PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

---

6OSM	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103 分子名称: Alpha-synuclein 著者 Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. 登録日 2019-05-01 公開日 2019-09-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
3ZRF	pVHL54-213-EloB-EloC complex_apo 分子名称: TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, 著者 Van Molle, I, Buckley, D.L, Crews, C.M, Ciulli, A. 登録日 2011-06-16 公開日 2012-03-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134, 2012
3HV3	Human p38 MAP Kinase in Complex with RL49 分子名称: 1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1H-pyrazol-5-yl]urea, GLYCEROL, Mitogen-activated protein kinase 14, ... 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2009-06-15 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
6Q7T	ERK2 mini-fragment binding 分子名称: 1,2-oxazol-3-amine, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-13 公開日 2019-06-26 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
1TR4	Solution structure of human oncogenic protein gankyrin 分子名称: 26S proteasome non-ATPase regulatory subunit 10 著者 Yuan, C, Li, J, Mahajan, A, Poi, M.J, Byeon, I.J, Tsai, M.D. 登録日 2004-06-19 公開日 2004-11-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship. Biochemistry, 43, 2004
6QAH	ERK2 mini-fragment binding 分子名称: 1-azanylpropylideneazanium, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-19 公開日 2019-06-26 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
5VTB	Crystal structure of RBBP4 bound to BCL11a peptide 分子名称: B-cell lymphoma/leukemia 11A, GLYCEROL, Histone-binding protein RBBP4 著者 Meagher, J.L, Stuckey, J.A. 登録日 2017-05-16 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Probing the interaction between the histone methyltransferase/deacetylase subunit RBBP4/7 and the transcription factor BCL11A in epigenetic complexes. J. Biol. Chem., 293, 2018
4FMQ	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: MAPK DOCKING PEPTIDE, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Gogl, G, Toeroe, I, Remenyi, A. 登録日 2012-06-18 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) 分子名称: Alpha-synuclein 著者 Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. 登録日 2019-05-01 公開日 2019-09-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6OSL	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122 分子名称: Alpha-synuclein 著者 Ni, X, McGlinchey, R.P, Jiang, J, Lee, J.C. 登録日 2019-05-01 公開日 2019-09-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
7UAS	Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization 分子名称: (5P)-2-[(S)-cyclopropyl(4-methylpyridin-2-yl)methyl]-5-[1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, WD repeat-containing protein 5 著者 Zhao, B. 登録日 2022-03-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.808 Å) 主引用文献 Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
6O6W	Solution structure of human myeloid-derived growth factor 分子名称: Myeloid-derived growth factor 著者 Bortnov, V, Tonelli, M, Lee, W, Markley, J.L, Mosher, D.F. 登録日 2019-03-07 公開日 2019-11-13 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum. Nat Commun, 10, 2019
4GVA	ADP-bound form of the ERK2 kinase 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Mitogen-activated protein kinase 1 著者 Pozharski, E, Zhang, J, Shapiro, P. 登録日 2012-08-30 公開日 2012-09-12 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 ADP-bound form of the ERK2 kinase TO BE PUBLISHED
1M3Q	Crystal Structure of hogg1 D268E Mutant with Base-Excised DNA and 8-aminoguanine 分子名称: 5'-D(*GP*CP*GP*TP*CP*CP*AP*(DRZ)P*GP*TP*CP*TP*AP*CP*C)-3', 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*C)-3', 8-AMINOGUANINE, ... 著者 Chung, S.J, Verdine, G.L. 登録日 2002-06-28 公開日 2004-02-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of End Products Resulting from Lesion Processing by a DNA Glycosylase/Lyase Chem.Biol., 11, 2004
7DR4	Complex of anti-human IL-2 antibody and human IL-2 分子名称: Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ... 著者 Kim, M.S, Kim, J.E. 登録日 2020-12-25 公開日 2021-04-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity. Oncoimmunology, 10, 2021
7SID	Human ATM Dimer Bound to Nbs1 分子名称: MAGNESIUM ION, Nibrin, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Warren, C, Pavletich, N.P. 登録日 2021-10-13 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.53 Å) 主引用文献 Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife, 11, 2022
7SIC	Human ATM Dimer 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM 著者 Warren, C, Pavletich, N.P. 登録日 2021-10-13 公開日 2022-02-02 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.51 Å) 主引用文献 Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife, 11, 2022
6RFP	ERK2 MAP kinase with mutations at Helix-G 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Eitan-Wexler, M. 登録日 2019-04-16 公開日 2020-05-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop. J.Biol.Chem., 295, 2020
4H3P	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 著者 Gogl, G, Toeroe, I, Remenyi, A. 登録日 2012-09-14 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Protein-peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase Acta Crystallogr.,Sect.D, 69, 2013
6RQ4	Inhibitor of ERK2 分子名称: 6,6-dimethyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-5-(2-morpholin-4-ylethyl)thieno[2,3-c]pyrrol-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2019-05-15 公開日 2019-12-04 最終更新日 2020-02-19 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2. Mol.Cancer Ther., 19, 2020
4GSB	Monoclinic crystal form of the apo-ERK2 分子名称: GLYCEROL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Pozharski, E, Zhang, J, Shapiro, P. 登録日 2012-08-27 公開日 2012-09-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Monoclinic crystal form of the apo-ERK2 TO BE PUBLISHED
6R1T	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 1, free nuclesome 分子名称: DNA (147-MER), HISTONE H2A, Histone H2A, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.02 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
3ZRC	pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound 分子名称: (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, ... 著者 Van Molle, I, Buckley, D.L, Crews, C.M, Ciulli, A. 登録日 2011-06-15 公開日 2012-03-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134, 2012
2HDE	Solution Structure of Human SAP18 分子名称: Histone deacetylase complex subunit SAP18 著者 McCallum, S.A, Yin, J.P, Pan, B, Fairbrother, W.J. 登録日 2006-06-20 公開日 2007-04-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. Biochemistry, 45, 2006
4GT3	ATP-bound form of the ERK2 kinase 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Pozharski, E, Zhang, J, Shapiro, P. 登録日 2012-08-28 公開日 2012-09-12 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 ATP-bound form of the ERK2 kinase TO BE PUBLISHED

<217218219220221222223224225226227228229230231232>