PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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1E8L	NMR solution structure of hen lysozyme 分子名称: LYSOZYME 著者 Schwalbe, H, Grimshaw, S.B, Spencer, A, Buck, M, Boyd, J, Dobson, C.M, Redfield, C, Smith, L.J. 登録日 2000-09-27 公開日 2000-10-09 最終更新日 2018-01-24 実験手法 SOLUTION NMR 主引用文献 A refined solution structure of hen lysozyme determined using residual dipolar coupling data. Protein Sci., 10, 2001
2ITX	Crystal structure of EGFR kinase domain in complex with AMP-PNP 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J. 登録日 2006-05-25 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007
2J1Z	Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Fersht, A.R. 登録日 2006-08-15 公開日 2006-09-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006
2IWR	Gtpase Like Domain Of Centaurin Gamma 1 (Human) 分子名称: CENTAURIN GAMMA 1 著者 Elkins, J.M, Soundararajan, M, Yang, X, Papagrigoriou, E, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2006-07-03 公開日 2006-07-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Centaurin Gamma-1 Gtpase-Like Domain Functions as an Ntpase. Biochem.J., 401, 2007
2R6N	Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K 分子名称: 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine, Cathepsin K 著者 Cowan-Jacob, S.W, Ramage, P, Mathis, B, Geisse, S. 登録日 2007-09-06 公開日 2007-11-06 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Novel scaffold for cathepsin K inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
2Z7R	Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine 分子名称: Ribosomal protein S6 kinase alpha-1, STAUROSPORINE 著者 Ikuta, M, Munshi, S.K. 登録日 2007-08-28 公開日 2008-05-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Protein Sci., 16, 2007
2Z6K	Crystal structure of full-length human RPA14/32 heterodimer 分子名称: Replication protein A 14 kDa subunit, Replication protein A 32 kDa subunit 著者 Deng, X, Habel, J.E, Kabaleeswaran, V, Borgstahl, G.E. 登録日 2007-08-03 公開日 2007-12-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the Full-length Human RPA14/32 Complex Gives Insights into the Mechanism of DNA Binding and Complex Formation J.Mol.Biol., 374, 2007
2RA3	Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI) 分子名称: CALCIUM ION, Pancreatic trypsin inhibitor, SULFATE ION, ... 著者 Salameh, M.A, Soares, A.S, Radisky, E.S. 登録日 2007-09-14 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin. J.Biol.Chem., 283, 2008
2R9Y	Structure of antiplasmin 分子名称: Alpha-2-antiplasmin 著者 Law, R.H.P, Sofian, T, Kan, W.T, Horvath, A.J, Hitchen, C.R, Langendorf, C.G, Buckle, A.M, Whisstock, J.C, Coughlin, P.B. 登録日 2007-09-14 公開日 2007-12-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin Blood, 111, 2008
3IN8	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic 分子名称: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide 著者 Benfield, A.P, Clements, J.H. 登録日 2009-08-11 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
2ITP	Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788 分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR 著者 Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J. 登録日 2006-05-25 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007
2ITW	Crystal structure of EGFR kinase domain in complex with AFN941 分子名称: 1,2,3,4-Tetrahydrogen Staurosporine, EPIDERMAL GROWTH FACTOR RECEPTOR 著者 Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J. 登録日 2006-05-25 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007
2ITT	Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788 分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR 著者 Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J. 登録日 2006-05-25 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007
2J0D	Crystal structure of human P450 3A4 in complex with erythromycin 分子名称: CYTOCHROME P450 3A4, ERYTHROMYCIN A, PROTOPORPHYRIN IX CONTAINING FE 著者 Sjogren, T, Ekroos, M. 登録日 2006-08-02 公開日 2006-09-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4 Proc.Natl.Acad.Sci.USA, 103, 2006
2ITN	Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J. 登録日 2006-05-25 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11, 2007
2Z5S	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
2J21	Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Fersht, A.R. 登録日 2006-08-15 公開日 2006-09-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Y	Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D 分子名称: CALCIUM ION, CELLULAR TUMOR ANTIGEN P53, ZINC ION 著者 Joerger, A.C, Fersht, A.R. 登録日 2006-08-15 公開日 2006-09-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006
2RNA	Itk SH3 average minimized 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Severin, A.J. 登録日 2007-12-08 公開日 2007-12-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR structure note: murine Itk SH3 domain To be Published
3ITI	Structure of bovine trypsin with the MAD triangle B3C 分子名称: 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid, BENZAMIDINE, CALCIUM ION, ... 著者 Beck, T, da Cunha, C.E, Sheldrick, G.M. 登録日 2009-08-28 公開日 2009-10-27 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 How to get the magic triangle and the MAD triangle into your protein crystal. Acta Crystallogr.,Sect.F, 65, 2009
2ZDK	Exploring Trypsin S3 Pocket 分子名称: (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ... 著者 Baum, B, Brandt, T, Heine, A, Klebe, G. 登録日 2007-11-26 公開日 2008-10-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Congeneric but still distinct: how closely related trypsin ligands exhibit different thermodynamic and structural properties J.Mol.Biol., 405, 2011
2ZDV	Exploring Thrombin S1 pocket 分子名称: D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide, Hirudin variant-1, PHOSPHATE ION, ... 著者 Baum, B, Heine, A, Klebe, G. 登録日 2007-11-29 公開日 2008-10-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Exploring Thrombin S1 pocket To be Published
3IMA	Complex structure of tarocystatin and papain 分子名称: ACETATE ION, Cysteine proteinase inhibitor, Papain 著者 Chu, M.H, Liu, K.L, Yeh, K.W, Cheng, Y.S. 登録日 2009-08-10 公開日 2010-02-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystal structure of tarocystatin-papain complex: implications for the inhibition property of group-2 phytocystatins. Planta, 234, 2011
2ZGJ	Crystal Structure of D86N-GzmM Complexed with Its Optimal Synthesized Substrate 分子名称: Granzyme M, SSGKVPLS, SULFATE ION 著者 Wu, L.F, Wang, L, Hua, G.Q, Liu, K, Zhai, Y.J, Sun, F, Fan, Z.S. 登録日 2008-01-22 公開日 2009-01-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M J.Immunol., 183, 2009
2R9B	Structural Analysis of Plasmepsin 2 from Plasmodium falciparum complexed with a peptide-based inhibitor 分子名称: Plasmepsin-2, peptide-based inhibitor 著者 Liu, P, Marzahn, M.R, Robbins, A.H, McKenna, R, Dunn, B.M. 登録日 2007-09-12 公開日 2007-11-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis. Biochemistry, 48, 2009

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