PDB: 66478 件ウェブページステータス検索Chemie searchBIRD

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6V35	Cryo-EM structure of Ca2+-free hsSlo1-beta4 channel complex 分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... 著者 Tao, X, MacKinnon, R. 登録日 2019-11-25 公開日 2019-12-25 最終更新日 2020-10-07 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Molecular structures of the human Slo1 K + channel in complex with beta 4. Elife, 8, 2019
5FYE	Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, ... 著者 Alphey, M.S, Tran, F, Westwood, N.J, Naismith, J.H. 登録日 2016-03-07 公開日 2017-03-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Allosteric Competitive Inhibitors of the Glucose-1-Phosphate Thymidylyltransferase (Rmla) from Pseudomonas Aeruginosa. To be Published
2Y6V	Peroxisomal alpha-beta-hydrolase Lpx1 (Yor084w) from Saccharomyces cerevisiae (crystal form I) 分子名称: PEROXISOMAL MEMBRANE PROTEIN LPX1, PHOSPHATE ION 著者 Thoms, S, Niemann, H.H. 登録日 2011-01-26 公開日 2011-07-13 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 The Unusual Extended C-Terminal Helix of the Peroxisomal Alpha-Beta-Hydrolase Lpx1 is Involved in Dimer Contacts But Dispensable for Dimerization J.Struct.Biol., 175, 2011
4MVW	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433) 分子名称: 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
6V22	Cryo-EM structure of Ca2+-bound hsSlo1-beta4 channel complex 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Tao, X, MacKinnon, R. 登録日 2019-11-22 公開日 2019-12-25 最終更新日 2020-10-07 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Molecular structures of the human Slo1 K + channel in complex with beta 4. Elife, 8, 2019
6V2C	Complex of mutant (K162M) of E. coli L-asparaginase II with L-Asp. Covalent acyl-enzyme intermediate and tetrahedral intermediate 分子名称: L-asparaginase 2 著者 Lubkowski, J, Wlodawer, A. 登録日 2019-11-22 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanism of Catalysis by l-Asparaginase. Biochemistry, 59, 2020
4N9K	crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine 分子名称: 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase 著者 Pan, X, Wong, W, Zhao, Y. 登録日 2013-10-21 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 53, 2014
5FBN	BTK kinase domain with inhibitor 1 分子名称: 1,2-ETHANEDIOL, 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, 4-[8-azanyl-3-[(3~{R})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide, ... 著者 Raaijmakers, H.C.A, Vu-Pham, D. 登録日 2015-12-14 公開日 2016-02-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. Acs Med.Chem.Lett., 7, 2016
4MWC	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[(2-methyl-1-benzothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1540) 分子名称: 1-(3-{[(2-methyl-1-benzothiophen-3-yl)methyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. 登録日 2013-09-24 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.649 Å) 主引用文献 Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
5FU8	Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, ... 著者 Alphey, M.S, Tran, F, Westwood, N.J, Naismith, J.H. 登録日 2016-01-21 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Allosteric Competitive Inhibitors of the Glucose-1-Phosphate Thymidylyltransferase (Rmla) from Pseudomonas Aeruginosa. To be Published
4N92	Crystal structure of beta-lactamse PenP_E166S 分子名称: Beta-lactamase 著者 Pan, X, Wong, W, Zhao, Y. 登録日 2013-10-19 公開日 2014-09-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 53, 2014
5EO3	Crystal Structure of Pelota C terminal domain from human 分子名称: Protein pelota homolog 著者 Zhang, L, Cai, Q, Lin, T. 登録日 2015-11-10 公開日 2016-11-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Purification, crystallization and crystallographic analysis of the Pelota C terminal domian from human to be published
3ONM	Effector binding Domain of LysR-Type transcription factor RovM from Y. pseudotuberculosis 分子名称: Transcriptional regulator LrhA 著者 Quade, N, Diekmann, M, Haffke, M, Heroven, A.K, Dersch, P, Heinz, D.W. 登録日 2010-08-30 公開日 2011-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis. Acta Crystallogr.,Sect.D, 67, 2011
