PDB: 1491 件ウェブページステータス検索Chemie searchBIRD

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6WO1	Hybrid acetohydroxyacid synthase complex structure with Cryptococcus neoformans AHAS catalytic subunit and Saccharomyces cerevisiae AHAS regulatory subunit 分子名称: 2-methylpyrimidin-4-amine, Acetohydroxyacid synthase catalytic subunit, Acetohydroxyacid synthase regulatory subunit, ... 著者 Guddat, L.W, Lonhienne, T. 登録日 2020-04-23 公開日 2020-07-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structures of fungal and plant acetohydroxyacid synthases. Nature, 586, 2020
6LPI	Crystal Structure of AHAS holo-enzyme 分子名称: Acetolactate synthase isozyme 1 large subunit, Acetolactate synthase isozyme 1 small subunit, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Zhang, Y, Yang, X, Xi, Z, Shen, Y. 登録日 2020-01-10 公開日 2020-11-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.849 Å) 主引用文献 Molecular architecture of the acetohydroxyacid synthase holoenzyme. Biochem.J., 477, 2020
5YPP	Crystal structure of IlvN.Val-1a 分子名称: ACETATE ION, Acetolactate synthase isozyme 1 small subunit, DI(HYDROXYETHYL)ETHER, ... 著者 Sarma, S.P, Bansal, A, Schindelin, H, Demeler, B. 登録日 2017-11-02 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases. Biochemistry, 58, 2019
5YPW	Crystal structure of IlvN.Val-1b 分子名称: Acetolactate synthase isozyme 1 small subunit, VALINE 著者 Sarma, S.P, Bansal, A, Schindelin, H, Demeler, B. 登録日 2017-11-03 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases. Biochemistry, 58, 2019
5YPY	Crystal structure of IlvN. Val-1c 分子名称: Acetolactate synthase isozyme 1 small subunit, VALINE 著者 Sarma, S.P, Bansal, A, Schindelin, H, Demeler, B. 登録日 2017-11-04 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.966 Å) 主引用文献 Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases. Biochemistry, 58, 2019
4LVC	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii in complex with adenosine 分子名称: ACETATE ION, ADENOSINE, AMMONIUM ION, ... 著者 Manszewski, T, Singh, K, Imiolczyk, B, Jaskolski, M. 登録日 2013-07-26 公開日 2014-07-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii. Acta Crystallogr.,Sect.D, 71, 2015
4ZY3	Crystal Structure of Keap1 in Complex with a small chemical compound, K67 分子名称: FORMIC ACID, Kelch-like ECH-associated protein 1, N,N'-[2-(2-oxopropyl)naphthalene-1,4-diyl]bis(4-ethoxybenzenesulfonamide) 著者 Fukutomi, T, Iso, T, Suzuki, T, Takagi, K, Mizushima, T, Komatsu, M, Yamamoto, M. 登録日 2015-05-21 公開日 2016-05-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Nat Commun, 7, 2016
8IB1	Structure of the LAH31 Fab bound to an influenza virus HA epitope peptide 分子名称: Hemagglutinin HA2 chain, LAH31 Fab heavy chain, LAH31 Fab light chain 著者 Suzuki, T, Hashiguchi, T. 登録日 2023-02-09 公開日 2023-07-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope. Plos Pathog., 19, 2023
8IIA	Crystal structure of the oligomeric state of the extracellular domain of human myelin protein zero(MPZ/P0) 分子名称: GLYCEROL, Myelin protein P0 著者 Sakakura, M, Tanabe, M, Mio, K. 登録日 2023-02-24 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural bases for the Charcot-Marie-Tooth disease induced by single amino acid substitutions of myelin protein zero. Structure, 31, 2023
1MWE	THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, N-acetyl-alpha-neuraminic acid, ... 著者 Varghese, J.N. 登録日 1997-08-27 公開日 1998-03-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases. Proc.Natl.Acad.Sci.USA, 94, 1997
5WJJ	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors 分子名称: Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide 著者 Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. 登録日 2017-07-23 公開日 2018-01-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
4QFG	Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-20 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4QFR	Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor 分子名称: 2-chloro-4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-21 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
