PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5L9X	Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 60s 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... 著者 Gao, Y, Yang, W. 登録日 2016-06-12 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016
8GD7	Loop Deleted DNA Polymerase Theta Polymerase Domain in Complex with Double Strand DNA Overhang and Inhibitor 分子名称: 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-(3-methyl-2-oxoimidazolidin-1-yl)-4,6-bis(trifluoromethyl)phenyl (4-fluorophenyl)methylcarbamate, DNA Primer, ... 著者 Fried, W.A, Chen, X.S, Li, S.X. 登録日 2023-03-03 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Discovery of a small-molecule inhibitor that traps Pol theta on DNA and synergizes with PARP inhibitors. Nat Commun, 15, 2024
6OD9	Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser 分子名称: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, CESIUM ION, MAGNESIUM ION, ... 著者 Jones, C.P, Tran, B, Ferre-D'Amare, A.R. 登録日 2019-03-26 公開日 2019-07-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.102 Å) 主引用文献 Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser. Acta Crystallogr.,Sect.F, 75, 2019
6ECL	Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase 分子名称: 1-[4-methoxy-3-[[5-methyl-4-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]phenyl]ethanone, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H 著者 Kirby, K.A, Sarafianos, S.G. 登録日 2018-08-08 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.385 Å) 主引用文献 Crystal Structure of a 1,2,4-Triazole Allosteric RNase H Inhibitor in Complex with HIV Reverse Transcriptase To be published
4LIK	Crystal structure of the catalytic subunit of human primase 分子名称: CITRIC ACID, DNA primase small subunit, ZINC ION 著者 Vaithiyalingam, S, Eichman, B.F, Chazin, W.J. 登録日 2013-07-02 公開日 2013-12-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase. J.Mol.Biol., 426, 2014
4LIL	Crystal structure of the catalytic subunit of human primase bound to UTP and Mn 分子名称: DNA primase small subunit, MANGANESE (II) ION, URIDINE 5'-TRIPHOSPHATE, ... 著者 Vaithiyalingam, S, Eichman, B.F, Chazin, W.J. 登録日 2013-07-02 公開日 2013-12-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase. J.Mol.Biol., 426, 2014
6USR	Telomerase Reverse Transcriptase ternary complex, TERT:DNA:dGpCpp 分子名称: DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ... 著者 Schaich, M.A, Freudenthal, B.D. 登録日 2019-10-28 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Mechanisms of nucleotide selection by telomerase. Elife, 9, 2020
6USJ	Structure of two nucleosomes bridged by human PARP2 分子名称: Histone H2A, Histone H2B type 1-J, Histone H3.1, ... 著者 Gaullier, G, Bowerman, S, Luger, K. 登録日 2019-10-27 公開日 2020-10-14 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (10.5 Å) 主引用文献 Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1. Plos One, 15, 2020
1JFI	Crystal Structure of the NC2-TBP-DNA Ternary Complex 分子名称: 5'-D(*G*GP*AP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*AP*A)-3', 5'-D(*TP*TP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*TP*CP*C)-3', TATA-BOX-BINDING PROTEIN (TBP), ... 著者 Kamada, K, Shu, F, Chen, H, Malik, S, Stelzer, G, Roeder, R.G, Meisterernst, M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2001-06-20 公開日 2001-07-11 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex. Cell(Cambridge,Mass.), 106, 2001
8DHN	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one 分子名称: (2P)-6-bromo-3-hydroxy-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridin-4(1H)-one, MANGANESE (II) ION, PA endonuclease 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-27 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
6NE8	Solution Structure of the Thioredoxin-like Domain of Arabidopsis NCP (NUCLEAR CONTROL OF PEP ACTIVITY) 分子名称: Thioredoxin-like fold domain-containing protein MRL7L, chloroplastic 著者 Liu, J, Chen, M, Zhou, P. 登録日 2018-12-17 公開日 2019-12-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. Nat Commun, 10, 2019
4F7P	Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009H1N1 PB1 (496-505) 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... 著者 Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, Gao, G.F. 登録日 2012-05-16 公開日 2012-10-10 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. J.Virol., 86, 2012