5H08	Human PTPRZ D1 domain complexed with NAZ2329 分子名称: 3-{[2-Ethoxy-5-(trifluoromethyl)benzyl]sulfanyl}-N-(phenylsulfonyl)thiophene-2-carboxamide, Receptor-type tyrosine-protein phosphatase zeta 著者 Sugawara, H. 登録日 2016-10-04 公開日 2017-07-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells Sci Rep, 7, 2017
3MEB	Structure of cytoplasmic aspartate aminotransferase from giardia lamblia 分子名称: 1,2-ETHANEDIOL, Aspartate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-03-31 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia. Acta Crystallogr F Struct Biol Commun, 71, 2015
5HBL	Native rhodanese domain of YgaP prepared with 1mM DDT is S-nitrosylated 分子名称: Inner membrane protein YgaP 著者 Eichmann, C, Tzitzilonis, C, Nakamura, T, Kwiatkowski, W, Maslennikov, I, Choe, S, Lipton, S.A, Riek, R. 登録日 2015-12-31 公開日 2016-08-10 最終更新日 2021-09-08 実験手法 X-RAY DIFFRACTION (1.617 Å) 主引用文献 S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein. J.Mol.Biol., 428, 2016
5EEC	Crystal structure of KPC-2 beta-lactamase in complex with the S02030 boronic acid inhibitor 分子名称: 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, SULFATE ION 著者 Nguyen, N.Q, van den Akker, F. 登録日 2015-10-22 公開日 2016-02-03 最終更新日 2016-03-09 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030. Antimicrob.Agents Chemother., 60, 2016
4LJM	Crystal structure of C-terminal RNA recognition motif of human ETR3 分子名称: CUGBP Elav-like family member 2 著者 Kashyap, M, Sharma, A, Yogavel, M, Bhavesh, N.S. 登録日 2013-07-05 公開日 2014-07-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of C-terminal RNA recognition motif of human ETR3 To be Published
6OG0	Structure of Aedes aegypti OBP22 分子名称: AAEL005772-PA, CADMIUM ION, CHLORIDE ION 著者 Jones, D.N, Wang, J. 登録日 2019-04-01 公開日 2019-04-17 最終更新日 2020-05-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail. Sci Rep, 10, 2020
4KYX	Crystal structure of ADP-ribose pyrophosphatase MutT from Rickettsia felis 分子名称: ADP-ribose pyrophosphatase MutT 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-05-29 公開日 2013-08-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of ADP-ribose pyrophosphatase MutT from Rickettsia felis To be Published
5G1Q	Compressed conformation of Francisella tularensis ClpP at 2.84 A 分子名称: CLP PROTEASE PROTEOLYTIC SUBUNIT P 著者 Diaz-Saez, L, Hunter, W.N. 登録日 2016-03-29 公開日 2016-10-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Open and compressed conformations of Francisella tularensis ClpP. Proteins, 85, 2017
5UI4	Structure of NME1 covalently conjugated to imidazole fluorosulfate 分子名称: 4-[4-(3-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-5-yl]phenyl sulfurofluoridate, Nucleoside diphosphate kinase A 著者 Mortenson, D.E, Brighty, G.J, Wilson, I.A, Kelly, J.W. 登録日 2017-01-12 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. J. Am. Chem. Soc., 140, 2018
5H94	Crystal structure of Swine MHC CLASSI for 1.48 angstroms 分子名称: Beta-2-microglobulin, MHC class I antigen, Nonapeptide from Influenza A virus HA protein 著者 Fan, S, Zhang, N, Wang, S, Wu, Y, Xia, C. 登録日 2015-12-25 公開日 2016-05-18 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains J.Virol., 90, 2016
5FU0	Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE, ... 著者 Alphey, M.S, Tran, F, Westwood, N.J, Naismith, J.H. 登録日 2016-01-19 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Allosteric Competitive Inhibitors of the Glucose-1-Phosphate Thymidylyltransferase (Rmla) from Pseudomonas Aeruginosa. To be Published
4N9L	crystal structure of beta-lactamse PenP_E166S in complex with meropenem 分子名称: (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase 著者 Pan, X, Wong, W, Zhao, Y. 登録日 2013-10-21 公開日 2014-09-10 最終更新日 2022-02-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 53, 2014

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