PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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3H4C	Structure of the C-terminal Domain of Transcription Factor IIB from Trypanosoma brucei 分子名称: 1,2-ETHANEDIOL, Transcription factor TFIIB-like 著者 Syed Ibrahim, B, Kanneganti, N, Rieckhof, G.E, Das, A, Laurents, D.V, Palenchar, J.B, Bellofatto, V, Wah, D.A. 登録日 2009-04-18 公開日 2009-08-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei. Proc.Natl.Acad.Sci.USA, 106, 2009
7NHT	Akirin2 bound human proteasome 分子名称: Akirin-2, POTASSIUM ION, Proteasome subunit alpha type-1, ... 著者 Singh, K, Brunner, H, Grishkovskaya, I, de Almeida, M, Hinterndorfer, M, Zuber, J, Haselbach, D. 登録日 2021-02-11 公開日 2021-09-01 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 AKIRIN2 controls the nuclear import of proteasomes in vertebrates. Nature, 599, 2021
6K08	Crystal structure of REV7(R124A/A135D) in complex with a Shieldin3 fragment 分子名称: Mitotic spindle assembly checkpoint protein MAD2B, SULFATE ION, Shieldin complex subunit 3 著者 Zhang, F, Dai, Y. 登録日 2019-05-05 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.312 Å) 主引用文献 Structural basis for shieldin complex subunit 3-mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair. J.Biol.Chem., 295, 2020
3QWP	Crystal structure of SET and MYND domain containing 3; Zinc finger MYND domain-containing protein 1 分子名称: GLYCEROL, S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ... 著者 Dong, A, Dombrovski, L, Li, Y, Wernimont, A, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-02-28 公開日 2011-04-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 The Crystal Structure of human Histone-lysine N-methyltransferase SMYD3 To be Published
7Z8B	Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation 分子名称: Cullin-7, E3 ubiquitin-protein ligase RBX1, F-box/WD repeat-containing protein 8, ... 著者 Hopf, L.V.M, Schulman, B.A. 登録日 2022-03-17 公開日 2022-08-24 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of CRL7 FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nat.Struct.Mol.Biol., 29, 2022
3AJI	Structure of Gankyrin-S6ATPase photo-cross-linked site-specifically, and incoporated by genetic code expansion 分子名称: 26S proteasome non-ATPase regulatory subunit 10, Proteasome (Prosome, macropain) 26S subunit, ... 著者 Sato, S, Mimasu, S, Sato, A, Hino, N, Sakamoto, K, Umehara, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2010-06-07 公開日 2010-12-22 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystallographic study of a site-specifically cross-linked protein complex with a genetically incorporated photoreactive amino acid Biochemistry, 50, 2011
4QP1	Crystal structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine 分子名称: IMIDAZOLE, Mitogen-activated protein kinase 1, N-BENZYL-9H-PURIN-6-AMINE 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP9	Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine 分子名称: 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
3PDN	Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin 分子名称: GLYCEROL, MAGNESIUM ION, SET and MYND domain-containing protein 3, ... 著者 Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2010-10-23 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3. J.Mol.Biol., 406, 2011
4QP7	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine 分子名称: 2-(1H-pyrazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.249 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP4	Crystal Structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine 分子名称: Mitogen-activated protein kinase 1, N-cyclohexyl-9H-purin-6-amine 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QPA	Crystal Structure of ERK2 in complex with 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine 分子名称: 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP3	Crystal Structure of ERK2 in complex with (S)-2-((9H-purin-6-yl)amino)-3-phenylpropan-1-ol 分子名称: (2S)-3-phenyl-2-(9H-purin-6-ylamino)propan-1-ol, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (2.599 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP6	Crystal Structure of ERK2 in complex with 5H-pyrrolo[2,3-b]pyrazine 分子名称: 5H-pyrrolo[2,3-b]pyrazine, IMIDAZOLE, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP8	Crystal Structure of ERK2 in complex with 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine 分子名称: 2-(1H-pyrazol-4-yl)-7-(pyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.446 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QP2	Crystal Structure of ERKs in complex with 5-chlorobenzo[d]oxazol-2-amine 分子名称: 5-chloro-1,3-benzoxazol-2-amine, IMIDAZOLE, Mitogen-activated protein kinase 1 著者 Yin, J, Wang, W. 登録日 2014-06-22 公開日 2015-09-23 最終更新日 2015-12-16 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4QYY	Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State 分子名称: (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. 登録日 2014-07-26 公開日 2014-11-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
1Q21	CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF THE CATALYTIC DOMAINS OF NORMAL RAS PROTEIN AND AN ONCOGENIC MUTANT COMPLEXED WITH GSP 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J.Mol.Biol., 217, 1991
1QYM	X-ray structure of human gankyrin 分子名称: 26S proteasome non-ATPase regulatory subunit 10 著者 Manjasetty, B.A, Quedenau, C, Sievert, V, Buessow, K, Niesen, F, Delbrueck, H, Heinemann, U. 登録日 2003-09-11 公開日 2003-11-18 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 X-ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma. Proteins, 55, 2004
8TU6	CryoEM structure of PI3Kalpha 分子名称: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Valverde, R, Shi, H, Holliday, M. 登録日 2023-08-15 公開日 2023-11-15 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia. Cancer Discov, 14, 2024
8F93	WDR5 covalently modified at Y228 by (R)-2-SF 分子名称: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... 著者 Taunton, J, Craven, G.B, Chen, Y. 登録日 2022-11-23 公開日 2023-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
4ERK	THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE 分子名称: EXTRACELLULAR REGULATED KINASE 2, OLOMOUCINE, SULFATE ION 著者 Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J. 登録日 1998-07-09 公開日 1999-07-22 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of inhibitor selectivity in MAP kinases. Structure, 6, 1998
7T91	Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region 分子名称: Isoform 2 of Zinc finger protein GLI1, ZINC ION 著者 Wu, M, Zhang, S, Augelli-Szanfran, C.E, Boohaker, R.J. 登録日 2021-12-17 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region To Be Published
6Q7K	ERK2 mini-fragment binding 分子名称: 1H-imidazol-2-amine, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-13 公開日 2019-03-27 最終更新日 2019-05-22 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
2BZE	NMR Structure of human RTF1 PLUS3 domain. 分子名称: KIAA0252 PROTEIN 著者 Truffault, V, Diercks, T, Ab, E, De Jong, R.N, Daniels, M.A, Kaptein, R, Folkers, G.E, Structural Proteomics in Europe (SPINE) 登録日 2005-08-16 公開日 2007-01-03 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structure and DNA Binding of the Human Rtf1 Plus3 Domain. Structure, 16, 2008

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