4Y3C
 
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5IJL
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4Y2A
 | | Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor | | 分子名称: | 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | | 著者 | Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N. | | 登録日 | 2015-02-09 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
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4Y34
 | | Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143 | | 分子名称: | 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | | 著者 | Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N. | | 登録日 | 2015-02-10 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
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5IHE
 | | D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) | | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ACETATE ION, ... | | 著者 | Sauguet, L, Raia, P, De Larue, M. | | 登録日 | 2016-02-29 | | 公開日 | 2016-08-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.
Nat Commun, 7, 2016
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5H0R
 | | RNA dependent RNA polymerase ,vp4,dsRNA | | 分子名称: | RNA (42-MER), RNA-dependent RNA polymerase, VP4 protein | | 著者 | Li, X, Zhou, N, Chen, W, Zhu, B, Wang, X, Xu, B, Wang, J, Liu, H, Cheng, L. | | 登録日 | 2016-10-06 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV
J. Mol. Biol., 429, 2017
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4ROD
 | | Human TFIIB-related factor 2 (Brf2) and TBP bound to TRNAU1 promoter | | 分子名称: | Non-template strand, TATA-box-binding protein, Template strand, ... | | 著者 | Vannini, A, Gouge, J, Satia, K, Guthertz, N. | | 登録日 | 2014-10-28 | | 公開日 | 2015-12-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2.
Cell(Cambridge,Mass.), 163, 2015
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5TSN
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3H5X
 | | Crystal Structure of 2'-amino-2'-deoxy-cytidine-5'-triphosphate bound to Norovirus GII RNA polymerase | | 分子名称: | 2'-amino-2'-deoxycytidine 5'-(tetrahydrogen triphosphate), 5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3', 5'-R(P*UP*GP*CP*CP*CP*GP*GP*GP*C)-3', ... | | 著者 | Zamyatkin, D.F, Parra, F, Machin, A, Grochulski, P, Ng, K.K.S. | | 登録日 | 2009-04-22 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site.
J.Mol.Biol., 390, 2009
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3OL8
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5N9G
 | | TFIIIB -TBP/Brf2/DNA and SANT domain of Bdp1- | | 分子名称: | DNA/RNA (25-MER), DNA/RNA (27-MER), SODIUM ION, ... | | 著者 | Gouge, J, Vannini, A, Guthertz, N. | | 登録日 | 2017-02-24 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.
Nat Commun, 8, 2017
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7Y7S
 | | QDE-1 in complex with DNA template, RNA primer and AMPNPP | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Cui, R.X, Gan, J.H, Ma, J.B. | | 登録日 | 2022-06-22 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
Nucleic Acids Res., 50, 2022
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3N6N
 | | crystal structure of EV71 RdRp in complex with Br-UTP | | 分子名称: | 5-bromouridine 5'-(tetrahydrogen triphosphate), NICKEL (II) ION, RNA-dependent RNA polymerase | | 著者 | Wu, Y, Lou, Z.Y, Miao, Y, Yu, Y, Rao, Z.H. | | 登録日 | 2010-05-26 | | 公開日 | 2011-06-15 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
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3N6M
 | | Crystal structure of EV71 RdRp in complex with GTP | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, NICKEL (II) ION, RNA-dependent RNA polymerase | | 著者 | Wu, Y, Lou, Z.Y, Miao, Y, Yu, Y, Rao, Z.H. | | 登録日 | 2010-05-26 | | 公開日 | 2011-06-15 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
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4BJJ
 | | Sfc1-Sfc7 dimerization module | | 分子名称: | MERCURY (II) ION, TRANSCRIPTION FACTOR TAU SUBUNIT SFC1, TRANSCRIPTION FACTOR TAU SUBUNIT SFC7 | | 著者 | Taylor, N.M.I, Baudin, F, von Scheven, G, Muller, C.W. | | 登録日 | 2013-04-18 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | RNA Polymerase III-Specific General Transcription Factor Iiic Contains a Heterodimer Resembling Tfiif RAP30/RAP74.
Nucleic Acids Res., 41, 2013
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2F88
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2A0C
 | | Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor | | 分子名称: | 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL, Cell division protein kinase 2 | | 著者 | Krystof, V, McNae, I.W, Walkinshaw, M.D, Fischer, P.M, Muller, P, Vojtesek, B, Orsag, M, Havlicek, L, Strnad, M. | | 登録日 | 2005-06-16 | | 公開日 | 2006-01-24 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor
Cell.Mol.Life Sci., 62, 2005
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7ZPM
 | | Influenza A/H7N9 polymerase apo-protein dimer complex | | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit | | 著者 | Cusack, S, Kouba, T. | | 登録日 | 2022-04-27 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | | 主引用文献 | Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
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8FFZ
 | | TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene | | 分子名称: | DNA (151-MER), Transcription factor IIIA, Transcription factor IIIB 70 kDa subunit,TATA-box-binding protein, ... | | 著者 | Talyzina, A, He, Y. | | 登録日 | 2022-12-11 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation.
Mol.Cell, 83, 2023
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2E9T
 | | Foot-and-mouth disease virus RNA-polymerase RNA dependent in complex with a template-primer RNA and 5F-UTP | | 分子名称: | 5'-R(*GP*GP*GP*CP*CP*CP*(5FU))-3', 5'-R(P*UP*AP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... | | 著者 | Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. | | 登録日 | 2007-01-26 | | 公開日 | 2007-06-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Sequential structures provide insights into the fidelity of RNA replication
Proc.Natl.Acad.Sci.Usa, 104, 2007
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6QI9
 | | Truncated human R2TP complex, structure 4 (ADP-empty) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | | 登録日 | 2019-01-18 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.63 Å) | | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM.
Sci Adv, 5, 2019
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6QI8
 | | Truncated human R2TP complex, structure 3 (ADP-filled) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | | 登録日 | 2019-01-18 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM.
Sci Adv, 5, 2019
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8H69
 | | Cryo-EM structure of influenza RNA polymerase | | 分子名称: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ... | | 著者 | Li, H, Wu, Y, Liang, H, Liu, Y. | | 登録日 | 2022-10-16 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles.
Nat.Struct.Mol.Biol., 30, 2023
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7ZGR
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7ZGP
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