3BBZ	Structure of the nucleocapsid-binding domain from the mumps virus phosphoprotein 分子名称: BROMIDE ION, FORMIC ACID, P protein 著者 Kingston, R.L, Gay, L.S, Baase, W.S, Matthews, B.W. 登録日 2007-11-11 公開日 2008-05-27 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the nucleocapsid-binding domain from the mumps virus polymerase; an example of protein folding induced by crystallization J.Mol.Biol., 379, 2008
6EHT	Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme 分子名称: DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), PCNA-associated factor, ... 著者 De March, M, Barrera-Vilarmau, S, Mentegari, E, Merino, N, Bressan, E, Maga, G, Crehuet, R, Onesti, S, Blanco, F.J, De Biasio, A. 登録日 2017-09-15 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 p15PAF binding to PCNA modulates the DNA sliding surface. Nucleic Acids Res., 46, 2018
5MHQ	CCT068127 in complex with CDK2 分子名称: (2~{R},3~{S})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol, Cyclin-dependent kinase 2 著者 Whittaker, S.R, Barlow, C, Martin, M.P, Mancusi, C, Wagner, S, Barrie, E, te Poele, R, Sharp, S, Brown, N, Wilson, S, Clarke, P, Walton, M.I, MacDonald, E, Blagg, J, Noble, M.E.M, Garrett, M.D, Workman, P. 登録日 2016-11-25 公開日 2017-12-20 最終更新日 2018-03-14 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. Mol Oncol, 12, 2018
6LBE	Crystal structure of bony fish MHC class I binding beta2M-2 for 2.6 angstrom 分子名称: 9-mer peptide from RNA-DIRECTED RNA POLYMERASE L, Beta-2-microglobulin, MHC class I antigen 著者 Li, Z.B, Xia, C. 登録日 2019-11-14 公開日 2020-11-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The Mechanism of beta 2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish. Iscience, 23, 2020
8PEM	Zika Methyltransferase in complex with AT-9010 and SAH 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Krejcova, K, Boura, E, Klima, M. 登録日 2023-06-14 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Zika Methyltransferase in complex with AT-9010 and SAH to be published
6E1A	Menin bound to M-89 分子名称: (1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, Menin, praseodymium triacetate 著者 Stuckey, J.A. 登録日 2018-07-09 公開日 2019-07-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J.Med.Chem., 62, 2019
1UET	Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure 分子名称: ACETATE ION, CALCIUM ION, MAGNESIUM ION, ... 著者 Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-05-21 公開日 2003-12-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. Embo J., 22, 2003
6T9J	SAGA Tra1 module 分子名称: Transcription factor SPT20, Transcription initiation factor TFIID subunit 12, Transcription-associated protein 1 著者 Wang, H, Cheung, A, Cramer, P. 登録日 2019-10-28 公開日 2020-01-29 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of the transcription coactivator SAGA. Nature, 577, 2020
1UEU	Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure 分子名称: ACETATE ION, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Nureki, O, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2003-05-21 公開日 2003-12-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. Embo J., 22, 2003
5E8B	Crystal structure of the S. cerevisiae Rtf1 histone modification domain mutant R126A 分子名称: BENZAMIDINE, RNA polymerase-associated protein RTF1, SODIUM ION 著者 Wier, A.D, Heroux, A, VanDemark, A.P. 登録日 2015-10-14 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6. Mol. Cell, 64, 2016
8J9A	Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2 分子名称: Mediator of RNA polymerase II transcription subunit 15 著者 Zhang, H, Li, Y. 登録日 2023-05-03 公開日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2 To Be Published
4P9A	X-ray Crystal Structure of PA protein from Influenza strain H7N9 分子名称: GLYCEROL, Polymerase PA 著者 Fairman, J.W, Moen, S.O, Clifton, M.C, Edwards, T.E, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2014-04-02 公開日 2014-07-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1999 Å) 主引用文献 Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1. Sci Rep, 4, 2014
1I4W	THE CRYSTAL STRUCTURE OF THE TRANSCRIPTION FACTOR SC-MTTFB OFFERS INTRIGUING INSIGHTS INTO MITOCHONDRIAL TRANSCRIPTION 分子名称: MITOCHONDRIAL REPLICATION PROTEIN MTF1, XENON 著者 Schubot, F.D, Chen, C.-J, Rose, J.P, Dailey, T.A, Dailey, H.A, Wang, B.-C. 登録日 2001-02-23 公開日 2001-10-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci., 10, 2001

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