6QKZ
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![BU of 6qkz by Molmil](/molmil-images/mine/6qkz) | Full length GluA1/2-gamma8 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, ... | 著者 | Herguedas, B, Garcia-Nafria, J, Greger, I.G. | 登録日 | 2019-01-30 | 公開日 | 2019-03-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8. Science, 364, 2019
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8AGH
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![BU of 8agh by Molmil](/molmil-images/mine/8agh) | BK Polyomavirus VP1 mutant E73A | 分子名称: | CHLORIDE ION, GLYCEROL, Major capsid protein VP1 | 著者 | Sorin, M.N, Di Maio, A, Silva, L.M, Ebert, D, Delannoy, C, Nguyen, N.-K, Guerardel, Y, Chai, W, Halary, F, Renaudin-Autain, K, Liu, Y, Bressollette-Bodin, C, Stehle, T, McIlroy, D. | 登録日 | 2022-07-20 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.887 Å) | 主引用文献 | Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus. Cell Rep, 42, 2023
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8AGO
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![BU of 8ago by Molmil](/molmil-images/mine/8ago) | BK Polyomavirus VP1 mutant E73Q | 分子名称: | CHLORIDE ION, GLYCEROL, Major capsid protein VP1 | 著者 | Sorin, M.N, Di Maio, A, Silva, L.M, Ebert, D, Delannoy, C, Nguyen, N.-K, Guerardel, Y, Chai, W, Halary, F, Renaudin-Autain, K, Liu, Y, Bressollette-Bodin, C, Stehle, T, McIlroy, D. | 登録日 | 2022-07-20 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus. Cell Rep, 42, 2023
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8AH0
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![BU of 8ah0 by Molmil](/molmil-images/mine/8ah0) | BK Polyomavirus VP1 mutant VQQ | 分子名称: | CHLORIDE ION, GLYCEROL, Major capsid protein VP1 | 著者 | Sorin, M.N, Di Maio, A, Silva, L.M, Ebert, D, Delannoy, C, Nguyen, N.-K, Guerardel, Y, Chai, W, Halary, F, Renaudin-Autain, K, Liu, Y, Bressollette-Bodin, C, Stehle, T, McIlroy, D. | 登録日 | 2022-07-20 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus. Cell Rep, 42, 2023
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8AH1
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![BU of 8ah1 by Molmil](/molmil-images/mine/8ah1) | BK Polyomavirus VP1 mutant N-Q | 分子名称: | CHLORIDE ION, GLYCEROL, Major capsid protein VP1 | 著者 | Sorin, M.N, Di Maio, A, Silva, L.M, Ebert, D, Delannoy, C, Nguyen, N.-K, Guerardel, Y, Chai, W, Halary, F, Renaudin-Autain, K, Liu, Y, Bressollette-Bodin, C, Stehle, T, McIlroy, D. | 登録日 | 2022-07-20 | 公開日 | 2023-02-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | Structural and functional analysis of natural capsid variants suggests sialic acid-independent entry of BK polyomavirus. Cell Rep, 42, 2023
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8FU3
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![BU of 8fu3 by Molmil](/molmil-images/mine/8fu3) | Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor | 分子名称: | 8-methoxy-3-methyl-N-{(2S)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide, Phosphoprotein, RNA-directed RNA polymerase L | 著者 | Yu, X, Abeywickrema, P, Bonneux, B, Behera, I, Jacoby, E, Fung, A, Adhikary, S, Bhaumik, A, Carbajo, R.J, Bruyn, S.D, Miller, R, Patrick, A, Pham, Q, Piassek, M, Verheyen, N, Shareef, A, Sutto-Ortiz, P, Ysebaert, N, Vlijmen, H.V, Jonckers, T.H.M, Herschke, F, McLellan, J.S, Decroly, E, Fearns, R, Grosse, S, Roymans, D, Sharma, S, Rigaux, P, Jin, Z. | 登録日 | 2023-01-16 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor. Commun Biol, 6, 2023
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5HUO
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8WY3
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![BU of 8wy3 by Molmil](/molmil-images/mine/8wy3) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 21 | 分子名称: | Bromodomain-containing protein 4, ~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide | 著者 | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | 登録日 | 2023-10-30 | 公開日 | 2024-01-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8WYG
