6EBK
| The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 2,Potassium voltage-gated channel subfamily B member 2 chimera, Voltage-gated potassium channel subunit beta-2 | 著者 | Matthies, D, Bae, C, Fox, T, Bartesaghi, A, Subramaniam, S, Swartz, K.J. | 登録日 | 2018-08-06 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs. Elife, 7, 2018
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8HMB
| Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with benidipine (BEN) | 分子名称: | (3R)-1-benzylpiperidin-3-yl methyl (2R,3R,4R,5R,6S)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-12-02 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HMA
| Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-12-02 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HLP
| Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-11-30 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8IO3
| Cryo-EM structure of human HCN3 channel with cilobradine | 分子名称: | 3-[[(3~{S})-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-3-yl]methyl]-7,8-dimethoxy-2,5-dihydro-1~{H}-3-benzazepin-4-one, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 | 著者 | Yu, B, Lu, Q.Y, Li, J, Zhang, J. | 登録日 | 2023-03-10 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM structure of human HCN3 channel with cilobradine To Be Published
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6EBL
| The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs, cytosolic domain | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Potassium voltage-gated channel subfamily A member 2,Potassium voltage-gated channel subfamily B member 2 chimera, Voltage-gated potassium channel subunit beta-2 | 著者 | Matthies, D, Bae, C, Fox, T, Bartesaghi, A, Subramaniam, S, Swartz, K.J. | 登録日 | 2018-08-06 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs. Elife, 7, 2018
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8IO5
| Herg1a-herg1b closed state 2 | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | 著者 | Zhang, M.F. | 登録日 | 2023-03-10 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of Herg1a-herg1b open state To Be Published
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8IOB
| Herg1a-herg1b closed state 1 | 分子名称: | Potassium voltage-gated channel subfamily H member 2 | 著者 | Zhang, M.F. | 登録日 | 2023-03-10 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of Herg1a-herg1b closed state 1 To Be Published
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6G1K
| Electron cryo-microscopy structure of the canonical TRPC4 ion channel | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily c member 4a | 著者 | Vinayagam, D, Mager, T, Apelbaum, A, Bothe, A, Merino, F, Hofnagel, O, Gatsogiannis, C, Raunser, S. | 登録日 | 2018-03-21 | 公開日 | 2018-05-02 | 最終更新日 | 2018-08-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Electron cryo-microscopy structure of the canonical TRPC4 ion channel. Elife, 7, 2018
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6GYN
| Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2018-06-30 | 公開日 | 2019-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel To Be Published
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6GYO
| Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel in complex with cAMP | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | 著者 | Shintre, C.A, Pike, A.C.W, Tessitore, A, Young, M, Bushell, S.R, Strain-Damerell, C, Mukhopadhyay, S, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2018-06-30 | 公開日 | 2019-05-01 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel To Be Published
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3J5Q
| Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy | 分子名称: | Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 | 著者 | Liao, M, Cao, E, Julius, D, Cheng, Y. | 登録日 | 2013-10-28 | 公開日 | 2013-12-04 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | TRPV1 structures in distinct conformations reveal activation mechanisms. Nature, 504, 2013
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3J8H
| Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | 著者 | Yan, Z, Bai, X, Yan, C, Wu, J, Scheres, S.H.W, Shi, Y, Yan, N. | 登録日 | 2014-10-26 | 公開日 | 2014-12-10 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517, 2015
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3JBR
| Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Voltage-dependent L-type calcium channel subunit alpha-1S, ... | 著者 | Wu, J.P, Yan, Z, Yan, N. | 登録日 | 2015-09-29 | 公開日 | 2015-12-30 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of the voltage-gated calcium channel Cav1.1 complex Science, 350, 2015
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3J5P
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3J9J
| Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy | 分子名称: | Transient receptor potential cation channel subfamily V member 1 | 著者 | Wang, R.Y.-R, Barad, B.A, Fraser, J.S, DiMaio, F. | 登録日 | 2015-02-02 | 公開日 | 2015-09-02 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.275 Å) | 主引用文献 | EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy. Nat.Methods, 12, 2015
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3J5R
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3J9P
| Structure of the TRPA1 ion channel determined by electron cryo-microscopy | 分子名称: | Maltose-binding periplasmic protein, Transient receptor potential cation channel subfamily A member 1 chimera | 著者 | Paulsen, C.E, Armache, J.-P, Gao, Y, Cheng, Y, Julius, D. | 登録日 | 2015-02-14 | 公開日 | 2015-04-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.24 Å) | 主引用文献 | Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature, 520, 2015
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7AA5
| Human TRPV4 structure in presence of 4a-PDD | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein | 著者 | Botte, M, Ulrich, A.K.G, Adaixo, R, Gnutt, D, Brockmann, A, Bucher, D, Chami, M, Bocquet, M, Ebbinghaus-Kintscher, U, Puetter, V, Becker, A, Egner, U, Stahlberg, H, Hennig, M, Holton, S.J. | 登録日 | 2020-09-03 | 公開日 | 2021-08-18 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation To Be Published
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7B16
| TRPC4 in complex with inhibitor GFB-9289 | 分子名称: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{H}-pyridazin-6-one, CALCIUM ION, ... | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-23 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7B0S
| TRPC4 in complex with inhibitor GFB-8438 | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{H}-pyridazin-6-one, CALCIUM ION, ... | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-21 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7B1G
| TRPC4 in complex with Calmodulin | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, CALCIUM ION, Calmodulin-1, ... | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-24 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7B0J
| TRPC4 in LMNG detergent | 分子名称: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CALCIUM ION, Transient receptor potential cation channel subfamily c member 4a | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-20 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7B05
| TRPC4 in complex with inhibitor GFB-8749 | 分子名称: | (2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate, 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{H}-pyridazin-6-one, CALCIUM ION, ... | 著者 | Vinayagam, D, Quentin, D, Sistel, O, Merino, F, Stabrin, M, Hofnagel, O, Ledeboer, M.W, Malojcic, G, Raunser, S. | 登録日 | 2020-11-18 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. Elife, 9, 2020
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7SIT
| Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, OXYGEN ATOM, POTASSIUM ION, ... | 著者 | Reddi, R, Matulef, K, Riederer, E.A, Whorton, M.R, Valiyaveetil, F.I. | 登録日 | 2021-10-14 | 公開日 | 2022-05-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Structural basis for C-type inactivation in a Shaker family voltage-gated K + channel. Sci Adv, 8, 2022
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