6MMR
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.13 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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5IPQ
| Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 2 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (13.5 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
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6MMB
| Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (12.7 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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5IKB
| Crystal structure of the kainate receptor GluK4 ligand binding domain in complex with kainate | 分子名称: | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLYCEROL, Glutamate receptor ionotropic, ... | 著者 | Kristensen, O, Kristensen, L.B, Frydenvang, K, Kastrup, J.S. | 登録日 | 2016-03-03 | 公開日 | 2016-08-24 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate. Structure, 24, 2016
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6MMS
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.38 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMV
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.71 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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5I57
| Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains | 分子名称: | GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... | 著者 | Mou, T.-C, Sprang, S.R, Hansen, K.B. | 登録日 | 2016-02-14 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
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5I58
| GLUTAMATE- AND GLYCINE-BOUND GLUN1/GLUN2A AGONIST BINDING DOMAINS WITH MPX-004 | 分子名称: | 5-({[(3-chloro-4-fluorophenyl)sulfonyl]amino}methyl)-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, GLYCINE, ... | 著者 | Mou, T.-C, Sprang, S.R, Hansen, K.B. | 登録日 | 2016-02-14 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
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5IOV
| Cryo-EM structure of GluN1/GluN2B NMDA receptor in the glutamate/glycine/Ro25-6981-bound conformation | 分子名称: | 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, GLUTAMIC ACID, GLYCINE, ... | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, Mchaourab, S.H, Gouaux, E. | 登録日 | 2016-03-09 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
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5IPV
| Cryo-EM structure of GluN1/GluN2B NMDA receptor in the DCKA/D-APV-bound conformation, state 1 | 分子名称: | Ionotropic glutamate receptor subunit NR2B, N-methyl-D-aspartate receptor subunit NR1-8a | 著者 | Zhu, S, Stein, A.R, Yoshioka, C, Lee, C.H, Goehring, A, McHaourab, S.H, Gouaux, E. | 登録日 | 2016-03-10 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (9.25 Å) | 主引用文献 | Mechanism of NMDA Receptor Inhibition and Activation. Cell, 165, 2016
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5JTY
| Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007 | 分子名称: | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide, GLUTAMIC ACID, ... | 著者 | Mou, T.-C, Sprang, S.R, Hansen, K.B. | 登録日 | 2016-05-10 | 公開日 | 2016-09-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron, 91, 2016
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6MMA
| Diheteromeric NMDA receptor GluN1/GluN2A in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-29 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.31 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMT
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (7.46 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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5L1F
| AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor Perampanel | 分子名称: | 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | 登録日 | 2016-07-29 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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5L1E
| AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor CP465022 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino)methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one, Glutamate receptor 2 | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | 登録日 | 2016-07-29 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4.37 Å) | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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6LU9
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6MML
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (7.14 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMP
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 0.1 millimolar EDTA, and at pH 8.0 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.88 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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5L1G
| AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br | 分子名称: | (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2 | 著者 | Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I. | 登録日 | 2016-07-29 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (4.507 Å) | 主引用文献 | Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91, 2016
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6MMN
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 8.0 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (7.51 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMG
| Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.23 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMX
| Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the 'Extended' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-10-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.99 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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6MMJ
| Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (16.5 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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5KUH
| GluK2EM with LY466195 | 分子名称: | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, Glutamate receptor ionotropic, kainate 2 | 著者 | Meyerson, J.R, Chittori, S, Merk, A, Rao, P, Han, T.H, Serpe, M, Mayer, M.L, Subramaniam, S. | 登録日 | 2016-07-13 | 公開日 | 2016-09-07 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (11.6 Å) | 主引用文献 | Structural basis of kainate subtype glutamate receptor desensitization. Nature, 537, 2016
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6MMK
| Diheteromeric NMDA receptor GluN1/GluN2A in the '1-Knuckle' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. | 登録日 | 2018-09-30 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.08 Å) | 主引用文献 | Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
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