4X36
 
 | | Crystal structure of the autolysin LytA from Streptococcus pneumoniae TIGR4 | | 分子名称: | Autolysin, CHOLINE ION, GLYCEROL, ... | | 著者 | Cheng, W, Li, Q, Zhou, C.Z, Chen, Y.X. | | 登録日 | 2014-11-28 | | 公開日 | 2015-05-27 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | Full-length structure of the major autolysin LytA.
Acta Crystallogr.,Sect.D, 71, 2015
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4NMM
 | | Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor | | 分子名称: | 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION | | 著者 | Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D. | | 登録日 | 2013-11-15 | | 公開日 | 2014-06-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Proc.Natl.Acad.Sci.USA, 111, 2014
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6LC5
 | | Crystal structure of barley exohydrolaseI W434F in complex with 4'-nitrophenyl thiolaminaribioside | | 分子名称: | (2~{R},3~{S},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-4-[(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanyl-oxane-2,3,5-triol, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ... | | 著者 | Luang, S, Streltsov, V.A, Hrmova, M. | | 登録日 | 2019-11-17 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases.
Nat Commun, 13, 2022
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5VQN
 | | E119D mutant of 2009 H1N1 PA Endonuclease in complex with RO-7 | | 分子名称: | 1-[(11S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-5-hydroxy-3-[(2R)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione, MANGANESE (II) ION, Polymerase acidic protein, ... | | 著者 | Kumar, G, White, S.W. | | 登録日 | 2017-05-09 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.
MBio, 9, 2018
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7CP0
 | | Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase | | 分子名称: | 1,2-ETHANEDIOL, Glutaminyl-peptide cyclotransferase, SULFATE ION, ... | | 著者 | Dileep, K.V, Ihara, K, Sakai, N, Shirozu, M, Zhang, K.Y.J. | | 登録日 | 2020-08-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.
Int.J.Biol.Macromol., 170, 2020
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5TS0
 | | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2208 | | 分子名称: | (2S)-N-{(2S)-3-methoxy-1-[(naphthalen-1-ylmethyl)amino]-1-oxopropan-2-yl}-4-oxo-2-[(3-phenylpropanoyl)amino]-4-(1H-pyrrol-1-yl)butanamide (non-preferred name), Proteasome subunit alpha, Proteasome subunit beta | | 著者 | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | | 登録日 | 2016-10-27 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.84679747 Å) | | 主引用文献 | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.
Biochemistry, 56, 2017
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2W93
 | | Crystal structure of the Saccharomyces cerevisiae pyruvate decarboxylase variant E477Q in complex with the surrogate pyruvamide | | 分子名称: | (1S,2S)-1-amino-1,2-dihydroxypropan-1-olate, MAGNESIUM ION, PYRUVATE DECARBOXYLASE ISOZYME 1, ... | | 著者 | Kutter, S, Weiss, M.S, Konig, S. | | 登録日 | 2009-01-21 | | 公開日 | 2009-02-03 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Allosteric Activation of Pyruvate Decarboxylases. A Never-Ending Story.
J.Mol.Catal., B Enzym., 61, 2014
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4NT0
 | | Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate | | 分子名称: | 4-hydroxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-2(1H)-one, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Fedorov, A.A, Fedorov, E.V, Iiams, V, Gerlt, J.A, Almo, S.C. | | 登録日 | 2013-11-29 | | 公開日 | 2013-12-18 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.769 Å) | | 主引用文献 | Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate
To be Published
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5TRS
 | | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2144 | | 分子名称: | N-tert-butoxy-N~2~-(5-methyl-1,2-oxazole-3-carbonyl)-L-asparaginyl-O-methyl-N-[(naphthalen-1-yl)methyl]-L-serinamide, Proteasome subunit alpha, Proteasome subunit beta | | 著者 | Hsu, H.-C, Fan, H, Singh, P.K, Wang, R, Sukenick, G, Nathan, C, Lin, G, Li, H. | | 登録日 | 2016-10-27 | | 公開日 | 2017-01-11 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.083567 Å) | | 主引用文献 | Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.
Biochemistry, 56, 2017
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4YKR
 | | Heat Shock Protein 90 Bound to CS302 | | 分子名称: | 1-(2,4-dihydroxy-5-propylphenyl)-1,3-dihydro-2H-benzimidazol-2-one, GLYCEROL, Heat shock protein HSP 90-alpha | | 著者 | Kang, Y.N, Stuckey, J.A. | | 登録日 | 2015-03-04 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Structure of Heat Shock Protein 90 Bound to CS302
To Be Published
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6R1L
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9JHY
 | | 3-Hydroxybutyryl-CoA dehydrogenase mutant (S117A) with acetoacetyl CoA | | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein, ACETOACETYL-COENZYME A | | 著者 | Yang, J.W, Jeon, H.J, Park, S.H, Jang, S.H, Park, J.A, Kim, S.H, Hwang, K.Y. | | 登録日 | 2024-09-10 | | 公開日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Insights and Catalytic Mechanism of 3-Hydroxybutyryl-CoA Dehydrogenase from Faecalibacterium Prausnitzii A2-165.
