7AN5
 
 | | Enzyme of biosynthetic pathway | | 分子名称: | 3-[(1-Carboxyvinyl)oxy]benzoic acid, Chorismate dehydratase | | 著者 | Archna, A, Breithaupt, C, Stubbs, M.T. | | 登録日 | 2020-10-11 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis
J.Biol.Chem., 2022
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5WNE
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5VBE
 | | Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GDP | | 分子名称: | 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Gentile, D.R, Jenkins, M.L, Moss, S.M, Burke, J.E, Shokat, K.M. | | 登録日 | 2017-03-29 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Cell Chem Biol, 24, 2017
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9E5M
 | | env2 cobalamin riboswitch aptamer domain in complex with ethynyl-4,1'-biphenyl-cobalamin | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, N-methylpropane-1,3-diamine, ... | | 著者 | Olenginski, L.T, Batey, R.T. | | 登録日 | 2024-10-28 | | 公開日 | 2025-09-24 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Designing small molecules targeting a cryptic RNA binding site through base displacement.
Nat.Chem.Biol., 2025
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7UEB
 | | Photosynthetic assembly of Chlorobaculum tepidum (RC-FMO2) | | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaenyl]-1,3,4-trimethyl-benzene, ... | | 著者 | Puskar, R, Truong, C.D, Swain, K, Li, S, Cheng, K.-W, Wang, T.Y, Poh, Y.-P, Liu, H, Chou, T.-F, Nannenga, B, Chiu, P.-L. | | 登録日 | 2022-03-21 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria.
Nat Commun, 13, 2022
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5AQZ
 | | HSP72 with adenosine-derived inhibitor | | 分子名称: | 1,2-ETHANEDIOL, HEAT SHOCK 70 KDA PROTEIN 1A, SANGIVAMYCIN | | 著者 | Cheeseman, M.D, Westwood, I.M, Barbeau, O, Rowlands, M.G, Jones, A.M, Jeganathan, F, Burke, R, Dobson, S.E, Workman, P, Collins, I, van Montfort, R.L.M, Jones, K. | | 登録日 | 2015-09-22 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70.
J.Med.Chem., 59, 2016
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7LP5
 | | Structure of Nedd4L WW3 domain | | 分子名称: | Angiomotin,E3 ubiquitin-protein ligase NEDD4-like | | 著者 | Alam, S.L, Alian, A, Thompson, T, Rheinemann, L, Volkman, B.F, Peterson, F.C, Sundquist, W.I. | | 登録日 | 2021-02-11 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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7UEA
 | | Photosynthetic assembly of Chlorobaculum tepidum (RC-FMO1) | | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaenyl]-1,3,4-trimethyl-benzene, ... | | 著者 | Puskar, R, Truong, C.D, Swain, K, Li, S, Cheng, K.-W, Wang, T.Y, Poh, Y.-P, Liu, H, Chou, T.-F, Nannenga, B, Chiu, P.-L. | | 登録日 | 2022-03-21 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria.
Nat Commun, 13, 2022
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6FU2
 | | ATP phosphoribosyltransferase (HisZG ATPPRT) from Psychrobacter arcticus in complex with PRPP and ATP | | 分子名称: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Alphey, M.S, Ge, Y, Fisher, G, Czekster, C.M, Naismith, J.H, da Silva, R.G. | | 登録日 | 2018-02-26 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Catalytic and Anticatalytic Snapshots of a Short-Form ATP Phosphoribosyltransferase
Acs Catalysis, 2018
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7AN9
 | | Enzyme of biosynthetic pathway | | 分子名称: | 3-[(1-Carboxyvinyl)oxy]benzoic acid, Chorismate dehydratase | | 著者 | Archna, A, Breithaupt, C, Stubbs, M.T. | | 登録日 | 2020-10-11 | | 公開日 | 2022-04-20 | | 最終更新日 | 2025-10-22 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis.
J.Biol.Chem., 298, 2022
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4Q5T
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6DQN
 | | Class 1 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | | 著者 | Hite, R.K, Paknejad, N. | | 登録日 | 2018-06-11 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3.
Nat. Struct. Mol. Biol., 25, 2018
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3DO5
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2PNG
 | | Type I rat fatty acid synthase acyl carrier protein (ACP) domain | | 分子名称: | Fatty acid synthase (EC 2.3.1.85) | | 著者 | Ploskon, E.A, Arthur, C.J, Evans, S.E, Williams, C, Crosby, J, Crump, M.P. | | 登録日 | 2007-04-24 | | 公開日 | 2007-06-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Mammalian type I Fatty Acid synthase acyl carrier protein domain does not sequester acyl chains.
J.Biol.Chem., 283, 2008
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7GI8
 | | Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MIC-UNK-45817b9b-1 (Mpro-P0060) | | 分子名称: | (4R)-6-chloro-N-(isoquinolin-4-yl)-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ... | | 著者 | Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-08 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
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5UZJ
 | | Crystal Structure of ROCK1 bound to an aminopyridine inhibitor | | 分子名称: | N-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide, Rho-associated protein kinase 1 | | 著者 | Jacobs, M.D. | | 登録日 | 2017-02-26 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
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3DUX
 | | Understanding Thrombin Inhibition | | 分子名称: | 3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide, Hirudin variant-1, SODIUM ION, ... | | 著者 | Baum, B, Heine, A, Klebe, G. | | 登録日 | 2008-07-18 | | 公開日 | 2009-06-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin
J.Mol.Biol., 391, 2009
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7SQ9
 | | Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution | | 分子名称: | (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gan, N, Han, Y, Jiang, Y. | | 登録日 | 2021-11-04 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | | 主引用文献 | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5WUK
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4KQ2
 | | Glucose1,2cyclic phosphate bound activated state of Yeast Glycogen Synthase | | 分子名称: | (2R,3aR,5R,6S,7S,7aR)-5-(hydroxymethyl)tetrahydro-3aH-[1,3,2]dioxaphospholo[4,5-b]pyran-2,6,7-triol 2-oxide, 6-O-phosphono-alpha-D-glucopyranose, BARIUM ION, ... | | 著者 | Chikwana, V.M, Hurley, T.D. | | 登録日 | 2013-05-14 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3DXQ
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2Q9Y
 | | Trichodiene synthase: Complex with Mg, inorganic pyrophosphate, and benzyl triethyl ammonium cation | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, ... | | 著者 | Vedula, L.S, Zhao, Y, Coates, R.M, Koyama, T, Cane, D.E, Christianson, D.W. | | 登録日 | 2007-06-14 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Exploring biosynthetic diversity with trichodiene synthase.
Arch.Biochem.Biophys., 466, 2007
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8Y38
 | | Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | 登録日 | 2024-01-28 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | | 主引用文献 | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
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7XGS
 | | Short vegetative phase protein | | 分子名称: | 1,2-ETHANEDIOL, MADS-box protein SVP | | 著者 | Liao, Y.-T, Wang, H.-C, Ko, T.-P. | | 登録日 | 2022-04-06 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | The PHYL1 effector of peanut witches broom (PnWB) phytoplasma alters the miR156/157-mediated squamosa promoter binding protein like regulation and gibberellic acid generation to promote anthocyanin biosynthesis
To Be Published
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6DQZ
 | | Class 4 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor | | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ZINC ION | | 著者 | Hite, R.K, Paknejad, N. | | 登録日 | 2018-06-11 | | 公開日 | 2018-08-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (6.01 Å) | | 主引用文献 | Structural basis for the regulation of inositol trisphosphate receptors by Ca2+and IP3.
Nat. Struct. Mol. Biol., 25, 2018
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