7XME

Structure of Influenza A virus polymerase basic protein 2 (PB2) with an azazindole derivative

Summary for 7XME

• Entry DOI: 10.2210/pdb7xme/pdb
• Descriptor: Polymerase basic protein 2, IODIDE ION, (2~{S},3~{S})-3-[[5-dimethoxyphosphoryl-4-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, rna binding protein
• Biological source: Influenza A virus (A/Victoria/3/1975(H3N2))
• Total number of polymer chains: 4
• Total formula weight: 77969.13

Authors

Zhang, Z. (deposition date: 2022-04-25, release date: 2023-05-03, Last modification date: 2023-11-29)

• Primary citation: Zhang, Z.,Liu, X.; Discovery of a novel azaindole derivatives targeting the influenza PB2 cap binding region; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.521 Å)