PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

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7MYO	Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719 分子名称: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Liu, X, Yang, S, Hart, J.R, Xu, Y, Zou, X, Zhang, H, Zhou, Q, Xia, T, Zhang, Y, Yang, D, Wang, M.-W, Vogt, P.K. 登録日 2021-05-21 公開日 2021-11-10 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.92 Å) 主引用文献 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation. Proc.Natl.Acad.Sci.USA, 118, 2021
6WJQ	Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 分子名称: 3-phosphoinositide-dependent protein kinase 1, WD repeat-containing protein 5 著者 Zhao, B, Fesik, S. 登録日 2020-04-14 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 Cell Rep, 2021
8B8T	Open conformation of the complex of DNA ligase I on PCNA and DNA in the presence of ATP 分子名称: DNA ligase 1, Proliferating cell nuclear antigen 著者 Blair, K, Tehseen, M, Raducanu, V.S, Shahid, T, Lancey, C, Cruehet, R, Hamdan, S, De Biasio, A. 登録日 2022-10-05 公開日 2023-01-11 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Mechanism of human Lig1 regulation by PCNA in Okazaki fragment sealing. Nat Commun, 13, 2022
6ISE	Crystal structure of AMPPNP bound CK2 alpha from C. neoformans 分子名称: 1,2-ETHANEDIOL, Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Cho, H.S. 登録日 2018-11-16 公開日 2019-11-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of AMPPNP bound CK2 alpha from C. neoformans To be published
5UOJ	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION 分子名称: Mitogen-activated protein kinase 14 著者 CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J. 登録日 2017-01-31 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A., 94, 1997
8PP6	human RYBP-PRC1 bound to H2AK118ub1 nucleosome 分子名称: DNA (215-MER), Histone H2A, Histone H2B, ... 著者 Ciapponi, M, Benda, C, Mueller, J. 登録日 2023-07-06 公開日 2024-04-03 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1. Nat.Struct.Mol.Biol., 31, 2024
2JNJ	Solution structure of the p8 TFIIH subunit 分子名称: TFIIH basal transcription factor complex TTD-A subunit 著者 Vitorino, M, Atkinson, R.A, Moras, D, Poterszman, A, Kieffer, B, Structural Proteomics in Europe 2 (SPINE-2) 登録日 2007-01-26 公開日 2007-04-10 最終更新日 2023-12-20 実験手法 SOLUTION NMR 主引用文献 Solution Structure and Self-association Properties of the p8 TFIIH Subunit Responsible for Trichothiodystrophy J.Mol.Biol., 368, 2007
7SC0	CryoEM structure of the Caveolin-1 8S complex 分子名称: Caveolin-1 著者 Porta, J.P, Ohi, M.D, Kenworthy, A.K, Karakas, E. 登録日 2021-09-26 公開日 2022-05-25 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular architecture of the human caveolin-1 complex. Sci Adv, 8, 2022
2Z7L	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid 分子名称: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Katayama, N, Kurihara, H. 登録日 2007-08-27 公開日 2008-08-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors Proteins, 73, 2008
8UI7	Cryo-EM map of human clmap-clamp loader ATAD5-RFC-gapped PCNA complex in intermediate state 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI9	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-cracked PCNA complex in intermediate state 2 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UII	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-closed PCNA complex in intermediate state 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
8UI8	Cryo-EM map of human clamp-clamp loader ATAD5-RFC-two PCNAs complex in intermediate state 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATPase family AAA domain-containing protein 5, MAGNESIUM ION, ... 著者 Wang, F, He, Q, Li, H. 登録日 2023-10-10 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader. Nat.Struct.Mol.Biol., 2024
6M94	Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex 分子名称: Catenin beta-1, DIMETHYL SULFOXIDE, F-box/WD repeat-containing protein 1A, ... 著者 Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. 登録日 2018-08-22 公開日 2019-04-03 最終更新日 2019-04-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
6GYU	Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore 分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-02 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
5VHR	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHN	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (7.3 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHJ	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (8.5 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHQ	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
4X1L	Structural basis for mutation-induced destabilization of Profilin 1 in ALS 分子名称: PHOSPHATE ION, Profilin-1 著者 Silvas, T.V, Shandilya, S.M.D, Schiffer, C.A. 登録日 2014-11-24 公開日 2015-06-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 Structural basis for mutation-induced destabilization of profilin 1 in ALS. Proc.Natl.Acad.Sci.USA, 112, 2015
2RG6	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J 分子名称: 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 著者 Sack, J.S. 登録日 2007-10-02 公開日 2008-01-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008
5VHO	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (8.3 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
1LM8	Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex 分子名称: ELONGIN B, ELONGIN C, Hypoxia-inducible factor 1 alpha, ... 著者 Min, J.-H, Yang, H, Ivan, M, Gertler, F, Kaelin JR, W.G, Pavletich, N.P. 登録日 2002-04-30 公開日 2002-06-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science, 296, 2002
5VHM	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (8.3 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017
5VHP	Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle 分子名称: 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome non-ATPase regulatory subunit 2, 26S proteasome regulatory subunit 10B, ... 著者 Lu, Y, Wu, J, Dong, Y, Chen, S, Sun, S, Ma, Y.B, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. 登録日 2017-04-13 公開日 2017-08-23 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol. Cell, 67, 2017

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