5UZJ

Crystal Structure of ROCK1 bound to an aminopyridine inhibitor

Summary for 5UZJ

• Entry DOI: 10.2210/pdb5uzj/pdb
• Related: 5UZK
• Descriptor: Rho-associated protein kinase 1, N-[4-(2-aminopyridin-4-yl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide (3 entities in total)
• Functional Keywords: dimerization, dimer, phosphorylation, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 96705.37

Authors

Jacobs, M.D. (deposition date: 2017-02-26, release date: 2018-03-07, Last modification date: 2023-10-04)

Primary citation

Bandarage, U.K.,Cao, J.,Come, J.H.,Court, J.J.,Gao, H.,Jacobs, M.D.,Marhefka, C.,Nanthakumar, S.,Green, J.
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors.
Bioorg. Med. Chem. Lett., 28:2622-2626, 2018

PubMed Abstract: Rho kinase (ROCK) inhibitors are potential therapeutic agents for the treatment of a variety of disorders including hypertension, glaucoma and erectile dysfunction. Here we disclose a series of potent and selective ROCK inhibitors based on a substituted 7-azaindole scaffold. Substitution of the 3-position of 7-azaindole led to compounds such as 37, which possess excellent ROCK inhibitory potency and high selectivity against the closely related kinase PKA.

PubMed: 30082069
DOI: 10.1016/j.bmcl.2018.06.040

Experimental method

X-RAY DIFFRACTION (3.3 Å)