4HBX
 
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand | | 分子名称: | 3-methyl-6-(pyrrolidin-1-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4 | | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2012-09-28 | | 公開日 | 2012-10-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.
J.Med.Chem., 55, 2012
|
|
4PE4
 | | Crystal Structure of Calcium-loaded S100B bound to SC1475 | | 分子名称: | 2,3-dimethoxy-5-[(1S)-1-phenylpropyl]benzene-1,4-diol, CALCIUM ION, Protein S100-B | | 著者 | Cavalier, M.C, Pierce, A.D, Wilder, P.T, Neau, D, Toth, E.A, Weber, D.J. | | 登録日 | 2014-04-22 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.178 Å) | | 主引用文献 | Covalent Small Molecule Inhibitors of Ca(2+)-Bound S100B.
Biochemistry, 53, 2014
|
|
1W0N
 | | Structure of uncomplexed Carbohydrate Binding Domain CBM36 | | 分子名称: | CALCIUM ION, ENDO-1,4-BETA-XYLANASE D, MAGNESIUM ION, ... | | 著者 | Jamal, S, Boraston, A.B, Davies, G.J. | | 登録日 | 2004-06-09 | | 公開日 | 2004-10-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (0.8 Å) | | 主引用文献 | Ab Initio Structure Determination and Functional Characterization of Cbm36: A New Family of Calcium-Dependent Carbohydrate Binding Modules
Structure, 12, 2004
|
|
7DB2
 | | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in GS-dimedone-bound form | | 分子名称: | 5,5-DIMETHYLCYCLOHEXANE-1,3-DIONE, DIMETHYL SULFOXIDE, GLUTATHIONE, ... | | 著者 | Koiwai, K, Inaba, K, Yumoto, F, Senda, T, Niwa, R. | | 登録日 | 2020-10-18 | | 公開日 | 2021-02-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S -transferase Noppera-bo
J Pestic Sci, 46, 2021
|
|
172L
 | |
1LRU
 | | Crystal Structure of E.coli Peptide Deformylase Complexed with Antibiotic Actinonin | | 分子名称: | ACTINONIN, PEPTIDE DEFORMYLASE, SULFATE ION, ... | | 著者 | Guilloteau, J.-P, Mathieu, M, Giglione, C, Blanc, V, Dupuy, A, Chevrier, M, Gil, P, Famechon, A, Meinnel, T, Mikol, V. | | 登録日 | 2002-05-16 | | 公開日 | 2002-07-24 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
J.Mol.Biol., 320, 2002
|
|
8IP1
 | | Escherichia coli OpgD mutant-D388N with beta-1,2-glucan | | 分子名称: | DI(HYDROXYETHYL)ETHER, Glucans biosynthesis protein D, TRIETHYLENE GLYCOL, ... | | 著者 | Motouchi, S, Nakajima, M. | | 登録日 | 2023-03-13 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Identification of enzymatic functions of osmo-regulated periplasmic glucan biosynthesis proteins from Escherichia coli reveals a novel glycoside hydrolase family.
Commun Biol, 6, 2023
|
|
1VPT
 | | AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE | | 分子名称: | S-ADENOSYLMETHIONINE, VP39 | | 著者 | Hodel, A.E, Gershon, P.D, Shi, X, Quiocho, F.A. | | 登録日 | 1996-03-20 | | 公開日 | 1996-08-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends.
Cell(Cambridge,Mass.), 85, 1996
|
|
5TBM
 | | Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex | | 分子名称: | 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | | 著者 | Du, X. | | 登録日 | 2016-09-12 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A Small-Molecule Antagonist of HIF2 alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Cancer Res., 76, 2016
|
|
3PXH
 | | Tandem Ig domains of tyrosine phosphatase LAR | | 分子名称: | Receptor-type tyrosine-protein phosphatase F, SULFATE ION | | 著者 | Biersmith, B.H, Bouyain, S. | | 登録日 | 2010-12-09 | | 公開日 | 2011-03-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.0009 Å) | | 主引用文献 | The Immunoglobulin-like Domains 1 and 2 of the Protein Tyrosine Phosphatase LAR Adopt an Unusual Horseshoe-like Conformation.
