PDB: 68717 件ウェブページステータス検索Chemie searchBIRD

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4UCU	Fragment bound to H.influenza NAD dependent DNA ligase 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 8-hydroxyquinoline-2-carboxylic acid, DNA LIGASE 著者 Hale, M, Brassington, C, Carcanague, D, Embrey, K, Eyermann, C.J, Giacobbe, R.A, Gingipali, L, Gowravaram, M, Harang, J, Howard, T, Ioannidis, G, Jahic, H, Kutschke, A, Laganas, V.A, Loch, J, Miller, M.D, Murphy-Benenato, K.E, Oguto, H, Otterbein, L, Patel, S.J, Shapiro, A.B, Boriack-Sjodin, P.A. 登録日 2014-12-04 公開日 2015-10-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 From Fragments to Leads: Novel Bacterial Nad+-Dependent DNA Ligase Inhibitors Tetrahedron Lett., 56, 2015
4LMZ	Structural insight into RNA recognition by RRM1+2 domain of human ETR-3 protein 分子名称: CUGBP Elav-like family member 2, RNA (5'-R(*GP*CP*UP*GP*CP*GP*UP*AP*UP*UP*GP*UP*UP*UP*G)-3') 著者 Bhatt, H, Manickam, Y, Bhavesh, N.S. 登録日 2013-07-11 公開日 2014-07-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 sequence specific RNA recognition of ETR3 RRM 1-2 domains TO BE PUBLISHED
6P1O	Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated dAMP 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. 登録日 2019-05-20 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
4TXN	Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with 5-fluorouracil 分子名称: 5-FLUOROURACIL, SULFATE ION, Uridine phosphorylase 著者 Marinho, A, Torini, J, Romanello, L, Cassago, A, DeMarco, R, Brandao-Neto, J, Pereira, H.M. 登録日 2014-07-03 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Analysis of two Schistosoma mansoni uridine phosphorylases isoforms suggests the emergence of a protein with a non-canonical function. Biochimie, 125, 2016
3K2E	Crystal structure of enoyl-(acyl-carrier-protein) reductase from Anaplasma phagocytophilum at 1.9A resolution 分子名称: 1,2-ETHANEDIOL, Enoyl-(Acyl-carrier-protein) reductase, GLYCEROL 著者 Abendroth, J, Staker, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-09-30 公開日 2009-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of enoyl-(acyl-carrier-protein) reductase from Anaplasma phagocytophilum at 1.9A resolution To be Published
5JPC	Joint X-ray/neutron structure of MTAN complex with Formycin A 分子名称: (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, Aminodeoxyfutalosine nucleosidase 著者 Banco, M.T, Kovalevsky, A.Y, Ronning, D.R. 登録日 2016-05-03 公開日 2016-11-16 最終更新日 2024-03-06 実験手法 NEUTRON DIFFRACTION (2.5 Å), X-RAY DIFFRACTION 主引用文献 Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
1CN4	ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR 分子名称: PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN) 著者 Stroud, R.M, Reid, S.W. 登録日 1999-05-25 公開日 1999-08-11 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395, 1998
5JV0	Crystal structure of human FPPS in complex with an allosteric inhibitor CL-08-038 分子名称: Farnesyl pyrophosphate synthase, SULFATE ION, [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid 著者 Park, J, Leung, C.Y, Tsantrizos, Y.S, Berghuis, A.M. 登録日 2016-05-10 公開日 2017-03-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60, 2017
6PAC	E. coli L-asparaginase II in complex with L-Asp at pH 5.6 分子名称: ASPARTIC ACID, IMIDAZOLE, L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-06-11 公開日 2019-09-04 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Geometric considerations support the double-displacement catalytic mechanism of l-asparaginase. Protein Sci., 28, 2019
3O1F	P1 crystal form of E. coli ClpS at 1.4 A resolution 分子名称: ATP-dependent Clp protease adapter protein clpS 著者 Roman-Hernandez, G, Hou, J.Y, Grant, R.A, Sauer, R.T, Baker, T.A. 登録日 2010-07-21 公開日 2011-07-27 最終更新日 2025-03-26 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease. Mol.Cell, 43, 2011
6U18	Directed evolution of a biosensor selective for the macrolide antibiotic clarithromycin 分子名称: CITRATE ANION, CLARITHROMYCIN, Erythromycin resistance repressor protein 著者 Li, Y, Reed, M, Wright, H.T, Cropp, T.A, Williams, G. 登録日 2019-08-15 公開日 2020-08-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics. Acs Synth Biol, 2021
6PJX	Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM) 分子名称: CALCIUM ION, Calmodulin, G protein-coupled receptor kinase 5, ... 著者 Bhardwaj, A, Komolov, K.E, Sulon, S, Benovic, J.L. 登録日 2019-06-28 公開日 2020-12-09 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Mol.Cell, 81, 2021
