1KTW
 
 | | IOTA-CARRAGEENASE COMPLEXED TO IOTA-CARRAGEENAN FRAGMENTS | | 分子名称: | 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranose-(1-3)-4-O-sulfo-beta-D-galactopyranose, 3,6-anhydro-2-O-sulfo-alpha-D-galactopyranose-(1-3)-4-O-sulfo-beta-D-galactopyranose-(1-4)-3,6-anhydro-2-O-sulfo-alpha-D-galactopyranose-(1-3)-4-O-sulfo-beta-D-galactopyranose, CALCIUM ION, ... | | 著者 | Michel, G, Kahn, R, Dideberg, O. | | 登録日 | 2002-01-18 | | 公開日 | 2003-06-10 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Structural Bases of the Processive Degradation of iota-Carrageenan, a Main Cell Wall Polysaccharide of Red Algae.
J.Mol.Biol., 334, 2003
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464D
 | | DISORDER AND TWIN REFINEMENT OF RNA HEPTAMER DOUBLE HELIX | | 分子名称: | RNA (5'-R(*GP*GP*GP*GP*CP*(IU)P*A)-3'), RNA (5'-R(*UP*AP*GP*CP*UP*CP*C)-3'), SODIUM ION, ... | | 著者 | Mueller, U, Muller, Y.A, Herbst-Irmer, R, Sprinzl, M, Heinemann, U. | | 登録日 | 1999-04-14 | | 公開日 | 1999-08-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Disorder and twin refinement of RNA heptamer double helices.
Acta Crystallogr.,Sect.D, 55, 1999
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5TFM
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4AJX
 | | Ligand controlled assembly of hexamers, dihexamers, and linear multihexamer structures by an engineered acylated insulin | | 分子名称: | IMIDAZOLE, INSULIN, N-(16-Carboxyhexadecanoyl)-L-glutamic acid, ... | | 著者 | Steensgaard, D.B, Schluckebier, G, Strauss, H.M, Norrman, M, Thomsen, J.K, Friderichsen, A.V, Havelund, S, Jonassen, I. | | 登録日 | 2012-02-20 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Ligand Controlled Assembly of Hexamers, Dihexamers, and Linear Multihexamer Structures by the Engineered Acylated Insulin Degludec.
Biochemistry, 52, 2013
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6Y8X
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4AFX
 | | Crystal structure of the reactive loop cleaved ZPI in I2 space group | | 分子名称: | CALCIUM ION, PHOSPHATE ION, PROTEIN Z DEPENDENT PROTEASE INHIBITOR, ... | | 著者 | Zhou, A, Yan, Y, Wei, Z. | | 登録日 | 2012-01-23 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural Basis for Catalytic Activation of Protein Z-Dependent Protease Inhibitor (Zpi) by Protein Z.
Blood, 120, 2012
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5V9G
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5USP
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3WE7
 | | Crystal Structure of Diacetylchitobiose Deacetylase from Pyrococcus horikoshii | | 分子名称: | ACETIC ACID, GLYCEROL, HEXANE-1,6-DIOL, ... | | 著者 | Mine, S, Nakamura, T, Fukuda, Y, Inoue, T, Uegaki, K, Sato, T. | | 登録日 | 2013-07-01 | | 公開日 | 2014-05-07 | | 最終更新日 | 2014-08-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Expression from engineered Escherichia coli chromosome and crystallographic study of archaeal N,N'-diacetylchitobiose deacetylase
Febs J., 281, 2014
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6Z57
 | | Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078 | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 10-(2-morpholin-4-ylethyl)-7-oxa-10,13,17,18,21-pentazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene, ... | | 著者 | Chaikuad, A, Benderitter, P, Hoflack, J, Denis, A, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-05-26 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of haspin (GSG2) in complex with macrocycle ODS2004078
To Be Published
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5XSY
 | | Structure of the Nav1.4-beta1 complex from electric eel | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | | 著者 | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | | 登録日 | 2017-06-15 | | 公開日 | 2017-08-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structure of the Nav1.4-beta 1 Complex from Electric Eel.
Cell, 170, 2017
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6WY4
 | | Crystal Structure of Wild Type Class D beta-lactamase from Clostridium difficile 630 | | 分子名称: | Beta-lactamase, DI(HYDROXYETHYL)ETHER, SODIUM ION | | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Rosas-Lemus, M, Jedrzejczak, R, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-05-12 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of Wild Type Class D beta-lactamase from Clostridium difficile 630
To Be Published
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7OJM
 | | CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-H-3-HYDROXY-4- OXOQUINALDINE 2,4-DIOXYGENASE (HOD) CATALYTICALLY INACTIVE H251A VARIANT COMPLEXED WITH 2-METHYL-QUINOLIN-4(1H)-ONE UNDER NORMOXIC CONDITIONS | | 分子名称: | 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase, 2-methyl-quinolin-4(1H)-one, GLYCEROL, ... | | 著者 | Bui, S, Steiner, R.A. | | 登録日 | 2021-05-16 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | | 主引用文献 | Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the alpha / beta-hydrolase fold.
