Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5CZ8

Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib

Summary for 5CZ8
Entry DOI10.2210/pdb5cz8/pdb
Related5CZ4
Related PRD IDPRD_001243
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, proteasome, mutant, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
More
Total number of polymer chains28
Total formula weight736495.43
Authors
Huber, E.M.,Groll, M. (deposition date: 2015-07-31, release date: 2016-03-23, Last modification date: 2024-01-10)
Primary citationHuber, E.M.,Heinemeyer, W.,Li, X.,Arendt, C.S.,Hochstrasser, M.,Groll, M.
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun, 7:10900-10900, 2016
Cited by
PubMed: 26964885
DOI: 10.1038/ncomms10900
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon