5L1E

AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor CP465022

Summary for 5L1E

Entry DOI	10.2210/pdb5l1e/pdb
Related	5L1B 5L1F 5L1G 5L1H
Descriptor	Glutamate receptor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino)methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one (3 entities in total)
Functional Keywords	transporter, membrane protein, transport protein, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	361967.62
Authors	Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Sobolevsky, A.I. (deposition date: 2016-07-29, release date: 2016-10-19, Last modification date: 2023-10-04)
Primary citation	Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Narangoda, C.,Kurnikova, M.,Sobolevsky, A.I. Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91:1305-1315, 2016 Cited by PubMed: 27618672 DOI: 10.1016/j.neuron.2016.08.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.37 Å)

Structure validation