PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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6Y7Y	Fragments KCL_771 and KCL_802 in complex with MAP kinase p38-alpha 分子名称: (2-azanyl-2-adamantyl)methanol, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridine-3-sulfonamide, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-02 公開日 2020-03-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5JHT	Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region crystallized with potassium sodium tartrate 分子名称: L(+)-TARTARIC ACID, MANGANESE (II) ION, Polymerase acidic protein 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. 登録日 2016-04-21 公開日 2016-05-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.751 Å) 主引用文献 Influence of Precipitants on Molecular Arrangements and Space Groups of Protein Crystals Cryst.Growth Des., 17, 2017
6Y81	Fragment KCL_1088 in complex with MAP kinase p38-alpha 分子名称: (3~{R})-~{N}-[(2-azanyl-2-adamantyl)methyl]-3-[[6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridin-3-yl]sulfonylamino]-3-phenyl-propanamide, 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-03 公開日 2020-03-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
6Y80	Fragment KCL_916 in complex with MAP kinase p38-alpha 分子名称: 1-(2-adamantylmethyl)-3-ethyl-guanidine, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-02 公開日 2020-03-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
6FS8	Influenza B/Memphis/13/03 endonuclease with bound inhibitor, baloxavir acid (BXA) 分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein 著者 Cusack, S, Speranzini, V. 登録日 2018-02-19 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep, 8, 2018
6YCW	Fragment KCL_K767 in complex with MAP kinase p38-alpha 分子名称: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, Mitogen-activated protein kinase 14, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-19 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
6Y7X	Fragment KCL_771 in complex with MAP kinase p38-alpha 分子名称: (2-azanyl-2-adamantyl)methanol, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ... 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-02 公開日 2020-03-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5JHV	Apo form of influenza strain H1N1 polymerase acidic subunit N-terminal region crystallized with polyethylene glycol 8000 分子名称: MANGANESE (II) ION, Polymerase acidic protein 著者 Fudo, S, Yamamoto, N, Nukaga, M, Odagiri, T, Tashiro, M, Hoshino, T. 登録日 2016-04-21 公開日 2016-05-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.749 Å) 主引用文献 Influence of Precipitants on Molecular Arrangements and Space Groups of Protein Crystals Cryst.Growth Des., 17, 2017
7XGC	Crystal structure of influenza polymerase acidic subunit N-terminal domain crystallized by ammonium sulfate with glycan 分子名称: MANGANESE (II) ION, Polymerase acidic protein, SULFATE ION 著者 Guo, Y, Hoshino, T. 登録日 2022-04-04 公開日 2022-04-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Influence of Glycan Agents on Protein Crystallization with Ammonium Sulfate Cryst.Growth Des., 2022
6BC8	Crystal structure of Rev7-R124A/Rev3-RBM2 (residues 1988-2014) complex 分子名称: ACETATE ION, DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B, ... 著者 Rizzo, A.A, Hao, B, Li, Y, Korzhnev, D.M. 登録日 2017-10-20 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BI7	Crystal structure of Rev7-WT/Rev3 as a monomer under high-salt conditions 分子名称: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B 著者 Rizzo, A.A, Korzhnev, D.M, Hao, B, Li, Y. 登録日 2017-11-01 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4H5Q	Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Hexamer Bound to Single-stranded DNA 分子名称: 30-mer poly(T) DNA, Nucleocapsid protein 著者 Raymond, D.D, Smith, J.L. 登録日 2012-09-18 公開日 2012-11-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc.Natl.Acad.Sci.USA, 109, 2012
4M5U	5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease 分子名称: 5-(4-fluorophenyl)-3-hydroxy-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one, MANGANESE (II) ION, Polymerase PA, ... 著者 Bauman, J.D, Patel, D, Das, K, Arnold, E. 登録日 2013-08-08 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease. Bioorg.Med.Chem., 21, 2013
4H5L	Crystal Structure of Toscana Virus Nucleocapsid Protein Hexamer 分子名称: Nucleoprotein 著者 Raymond, D.D, Smith, J.L. 登録日 2012-09-18 公開日 2012-11-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc.Natl.Acad.Sci.USA, 109, 2012