Int J Mol Sci, 25, 2024
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6ANP
 | | CAT192 Fab Insertion Mutant H5/L0 | | 分子名称: | CAT192 Fab Heavy chain, CAT192 Fab Light chain | | 著者 | Lord, D.M, Wei, R.R. | | 登録日 | 2017-08-14 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
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9JHE
 | | 3-hydroxybutyryl-CoA dehydrogenase with NAD | | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Park, J.A, Yang, J.W, Park, S.H, Kim, S.H, Hwang, K.Y. | | 登録日 | 2024-09-09 | | 公開日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural Insights and Catalytic Mechanism of 3-Hydroxybutyryl-CoA Dehydrogenase from Faecalibacterium Prausnitzii A2-165.
Int J Mol Sci, 25, 2024
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7F5H
 | | The crystal structure of RBD-Nanobody complex, DL28 (SC4) | | 分子名称: | GLYCEROL, Nanobody DL28, PHOSPHATE ION, ... | | 著者 | Luo, Z.P, Li, T, Lai, Y, Zhou, Y, Tan, J, Li, D. | | 登録日 | 2021-06-22 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants.
Front Microbiol, 13, 2022
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5JNV
 | | Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, Low molecular weight phosphotyrosine protein phosphatase | | 著者 | Stanford, S.M, Aleshin, A.E, Liddington, R.C, Bankston, L, Cadwell, G, Bottini, N. | | 登録日 | 2016-04-30 | | 公開日 | 2017-03-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Nat. Chem. Biol., 13, 2017
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3ITB
 | | Crystal structure of Penicillin-Binding Protein 6 (PBP6) from E. coli in complex with a substrate fragment | | 分子名称: | D-alanyl-D-alanine carboxypeptidase DacC, Peptidoglycan substrate (AMV)A(FGA)K(DAL)(DAL), SULFATE ION, ... | | 著者 | Chen, Y, Zhang, W, Shi, Q, Hesek, D, Lee, M, Mobashery, S, Shoichet, B.K. | | 登録日 | 2009-08-27 | | 公開日 | 2009-10-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of penicillin-binding protein 6 from Escherichia coli.
J.Am.Chem.Soc., 131, 2009
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5AHT
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6F00
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8S6S
 | | Oxidoreductase from Phytophthora sojae | | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | | 著者 | Banerjee, S, Turella, S, Morth, J.P, Abou Hachem, M. | | 登録日 | 2024-02-28 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-05-14 | | 実験手法 | X-RAY DIFFRACTION (1.789 Å) | | 主引用文献 | Enzymatic oxidation of galacturonides from pectin breakdown contributes to stealth infection by Oomycota phytopathogens.
Nat Commun, 16, 2025
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4YVG
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4ACZ
 | | Structure of the GH99 endo-alpha-mannosidase from Bacteroides thetaiotaomicron | | 分子名称: | ENDO-ALPHA-MANNOSIDASE, GLYCEROL | | 著者 | Thompson, A.J, Williams, R.J, Hakki, Z, Alonzi, D.S, Wennekes, T, Gloster, T.M, Songsrirote, K, Thomas-Oates, J.E, Wrodnigg, T.M, Spreitz, J, Stuetz, A.E, Butters, T.D, Williams, S.J, Davies, G.J. | | 登録日 | 2011-12-21 | | 公開日 | 2012-02-01 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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9J4X
 | | CryoEM structure of human XPR1 in apo state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Solute carrier family 53 member 1 | | 著者 | Zhang, W.H, Chen, Y.K, Guan, Z.Y, Liu, Z. | | 登録日 | 2024-08-10 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-07-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into the mechanism of phosphate recognition and transport by XPR1.
Nat Commun, 16, 2025
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5A4J
 | | Crystal structure of FTHFS1 from T.acetoxydans Re1 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, D(-)-TARTARIC ACID, ... | | 著者 | Bergdahl, R, Jacobson, F, Muller, B, Mikkelsen, N, Schurer, A, Sandgren, M. | | 登録日 | 2015-06-10 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Characterization, Crystallization and Three- Dimensional Structures of Formyltetrahydrofolate Synthetase (Fthfs) from the Syntrophic Acetate Oxidising Bacterium Tepidanaerobacter Acetatoxydans Re1
To be Published
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9J61
 | | Crystal structure of a cyclodipeptide synthase from Streptomyces sapporonensis | | 分子名称: | 1,2-ETHANEDIOL, Cyclodipeptide synthase, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Li, P, Ren, Y, He, J, Wu, S, Wang, J, Tang, G, Fang, P. | | 登録日 | 2024-08-14 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure and Mutagenesis of an XYP Subfamily Cyclodipeptide Synthase Reveal Key Determinants of Enzyme Activity and Substrate Specificity.
Biochemistry, 63, 2024
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