5OJ1
Penicillin Binding Protein 2x (PBP2x) from S.pneumoniae in complex with Oxacillin and a tetrasaccharide
Summary for 5OJ1
Entry DOI | 10.2210/pdb5oj1/pdb |
Descriptor | Penicillin-binding protein 2X, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, SODIUM ION, ... (4 entities in total) |
Functional Keywords | penicillin-binding-protein, cell-wall, antibiotic |
Biological source | Streptococcus pneumoniae R6 |
Cellular location | Cell membrane; Single-pass membrane protein: P59676 |
Total number of polymer chains | 1 |
Total formula weight | 77234.41 |
Authors | Bernardo-Garcia, N.,Hermoso, J.A. (deposition date: 2017-07-20, release date: 2018-05-30, Last modification date: 2024-01-17) |
Primary citation | Bernardo-Garcia, N.,Mahasenan, K.V.,Batuecas, M.T.,Lee, M.,Hesek, D.,Petrackova, D.,Doubravova, L.,Branny, P.,Mobashery, S.,Hermoso, J.A. Allostery, Recognition of Nascent Peptidoglycan, and Cross-linking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. ACS Chem. Biol., 13:694-702, 2018 Cited by PubMed: 29357220DOI: 10.1021/acschembio.7b00817 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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