5AA3	Crystal structure of MltF from Pseudomonas aeruginosa in the presence of tetrasaccharide and tetrapeptide 分子名称: GLUTAMIC ACID, MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F 著者 Dominguez-Gil, T, Acebron, I, Hermoso, J.A. 登録日 2015-07-23 公開日 2016-10-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. Structure, 24, 2016
5A5X	Crystal Structure of Se-Met MltF from Pseudomonas aeruginosa 分子名称: 1,2-ETHANEDIOL, MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F 著者 Dominguez-Gil, T, Acebron, I, Hermoso, J.A. 登録日 2015-06-23 公開日 2016-10-12 最終更新日 2017-03-22 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. Structure, 24, 2016
4QFS	Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor 分子名称: 2-bromo-3-(4-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-21 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.55 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
6VHF	Crystal structure of RbBP5 interacting domain of Cfp1 分子名称: PHD-type domain-containing protein, ZINC ION 著者 Joshi, M, Couture, J.F. 登録日 2020-01-09 公開日 2020-01-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.311 Å) 主引用文献 A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS. Nucleic Acids Res., 48, 2020
5OIZ	Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae in complex with oxacillin 分子名称: (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Penicillin-binding protein 2X 著者 Bernardo-Garcia, N, Hermoso, J.A. 登録日 2017-07-20 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol., 13, 2018
5OJ1	Penicillin Binding Protein 2x (PBP2x) from S.pneumoniae in complex with Oxacillin and a tetrasaccharide 分子名称: (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Penicillin-binding protein 2X, SODIUM ION 著者 Bernardo-Garcia, N, Hermoso, J.A. 登録日 2017-07-20 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol., 13, 2018
6VME	Human ESCRT-I heterotetramer headpiece 分子名称: Multivesicular body subunit 12A, Tumor susceptibility gene 101 protein, Vacuolar protein sorting-associated protein 28 homolog, ... 著者 Flower, T.G, Hurley, J.H, Tjahjono, N. 登録日 2020-01-27 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. Nat.Struct.Mol.Biol., 27, 2020
4K60	Crystal Structure of Human Chymase in Complex with Fragment 6-bromo-1,3-dihydro-2H-indol-2-one 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-bromo-1,3-dihydro-2H-indol-2-one, Chymase, ... 著者 Collins, B.K, Padyana, A.K. 登録日 2013-04-15 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56, 2013
5OJ0	Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae in complex with Cefepime 分子名称: Cefepime, Penicillin-binding protein 2X 著者 Bernardo-Garcia, N, Hermoso, J.A. 登録日 2017-07-20 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol., 13, 2018
5OHU	The X-ray Structure of Lytic Transglycosylase Slt from Pseudomonas aeruginosa 分子名称: PHOSPHATE ION, Soluble lytic murein transglycosylase 著者 Batuecas, M.T, Dominguez-Gil, T, Hermoso, J.A. 登録日 2017-07-18 公開日 2018-04-18 最終更新日 2018-05-02 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt ofPseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4K5Z	Crystal Structure of Human Chymase in Complex with Fragment Inhibitor 6-chloro-2,3-dihydro-1H-isoindol-1-one 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-chloro-2,3-dihydro-1H-isoindol-1-one, Chymase, ... 著者 Collins, B.K, Padyana, A.K. 登録日 2013-04-15 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56, 2013
4K69	Crystal Structure of Human Chymase in Complex with Fragment Linked Benzimidazolone Inhibitor: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid 分子名称: (3S)-3-{3-[(6-bromo-2-oxo-2,3-dihydro-1H-indol-4-yl)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}hexanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Chymase, ... 著者 Collins, B.K, Padyana, A.K. 登録日 2013-04-15 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J.Med.Chem., 56, 2013

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