4LHO	Crystal Structure of FG41Malonate Semialdehyde Decarboxylase inhibited by 3-bromopropiolate 分子名称: 3-chloro-3-oxopropanoic acid, FG41 Malonate Semialdehyde Decarboxylase, PHOSPHATE ION 著者 Guo, Y, Serrano, H, Poelarends, G.J, Johnson Jr, W.H, Hackert, M.L, Whitman, C.P. 登録日 2013-07-01 公開日 2013-07-24 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.224 Å) 主引用文献 Kinetic, Mutational, and Structural Analysis of Malonate Semialdehyde Decarboxylase from Coryneform Bacterium Strain FG41: Mechanistic Implications for the Decarboxylase and Hydratase Activities. Biochemistry, 52, 2013
4LKT	Crystal Structure of Human Epidermal Fatty Acid Binding Protein (FABP5) in Complex with Linoleic Acid 分子名称: AMMONIUM ION, CHLORIDE ION, CITRIC ACID, ... 著者 Armstrong, E.H, Ortlund, E.A. 登録日 2013-07-08 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor beta / delta (FABP5-PPAR beta / delta ) signaling pathway. J.Biol.Chem., 289, 2014
3JS5	Crystal structure of protein tyrosine phosphatase from Entamoeba histolytica with Hepes in the active site. High resolution, alternative crystal form with 1 molecule in asymmetric unit 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein tyrosine phosphatase, SODIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2009-09-09 公開日 2009-09-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase. Mol.Biochem.Parasitol., 193, 2014
5JX4	Crystal structure of E36-G37del mutant of the Bacillus caldolyticus cold shock protein. 分子名称: Cold shock protein CspB, SULFATE ION 著者 Carvajal, A, Castro-Fernandez, V, Cabrejos, D, Fuentealba, M, Pereira, H.M, Vallejos, G, Cabrera, R, Garratt, R.C, Komives, E.A, Ramirez-Sarmiento, C.A, Babul, J. 登録日 2016-05-12 公開日 2017-05-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics. FEBS J., 284, 2017
5KBL	Candida Albicans Superoxide Dismutase 5 (SOD5), E110Q Mutant 分子名称: COPPER (I) ION, Cell surface Cu-only superoxide dismutase 5, SULFATE ION 著者 Galaleldeen, A, Peterson, R.L, Villarreal, J, Taylor, A.B, Hart, P.J. 登録日 2016-06-03 公開日 2016-08-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.414 Å) 主引用文献 The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases. J.Biol.Chem., 291, 2016
8AIP	Crystal Structure of Two-domain bacterial laccase from the actinobacterium Streptomyces carpinensis VKM Ac-1300 分子名称: COPPER (II) ION, OXYGEN MOLECULE, Two-Domain Laccase 著者 Gabdulkhakov, A.G, Tishchenko, T.V, Trubitsina, L, Trubitsin, I, Leontievsky, A, Lisov, A. 登録日 2022-07-27 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 A Novel Two-Domain Laccase with Middle Redox Potential: Physicochemical and Structural Properties. Biochemistry Mosc., 88, 2023
3SO0	Crystal structure of a mutant T41S of a betagamma-crystallin domain from Clostridium beijerinckii 分子名称: CALCIUM ION, Clostrillin 著者 Srivastava, S.S, Sankaranarayanan, R. 登録日 2011-06-29 公開日 2011-11-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Decoding the molecular design principles underlying Ca(2+) binding to beta gamma-crystallin motifs J.Mol.Biol., 415, 2012
5KEG	Crystal structure of APOBEC3A in complex with a single-stranded DNA 分子名称: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ... 著者 Kouno, T, Hilbert, B.J, Silvas, T, Royer, W.E, Matsuo, H, Schiffer, C.A. 登録日 2016-06-09 公開日 2017-05-10 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity. Nat Commun, 8, 2017
3SDW	Crystal structure of a ribose-5-phosphate isomerase B RpiB from Coccidioides immitis bound to phosphate 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-06-09 公開日 2011-06-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis. Bmc Struct.Biol., 11, 2011
3O7M	1.98 Angstrom resolution crystal structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-2) from Bacillus anthracis str. 'Ames Ancestor' 分子名称: BETA-MERCAPTOETHANOL, GLYCEROL, Hypoxanthine phosphoribosyltransferase, ... 著者 Halavaty, A.S, Minasov, G, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-07-30 公開日 2010-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 1.98 Angstrom resolution crystal structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-2) from Bacillus anthracis str. 'Ames Ancestor' TO BE PUBLISHED
5JQ5	Crystal structure of CDK2 in complex with inhibitor ICEC0942 分子名称: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, ACETATE ION, Cyclin-dependent kinase 2 著者 Hazel, P, Freemont, P.S. 登録日 2016-05-04 公開日 2017-02-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem, 12, 2017
5JQ8	Crystal structure of CDK2 in complex with inhibitor ICEC0943 分子名称: (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, Cyclin-dependent kinase 2 著者 Hazel, P, Freemont, P.S. 登録日 2016-05-04 公開日 2017-02-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem, 12, 2017
4LPW	Crystal structure of TENCON variant A6 分子名称: TENCON variant A6 著者 Teplyakov, A, Obmolova, G, Gilliland, G.L. 登録日 2013-07-16 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold. Proteins, 82, 2014

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