7XME	Structure of Influenza A virus polymerase basic protein 2 (PB2) with an azazindole derivative 分子名称: (2~{S},3~{S})-3-[[5-dimethoxyphosphoryl-4-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, IODIDE ION, Polymerase basic protein 2 著者 Zhang, Z. 登録日 2022-04-25 公開日 2023-05-03 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.521 Å) 主引用文献 Discovery of a novel azaindole derivatives targeting the influenza PB2 cap binding region To Be Published
6BCD	Crystal structure of Rev7-K44A/R124A/A135D in complex with Rev3-RBM2 (residues 1988-2014) 分子名称: DNA polymerase zeta catalytic subunit, Mitotic spindle assembly checkpoint protein MAD2B 著者 Rizzo, A.A, Hao, B, Li, Y, Korzhnev, D.M. 登録日 2017-10-20 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Rev7 dimerization is important for assembly and function of the Rev1/Pol zeta translesion synthesis complex. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4H5M	Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Hexamer 分子名称: Nucleocapsid protein, SULFATE ION 著者 Raymond, D.D, Smith, J.L. 登録日 2012-09-18 公開日 2012-11-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Phleboviruses encapsidate their genomes by sequestering RNA bases. Proc.Natl.Acad.Sci.USA, 109, 2012
7PRD	Solution structure of the chimeric Nrd1-Nab3 heterodimerization domains 分子名称: Protein NRD1,HLJ1_G0022400.mRNA.1.CDS.1 著者 Chaves-Arquero, B, Martinez-Lumbreras, S, Perez-Canadillas, J.M. 登録日 2021-09-21 公開日 2022-01-12 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural basis of Nrd1-Nab3 heterodimerization. Life Sci Alliance, 5, 2022
6NZ2	NMR solution structure of Bcd1p120-303 from Saccharomyces cerevisiae 分子名称: Box C/D snoRNA protein 1 著者 Bragantini, B, Quinternet, M, Charpentier, B, Manival, X. 登録日 2019-02-12 公開日 2020-08-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity. Nat Commun, 12, 2021
7E4W	Human Transcriptional Co-activator PC4 (C-terminal Domain) in space group P1211 分子名称: Activated RNA polymerase II transcriptional coactivator p15 著者 Dev, A, Pandey, B, Basu, G. 登録日 2021-02-15 公開日 2021-09-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Biochem.Biophys.Res.Commun., 578, 2021
7UMK	Structure of vesicular stomatitis virus (helical reconstruction, 4.1 A resolution) 分子名称: Matrix protein, Nucleoprotein, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 著者 Jenni, S, Horwitz, J.A, Bloyet, L.-M, Whelan, S.P.J, Harrison, S.C. 登録日 2022-04-07 公開日 2022-04-20 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle. Nat Commun, 13, 2022
4HXD	Diversity of ubiquitin and ISG15 specificity amongst nairoviruses viral ovarian tumor domain proteases 分子名称: 1.7.6 3-bromanylpropan-1-amine, Polyubiquitin-C, RNA-directed RNA polymerase L, ... 著者 Capodagli, G.C, Pegan, S.D. 登録日 2012-11-09 公開日 2013-02-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Diversity of Ubiquitin and ISG15 Specificity among Nairoviruses' Viral Ovarian Tumor Domain Proteases. J.Virol., 87, 2013
5XE7	Crystal structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigJ 分子名称: ECF RNA polymerase sigma factor SigJ 著者 Goutam, K, Gopal, B. 登録日 2017-04-01 公開日 2017-07-19 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (2.162 Å) 主引用文献 The fused SnoaL_2 domain in the Mycobacterium tuberculosis sigma factor sigma J modulates promoter recognition Nucleic Acids Res., 45, 2017
6ONO	Complex structure of WhiB1 and region 4 of SigA in C2221 space group 分子名称: DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, RNA polymerase sigma factor SigA, ... 著者 Wan, T, Li, S.R, Beltran, D.G, Schacht, A, Becker, D.C, Zhang, L.M. 登録日 2019-04-22 公開日 2019-11-27 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural basis of non-canonical transcriptional regulation by the sigma A-bound iron-sulfur protein WhiB1 in M. tuberculosis. Nucleic Acids Res., 48, 2020
4UN0	Crystal structure of the human CDK12-cyclinK complex 分子名称: CYCLIN-DEPENDENT KINASE 12, CYCLIN-K 著者 Dixon Clarke, S.E, Elkins, J.M, Pike, A.C.W, Chaikuad, A, Goubin, S, Krojer, T, Sorrell, F.J, Nowak, R, Williams, E, Kopec, J, Mahajan, R.P, Burgess-Brown, N, Carpenter, E.P, Knapp, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A. 登録日 2014-05-22 公開日 2014-06-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding. Sci.Rep., 5, 2015

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