J.Mol.Biol., 408, 2011
|
|
7DB1
 | | Crystal structure of Drosophila melanogaster Noppera-bo, glutathione S-transferase epsilon 14 (DmGSTE14), in dimedone- and glutathione-bound form | | 分子名称: | 5,5-DIMETHYLCYCLOHEXANE-1,3-DIONE, DIMETHYL SULFOXIDE, GLUTATHIONE, ... | | 著者 | Koiwai, K, Inaba, K, Yumoto, F, Senda, T, Niwa, R. | | 登録日 | 2020-10-18 | | 公開日 | 2021-02-10 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S -transferase Noppera-bo
J Pestic Sci, 46, 2021
|
|
4ZCJ
 | |
4ACG
 | | GSK3b in complex with inhibitor | | 分子名称: | 2-AMINO-5-{4-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-N-[4-(PYRROLIDIN-1-YLMETHYL)PYRIDIN-3-YL]PYRIDINE-3-CARBOXAMIDE, GLYCOGEN SYNTHASE KINASE-3 BETA | | 著者 | Xue, Y, Ormo, M. | | 登録日 | 2011-12-15 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of novel potent and highly selective glycogen synthase kinase-3 beta (GSK3 beta ) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
J. Med. Chem., 55, 2012
|
|
7D5C
 | | IleRS in complex with a tRNA site inhibitor | | 分子名称: | (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl)oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic acid, 1,2-ETHANEDIOL, Isoleucine--tRNA ligase, ... | | 著者 | Chen, B, Luo, S, Zhou, H. | | 登録日 | 2020-09-25 | | 公開日 | 2021-02-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.895 Å) | | 主引用文献 | Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase.
Nat Commun, 12, 2021
|
|
1IRW
 | |
1LQF
 | | Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor | | 分子名称: | N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE, protein-tyrosine phosphatase, non-receptor type 1 | | 著者 | Asante-Appiah, E, Patel, S, Dufresne, C, Scapin, G. | | 登録日 | 2002-05-10 | | 公開日 | 2002-07-24 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Biochemistry, 41, 2002
|
|
5TRK
 | |
3GVB
 | |
1VEZ
 | | Crystal Structure of Peptide Deformylase from Leptospira Interrogans(LiPDF) at pH8.0 | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FORMIC ACID, Peptide deformylase, ... | | 著者 | Zhou, Z, Song, X, Li, Y, Gong, W. | | 登録日 | 2004-04-06 | | 公開日 | 2005-08-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Novel conformational states of peptide deformylase from pathogenic bacterium Leptospira interrogans: implications for population shift
J.Biol.Chem., 280, 2005
|
|
3PMY
 | | Endothiapepsin in complex with a fragment | | 分子名称: | Endothiapepsin, GLYCEROL, N-(1H-benzimidazol-1-yl)-2-phenylacetamide | | 著者 | Koester, H, Heine, A, Klebe, G. | | 登録日 | 2010-11-18 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes.
J.Med.Chem., 54, 2011
|
|
5CZ8
 | |
5D0Z
 | |
4NDA
 | | Crystal structure of 3-nitro-tyrosine tRNA synthetase (5B) bound to 3-nitro-tyrosine | | 分子名称: | GLYCEROL, META-NITRO-TYROSINE, SODIUM ION, ... | | 著者 | Cooley, R.B, Driggers, C.M, Karplus, P.A, Mehl, R.A. | | 登録日 | 2013-10-25 | | 公開日 | 2014-03-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural Basis of Improved Second-Generation 3-Nitro-tyrosine tRNA Synthetases.
Biochemistry, 53, 2014
|
|
6KL5
 | | Structure of The N-terminal domain of Middle East respiratory syndrome coronavirus Nucleocapsid Protein complexed with Benzyl 2-(Hydroxymethyl)-1-Indolinecarboxylate | | 分子名称: | (phenylmethyl) (2S)-2-(hydroxymethyl)-2,3-dihydroindole-1-carboxylate, Nucleoprotein | | 著者 | Hou, M.H, Lin, S.M, Hsu, J.N, Wang, Y.S. | | 登録日 | 2019-07-29 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design.
J.Med.Chem., 63, 2020
|
|
254L
 | | LYSOZYME | | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME | | 著者 | Kuroki, R, Shoichet, B, Weaver, L.H, Matthews, B.W. | | 登録日 | 1997-11-10 | | 公開日 | 1998-01-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A relationship between protein stability and protein function.
Proc.Natl.Acad.Sci.USA, 92, 1995
|
|
