7L2T
| cryo-EM structure of DkTx-bound minimal TRPV1 in partial open state | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2P
| cryo-EM structure of unliganded minimal TRPV1 | 分子名称: | (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7FBS
| structure of a channel | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1-[2-[(2R)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D.J, Catterall, W.A. | 登録日 | 2021-07-12 | 公開日 | 2021-09-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Open-state structure and pore gating mechanism of the cardiac sodium channel. Cell, 184, 2021
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7M6A
| High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Melville, Z, Kim, K, Clarke, O.B, Marks, A.R. | 登録日 | 2021-03-25 | 公開日 | 2021-09-08 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure, 30, 2022
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7RAS
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7RAU
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7M6L
| High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | 著者 | Melville, Z, Kim, K, Clarke, O.B, Marks, A.R. | 登録日 | 2021-03-25 | 公開日 | 2021-08-18 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure, 30, 2022
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7AA5
| Human TRPV4 structure in presence of 4a-PDD | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily V member 4,Green fluorescent protein | 著者 | Botte, M, Ulrich, A.K.G, Adaixo, R, Gnutt, D, Brockmann, A, Bucher, D, Chami, M, Bocquet, M, Ebbinghaus-Kintscher, U, Puetter, V, Becker, A, Egner, U, Stahlberg, H, Hennig, M, Holton, S.J. | 登録日 | 2020-09-03 | 公開日 | 2021-08-18 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation To Be Published
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7NP4
| cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Giese, H, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | 登録日 | 2021-02-26 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021
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7NP3
| cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Giese, H.M, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | 登録日 | 2021-02-26 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021
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7EEB
| Structure of the CatSpermasome | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, J.P, Ke, M. | 登録日 | 2021-03-18 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of a mammalian sperm cation channel complex. Nature, 595, 2021
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7LPE
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPB
| Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPD
| Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPA
| Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LP9
| Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7LPC
| Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7MIL
| Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIO
| Mouse TRPV3 in cNW11 nanodiscs, open state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIJ
| Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (1.98 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIK
| Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIN
| Mouse TRPV3 in cNW11 nanodiscs, closed state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MIM
| Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MBR
| Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (apo state) | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | 登録日 | 2021-04-01 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBS
| Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (open state) | 分子名称: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ruan, Z, Lu, W, Du, J, Haley, E. | 登録日 | 2021-04-01 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY | 主引用文献 | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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