxa-12,14,16,18-tetraazatetracyclo[9.7.0.0^{3,9}.0^{12,17}]octadeca-1(11),2,9,15,17-pentaen-15-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Yoshida, M, Kinoshita, T. 登録日 2021-11-30 公開日 2022-02-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Identification of a novel target site for ATP-independent ERK2 inhibitors. Biochem.Biophys.Res.Commun., 593, 2022
2GKP	Protein of Unknown Function NMB0488 from Neisseria meningitidis 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, SODIUM ION, ... 著者 Osipiuk, J, Volkart, L, Bargassa, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2006-04-03 公開日 2006-05-02 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 X-ray crystal structure of hypothetical protein NMB0488 from Neisseria meningitidis. To be Published
4FV2	Crystal Structure of the ERK2 complexed with EK5 分子名称: 1,2-ETHANEDIOL, 4-[4-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(2,3-dihydro-1-benzofuran-5-ylmethyl)-1H-pyrrole-2-carboxamide, GLYCEROL, ... 著者 Kang, Y.N, Stuckey, J.A, Xie, X. 登録日 2012-06-29 公開日 2012-08-29 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the ERK2 complexed with EK5 TO BE PUBLISHED
1XH8	Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants 分子名称: N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... 著者 Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. 登録日 2004-09-17 公開日 2005-09-17 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
2ZVQ	Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and alpha-naphthol 分子名称: 1-NAPHTHOL, ADENOSINE-3'-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Teramoto, T, Sakakibara, Y, Liu, M.-C, Suiko, M, Kimura, M, Kakuta, Y. 登録日 2008-11-14 公開日 2008-12-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural basis for the broad range substrate specificity of a novel mouse cytosolic sulfotransferase--mSULT1D1 Biochem.Biophys.Res.Commun., 379, 2009
3PL0	Crystal structure of a bsmA homolog (Mpe_A2762) from Methylobium petroleophilum PM1 at 1.91 A resolution 分子名称: CHLORIDE ION, GLYCEROL, Uncharacterized protein 著者 Joint Center for Structural Genomics (JCSG) 登録日 2010-11-12 公開日 2010-12-08 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site. Proteins, 82, 2014
3W3M	Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2 分子名称: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... 著者 Tanji, H, Ohto, U, Shimizu, T. 登録日 2012-12-22 公開日 2013-04-03 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands Science, 339, 2013
2AMV	THE STRUCTURE OF GLYCOGEN PHOSPHORYLASE B WITH AN ALKYL-DIHYDROPYRIDINE-DICARBOXYLIC ACID 分子名称: 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), ... 著者 Zographos, S.E, Oikonomakos, N.G, Johnson, L.N. 登録日 1998-10-13 公開日 1998-10-21 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure, 5, 1997
2BHE	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE 分子名称: (2Z)-5'-BROMO-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE AMMONIATE, CELL DIVISION PROTEIN KINASE 2 著者 Schaefer, M, Jautelat, R, Brumby, T, Briem, H, Eisenbrand, G, Schwahn, S, Krueger, M, Luecking, U, Prien, O, Siemeister, G. 登録日 2005-01-10 公開日 2005-03-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 From the Insoluble Dye Indirubin Towards Highly Active, Soluble Cdk2-Inhibitors Chembiochem, 6, 2005
3H0A	Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist 分子名称: 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid, Nuclear receptor coactivator 1, Co-activator Peptide, ... 著者 Wang, Z, Sudom, A, Walker, N.P. 登録日 2009-04-08 公開日 2009-06-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. Bioorg.Med.Chem.Lett., 19, 2009

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