Chem Sci, 14, 2023
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3WV2
 | | Crystal structure of the catalytic domain of MMP-13 complexed with N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide | | 分子名称: | CALCIUM ION, Collagenase 3, N-(3-methoxybenzyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide, ... | | 著者 | Oki, H, Tanaka, Y. | | 登録日 | 2014-05-12 | | 公開日 | 2014-09-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1′′ binding site.
Bioorg.Med.Chem., 22, 2014
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5X5G
 | | Crystal structure of TLA-3 extended-spectrum beta-lactamase in a complex with OP0595 | | 分子名称: | (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, SODIUM ION, ... | | 著者 | Wachino, J, Jin, W, Arakawa, Y. | | 登録日 | 2017-02-15 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insights into the TLA-3 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam and OP0595.
Antimicrob. Agents Chemother., 61, 2017
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5V04
 | | Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' recessed-end DNA (rII) | | 分子名称: | DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), Exonuclease 1, ... | | 著者 | Shi, Y, Beese, L.S. | | 登録日 | 2017-02-28 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5V0A
 | | Crystal structure of human exonuclease 1 Exo1 (D225A) in complex with 5' recessed-end DNA (rVIII) | | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(P*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ... | | 著者 | Shi, Y, Beese, L.S. | | 登録日 | 2017-02-28 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5X6V
 | | Crystal structure of human heteroheptameric complex | | 分子名称: | ACETATE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | | 著者 | Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. | | 登録日 | 2017-02-23 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
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5ULT
 | | HIV-1 wild Type protease with GRL-100-13A (a Crown-like Oxotricyclic Core as the P2-Ligand with the sulfonamide isostere as the P2' group) | | 分子名称: | (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, CHLORIDE ION, Protease, ... | | 著者 | Wang, Y.-F, Agniswamy, J, Weber, I.T. | | 登録日 | 2017-01-25 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.
J. Med. Chem., 60, 2017
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7SLA
 | | CryoEM structure of SGLT1 at 3.15 Angstrom resolution | | 分子名称: | CHOLESTEROL HEMISUCCINATE, Sodium/glucose cotransporter 1, nanobody Nb1 | | 著者 | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | 登録日 | 2021-10-23 | | 公開日 | 2021-12-15 | | 最終更新日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7SL8
 | | CryoEM structure of SGLT1 at 3.4 A resolution | | 分子名称: | CHOLESTEROL, Sodium/glucose cotransporter 1, nanobody Nb1 | | 著者 | Qu, Q, Han, L, Panova, O, Feng, L, Skiniotis, G. | | 登録日 | 2021-10-23 | | 公開日 | 2021-12-15 | | 最終更新日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure and mechanism of the SGLT family of glucose transporters.
Nature, 601, 2022
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7JYW
 | | Crystal Structure of HLA A*2402 in complex with TYQWIIRNW, an 9-mer influenza epitope | | 分子名称: | Beta-2-microglobulin, CALCIUM ION, MHC class I antigen, ... | | 著者 | Gras, S, Nguyen, A.T, Szeto, C, Rossjohn, J. | | 登録日 | 2020-09-01 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | CD8 + T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph.
Nat Commun, 12, 2021
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6Z6A
 | | Keap1 macrocycle complex | | 分子名称: | (5S,8R)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-N,N-dimethyl-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-5-carboxamide, CHLORIDE ION, Kelch-like ECH-associated protein 1, ... | | 著者 | Johansson, P. | | 登録日 | 2020-05-28 | | 公開日 | 2020-12-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | | 主引用文献 | Mining Natural Products for Macrocycles to Drug Difficult Targets.
J.Med.Chem., 64, 2021
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435D
 | | 5'-R(*UP*AP*GP*CP*CP*CP*C)-3', 5'-R(*GP*GP*GP*GP*CP*UP*A)-3' | | 分子名称: | RNA (5'-R(*GP*GP*GP*GP*CP*UP*A)-3'), RNA (5'-R(*UP*AP*GP*CP*CP*CP*C)-3'), SODIUM ION | | 著者 | Mueller, U, Schuebel, H, Sprinzl, M, Heinemann, U. | | 登録日 | 1998-10-23 | | 公開日 | 1999-06-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal structure of acceptor stem of tRNA(Ala) from Escherichia coli shows unique G.U wobble base pair at 1.16 A resolution.
RNA, 5, 1999
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7JXX
 | | Structure of TTBK1 kinase domain in complex with Compound 3 | | 分子名称: | 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol, SODIUM ION, Tau-tubulin kinase 1 | | 著者 | Chodaprambil, J.V. | | 登録日 | 2020-08-28 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
J.Med.Chem., 64, 2021
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