PDB: 2682 件ウェブページステータス検索Chemie searchBIRD

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2Z4Y	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-252 分子名称: (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION 著者 Chen, C.K.-M, Guo, R.T, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-06-26 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
1XOI	Human Liver Glycogen Phosphorylase A complexed with Chloroindoloyl glycine amide 分子名称: 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID{[CYCLOPENTYL-(2-HYDROXY-ETHYL)-CARBAMOYL]-METHYL}-AMIDE, Glycogen phosphorylase, liver form, ... 著者 Wright, S.W, Rath, V.L, Gibbs, E.M, Treadway, J.L. 登録日 2004-10-06 公開日 2005-04-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization. Bioorg.Med.Chem.Lett., 15, 2005
1L5S	Human liver glycogen phosphorylase complexed with uric acid, N-Acetyl-beta-D-glucopyranosylamine, and CP-403,700 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, Glycogen phosphorylase, liver form, ... 著者 Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L. 登録日 2002-03-07 公開日 2002-12-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem.Biol., 9, 2002
1T4Q	Interleukin 1 beta F101W 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Guerrero, L, Caspar, D.L. 登録日 2004-04-30 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
4CTN	Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DIMETHYL SULFOXIDE, GLYCOGEN PHOSPHORYLASE, ... 著者 Alexacou, K.M, Papakonstantinou, M, Leonidas, D.D, Zographos, S.E, Chrysina, E.D. 登録日 2014-03-15 公開日 2014-08-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Glucopyranosylidene-Spiro-Iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods. Bioorg.Med.Chem., 22, 2014
1TWE	INTERLEUKIN 1 BETA MUTANT F101Y 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Capsar, D.L. 登録日 2004-06-30 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
2QLM	Glycogen phosphorylase in complex with FN67 分子名称: Glycogen phosphorylase, muscle form, N-{[(4-methylphenyl)carbonyl]carbamoyl}-beta-D-glucopyranosylamine 著者 Oikonomakos, N.G, Chryina, E.D, Tiraidis, C, Kosmopoulou, M.N, Zographos, S.E, Leonidas, D.D. 登録日 2007-07-13 公開日 2008-07-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation To be Published
4F62	Crystal structure of a putative farnesyl-diphosphate synthase from Marinomonas sp. MED121 (Target EFI-501980) 分子名称: CHLORIDE ION, GLYCEROL, Geranyltranstransferase, ... 著者 Vetting, M.W, Toro, R, Bhosle, R, Al Obaidi, N.F, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Poulter, C.D, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2012-05-14 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
5QTJ	T. brucei FPPS in complex with CID 47256035 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, N-[(2-chloro-6-fluorophenyl)methyl]-N,2-dimethylpyrimidine-4-carboxamide, ... 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W. 登録日 2019-08-09 公開日 2020-10-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 T. brucei FPPS in complex with CID 47256035 To Be Published
4QS9	Arabidopsis Hexokinase 1 (AtHXK1) mutant S177A structure in glucose-bound form 分子名称: Hexokinase-1, beta-D-glucopyranose 著者 Feng, J, Zhao, S, Liu, L. 登録日 2014-07-03 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.103 Å) 主引用文献 Biochemical and structural study of Arabidopsis hexokinase 1 Acta Crystallogr.,Sect.D, 71, 2015
8BGE	Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation 分子名称: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ... 著者 Koziej, L, Glatt, S. 登録日 2022-10-27 公開日 2023-08-16 実験手法 ELECTRON MICROSCOPY (2.11 Å) 主引用文献 Modulation of translational decoding by m 6 A modification of mRNA. Nat Commun, 14, 2023
4N9U	The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates 分子名称: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, Farnesyl pyrophosphate synthase, ... 著者 Tsoumpra, M.K, Muniz, J.R.C, Barnett, B.L, Pilka, E, Kwaasi, A.A, Kavanagh, K.L, Evdokimov, A, Walter, R.L, Ebetino, F.H, Oppermann, U, Russell, R.G.G, Dunford, J.E. 登録日 2013-10-21 公開日 2014-10-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates TO BE PUBLISHED
