5CZ8

Yeast 20S proteasome beta5-L(-49)S-K33A mutant in complex with Carfilzomib

Summary for 5CZ8

Related5CZ4
Related PRD IDPRD_001243
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (19 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, proteasome, mutant, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
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Total number of polymer chains28
Total molecular weight736495.43
Authors
Huber, E.M.,Groll, M. (deposition date: 2015-07-31, release date: 2016-03-23, Last modification date: 2018-10-31)
Primary citation
Huber, E.M.,Heinemeyer, W.,Li, X.,Arendt, C.S.,Hochstrasser, M.,Groll, M.
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun, 7:10900-10900, 2016
PubMed: 26964885 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms10900
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2191 0.2% 2.7% 1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution