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5OJ1

Penicillin Binding Protein 2x (PBP2x) from S.pneumoniae in complex with Oxacillin and a tetrasaccharide

Summary for 5OJ1
Entry DOI10.2210/pdb5oj1/pdb
DescriptorPenicillin-binding protein 2X, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, SODIUM ION, ... (4 entities in total)
Functional Keywordspenicillin-binding-protein, cell-wall, antibiotic
Biological sourceStreptococcus pneumoniae R6
Cellular locationCell membrane; Single-pass membrane protein: P59676
Total number of polymer chains1
Total formula weight77234.41
Authors
Bernardo-Garcia, N.,Hermoso, J.A. (deposition date: 2017-07-20, release date: 2018-05-30, Last modification date: 2024-01-17)
Primary citationBernardo-Garcia, N.,Mahasenan, K.V.,Batuecas, M.T.,Lee, M.,Hesek, D.,Petrackova, D.,Doubravova, L.,Branny, P.,Mobashery, S.,Hermoso, J.A.
Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae.
ACS Chem. Biol., 13:694-702, 2018
Cited by
PubMed: 29357220
DOI: 10.1021/acschembio.7b00817
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.85 Å)
Structure validation

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