3H1V	Human glucokinase in complex with a synthetic activator 分子名称: 1-({5-[4-(methylsulfonyl)phenoxy]-2-pyridin-2-yl-1H-benzimidazol-6-yl}methyl)pyrrolidine-2,5-dione, Glucokinase, SODIUM ION, ... 著者 Kamata, K, Takahashi, K. 登録日 2009-04-14 公開日 2009-10-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg.Med.Chem., 17, 2009
5QTI	T. brucei FPPS in complex with CID 62483448 分子名称: 3-(2-bromophenoxy)pyridazine, Farnesyl pyrophosphate synthase, GLYCEROL, ... 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W. 登録日 2019-08-09 公開日 2020-10-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.112 Å) 主引用文献 T. brucei FPPS in complex with CID 62483448 To Be Published
5QTA	T. brucei FPPS in complex with CID 2804072 分子名称: 1,3-dichloro-2-[(methylsulfonyl)methyl]benzene, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. 登録日 2019-08-07 公開日 2020-10-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.113 Å) 主引用文献 T. brucei FPPS in complex with CID 2804072 To Be Published
5HN9	Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1186 分子名称: 2-{[3-(decyloxy)benzyl]oxy}-5-nitrobenzoic acid, Farnesyl pyrophosphate synthase, putative 著者 Liu, Y.-L, Zhang, Y, OIdfield, E. 登録日 2016-01-18 公開日 2016-09-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry, 55, 2016
4X38	Gallus interleukin-1 beta mutant - E118A 分子名称: IL-1 beta 著者 Yin, H.S, Cheng, W.T. 登録日 2014-11-28 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Gallus interleukin-1 beta mutant - E118A To Be Published
2E93	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-629 分子名称: Geranylgeranyl pyrophosphate synthetase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID 著者 Guo, R.T, Cao, R, Ko, T.P, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. 登録日 2007-01-24 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
2Z52	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-23 分子名称: (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID), Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION 著者 Guo, R.T, Chen, C.K.-M, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-06-26 公開日 2008-07-01 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
2E8T	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium, FsPP and IPP 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ... 著者 Guo, R.T, Ko, T.P, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. 登録日 2007-01-23 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
3IDH	Human pancreatic glucokinase in complex with glucose 分子名称: Glucokinase, POTASSIUM ION, alpha-D-glucopyranose 著者 Petit, P, Gluais, L, Lagarde, A, Boutin, J.A, Ferry, G, Vuillard, L. 登録日 2009-07-21 公開日 2010-07-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 The active conformation of human glucokinase is not altered by allosteric activators Acta Crystallogr.,Sect.D, 67, 2011
8AZW	Cryo-EM structure of the plant 60S subunit 分子名称: 25S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Smirnova, J, Loerke, J, Kleinau, G, Schmidt, A, Buerger, J, Meyer, E.H, Mielke, T, Scheerer, P, Bock, R, Spahn, C.M.T, Zoschke, R. 登録日 2022-09-06 公開日 2023-06-07 最終更新日 2023-06-28 実験手法 ELECTRON MICROSCOPY (2.14 Å) 主引用文献 Structure of the actively translating plant 80S ribosome at 2.2 angstrom resolution. Nat.Plants, 9, 2023
3BCR	Glycogen Phosphorylase b in complex with AZT 分子名称: 3'-azido-3'-deoxythymidine, Glycogen phosphorylase, muscle form 著者 Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. 登録日 2007-11-13 公開日 2008-11-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
2E91	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium and BPH-91 分子名称: Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ZOLEDRONIC ACID 著者 Guo, R.T, Ko, T.P, Cao, R, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. 登録日 2007-01-24 公開日 2007-06-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
3G2J	Crystal structure of 1-(beta-D-glucopyranosyl)-4-substituted-1,2,3-triazoles in complex with glycogen phosphorylase 分子名称: Glycogen phosphorylase, muscle form, N-(hydroxyacetyl)-beta-D-glucopyranosylamine 著者 Chrysina, E.D, Bokor, E, Alexacou, K.-M, Charavgi, M.-D, Oikonomakos, G.N, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G, Somsak, L. 登録日 2009-01-31 公開日 2010-02-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case Tetrahedron: Asymmetry, 20, 2009

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