PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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6R25	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 3 分子名称: DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, H2B, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 実験手法 ELECTRON MICROSCOPY (4.61 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
6BYN	Crystal structure of WDR5-Mb(S4) monobody complex 分子名称: WD repeat-containing protein 5, WDR5-binding Monobody, Mb(S4) 著者 Gupta, A, Koide, S. 登録日 2017-12-21 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Facile target validation in an animal model with intracellularly expressed monobodies. Nat. Chem. Biol., 14, 2018
2B90	Crystal structure of the interleukin-4 variant T13DR85A 分子名称: Interleukin-4, SULFATE ION 著者 Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. 登録日 2005-10-10 公開日 2006-05-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor Bmc Biol., 4, 2006
2B8U	Crystal structure of wildtype human Interleukin-4 分子名称: Interleukin-4, SULFATE ION 著者 Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. 登録日 2005-10-10 公開日 2006-05-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor Bmc Biol., 4, 2006
2B8Y	Crystal structure of the interleukin-4 variant T13DF82D 分子名称: Interleukin-4, SULFATE ION 著者 Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. 登録日 2005-10-10 公開日 2006-05-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor Bmc Biol., 4, 2006
2B91	Crystal structure of the interleukin-4 variant F82DR85A 分子名称: Interleukin-4, SULFATE ION 著者 Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D. 登録日 2005-10-10 公開日 2006-05-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor Bmc Biol., 4, 2006
4J2X	CSL (RBP-Jk) with corepressor KyoT2 bound to DNA 分子名称: 1,2-ETHANEDIOL, 5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3', 5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3', ... 著者 Collins, K.J, Kovall, R.A. 登録日 2013-02-05 公開日 2013-11-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling. Structure, 22, 2014
4KIQ	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE 分子名称: Mitogen-activated protein kinase 14, ethyl 6-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]carbamoyl}-1H-indole-1-carboxylate 著者 Sack, J.S, Tokarski, J.S. 登録日 2013-05-02 公開日 2013-06-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Identification of Novel P38-Alpha Isoform Selective Kinase Inhibitors Having an Unprecedented P38-Alpha Binding Mode Bioorg.Med.Chem.Lett., 23, 2013
5MLW	Crystal structure of human PCNA in complex with ZRANB3 APIM motif peptide 分子名称: APIM motif peptide, Proliferating cell nuclear antigen, SULFATE ION 著者 Ariza, A. 登録日 2016-12-07 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural insights into the function of ZRANB3 in replication stress response. Nat Commun, 8, 2017
8BYX	HOXB13-homodimer bound to DNA 分子名称: DNA, Homeobox protein Hox-B13 著者 Morgunova, E, Popov, A, Yin, Y, Taipale, J. 登録日 2022-12-14 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 HOXB13-homodimer bound to DNA To Be Published
8ILV	Cryo-EM structure of PI3Kalpha in complex with compound 18 分子名称: N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[3-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. 登録日 2023-03-04 公開日 2023-09-06 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Structural insights into the interaction of three Y-shaped ligands with PI3K alpha. Proc.Natl.Acad.Sci.USA, 120, 2023
3O8U	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding 分子名称: 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-08-03 公開日 2010-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding To be Published
8CR8	human Interleukin-23 分子名称: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, TERBIUM(III) ION, ... 著者 Bloch, Y, Savvides, S.N. 登録日 2023-03-08 公開日 2024-02-07 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
8ILS	Cryo-EM structure of PI3Kalpha in complex with compound 17 分子名称: N-[(2R)-1-(ethylamino)-1-oxidanylidene-3-[4-(2-quinoxalin-6-ylethynyl)phenyl]propan-2-yl]-2,3-dimethyl-quinoxaline-6-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Zhou, Q, Liu, X, Neri, D, Li, W, Favalli, N, Bassi, G, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. 登録日 2023-03-04 公開日 2023-09-13 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the interaction of three Y-shaped ligands with PI3K alpha. Proc.Natl.Acad.Sci.USA, 120, 2023
5MOM	Crystal Structure of PCNA encoding the hypomorphic mutation S228I 分子名称: Proliferating cell nuclear antigen 著者 Biasutto, A.J, Mancini, E.J, Green, C.M, Wilson, R.H.C. 登録日 2016-12-14 公開日 2017-01-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions. DNA Repair (Amst.), 50, 2017
8U8J	Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16 分子名称: (4M)-4-{(4R)-3-[(2S)-2-methylbutyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1 著者 Anderson, J.W, Vigers, G.P. 登録日 2023-09-18 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife, 12, 2024
8U8K	Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #8 分子名称: (4M)-4-{(4S)-3-[(2-chloropyridin-3-yl)methyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(oxan-4-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1 著者 Anderson, J.W, Vigers, G.P. 登録日 2023-09-18 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife, 12, 2024
8PPW	Structure of human PARK7 in complex with GK16S 分子名称: (3~{S})-1-(iminomethyl)-~{N}-pent-4-ynyl-pyrrolidine-3-carboxamide, Parkinson disease protein 7 著者 Grethe, C, Gersch, M. 登録日 2023-07-10 公開日 2024-01-31 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1. Angew.Chem.Int.Ed.Engl., 63, 2024
8F5Q	Crystal structure of human PCNA in complex with the PIP box of FBH1 分子名称: F-box DNA helicase 1, Proliferating cell nuclear antigen 著者 Liu, J, Chaves-Arquero, B, Wei, P, Tencer, H, Zhang, G, Blanco, F, Kutateladze, T. 登録日 2022-11-15 公開日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular insight into the PCNA-binding mode of FBH1. Structure, 31, 2023
3CZ9	Crystal Structure of E18L DJ-1 分子名称: O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, Protein DJ-1 著者 Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hasim, S, Pozharski, E, Wilson, M.A. 登録日 2008-04-28 公開日 2008-07-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Cysteine pKa depression by a protonated glutamic acid in human DJ-1. Biochemistry, 47, 2008
3CYF	Crystal Structure of E18N DJ-1 分子名称: Protein DJ-1 著者 Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hasim, S, Pozharski, E, Wilson, M.A. 登録日 2008-04-25 公開日 2008-07-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Cysteine pKa depression by a protonated glutamic acid in human DJ-1. Biochemistry, 47, 2008
3CZA	Crystal Structure of E18D DJ-1 分子名称: MALONIC ACID, Protein DJ-1 著者 Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hashim, S, Pozharski, E, Wilson, M.A. 登録日 2008-04-28 公開日 2008-07-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Cysteine pKa depression by a protonated glutamic acid in human DJ-1. Biochemistry, 47, 2008
8CZ2	CryoEM structure of amplified alpha-synuclein fibril class A type I with extended core from DLB case VII 分子名称: Alpha-synuclein 著者 Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A. 登録日 2022-05-24 公開日 2023-05-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid To Be Published
8CZ6	CryoEM structure of amplified alpha-synuclein fibril class A type I with extended core from DLB case X 分子名称: Alpha-synuclein 著者 Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A. 登録日 2022-05-24 公開日 2023-05-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid To Be Published
3TEI	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 著者 Gogl, G, Remenyi, A. 登録日 2011-08-15 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.404 Å) 主引用文献 Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012

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