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![BU of 8wyg by Molmil](/molmil-images/mine/8wyg) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor 22 | 分子名称: | 2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide, Bromodomain-containing protein 2 | 著者 | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | 登録日 | 2023-10-30 | 公開日 | 2024-01-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8RPO
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![BU of 8rpo by Molmil](/molmil-images/mine/8rpo) | BFL1 in complex with a reversible covalent ligand | 分子名称: | (~{E})-2-cyano-3-(2-dimethylphosphorylphenyl)-~{N}-[[1-[4-(trifluoromethyl)phenyl]cyclopropyl]methyl]prop-2-enamide, Bcl-2-related protein A1 | 著者 | Hargreaves, D. | 登録日 | 2024-01-16 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.791 Å) | 主引用文献 | Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen. Acs Med.Chem.Lett., 15, 2024
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6QU8
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![BU of 6qu8 by Molmil](/molmil-images/mine/6qu8) | Adenovirus Serotype 26 (Ad26) in complex with sialic acid, pH8.0 | 分子名称: | 1,2-ETHANEDIOL, Fiber, N-acetyl-alpha-neuraminic acid, ... | 著者 | Baker, A.T, Rizkallah, P.J, Parker, A.L, Mundy, R.M. | 登録日 | 2019-02-26 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor. Sci Adv, 5, 2019
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2BEX
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![BU of 2bex by Molmil](/molmil-images/mine/2bex) | Crystal structure of Placental Ribonuclease Inhibitor in complex with Human Eosinophil Derived Neurotoxin at 2A resolution | 分子名称: | ALPHA-KETOMALONIC ACID, GLYCEROL, NONSECRETORY RIBONUCLEASE, ... | 著者 | Iyer, S, Holloway, D.E, Kumar, K, Shapiro, R, Acharya, K.R. | 登録日 | 2004-12-01 | 公開日 | 2005-03-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Molecular Recognition of Human Eosinophil-Derived Neurotoxin (Rnase 2) by Placental Ribonuclease Inhibitor J.Mol.Biol., 347, 2005
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5HUH
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![BU of 5huh by Molmil](/molmil-images/mine/5huh) | Crystal Structure of NadE from Streptococcus pyogenes | 分子名称: | MAGNESIUM ION, NH(3)-dependent NAD(+) synthetase, SULFATE ION | 著者 | Booth, W.T, Chruszcz, M. | 登録日 | 2016-01-27 | 公開日 | 2017-01-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3 -dependent NAD(+) synthetase. FEBS J., 284, 2017
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5ZB6
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6QU6
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![BU of 6qu6 by Molmil](/molmil-images/mine/6qu6) | Adenovirus Serotype 26 (Ad26) in complex with sialic acid, pH4.0 | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fiber, ... | 著者 | Baker, A.T, Mundy, R.M, Parker, A.L, Rizkallah, P.J. | 登録日 | 2019-02-26 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor. Sci Adv, 5, 2019
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8X0X
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![BU of 8x0x by Molmil](/molmil-images/mine/8x0x) | Crystal structure of JE-5C in complex with SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of JE-5C Fab, Light chain of JE-5C Fab, ... | 著者 | Mohapatra, A, Chen, X. | 登録日 | 2023-11-06 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine. Plos Pathog., 20, 2024
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8X0Y
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![BU of 8x0y by Molmil](/molmil-images/mine/8x0y) | Crystal structure of JM-1A in complex with SARS-CoV-2 RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Heavy chain of JM-1A Fab, ... | 著者 | Mohapatra, A, Chen, X. | 登録日 | 2023-11-06 | 公開日 | 2024-06-05 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine. Plos Pathog., 20, 2024
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8ASA
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![BU of 8asa by Molmil](/molmil-images/mine/8asa) | Crystal structure of AO75L | 分子名称: | 1,2-ETHANEDIOL, BICINE, CALCIUM ION, ... | 著者 | Laugeri, M.E, Speciale, I, Gimeno, A, Lin, S, Poveda, A, Lowary, T, Van Etten, J.L, Barbero, J.J, De Castro, C, Tonetti, M, Rojas, A.L. | 登録日 | 2022-08-18 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of AO75L To Be Published
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5FHR
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8T55
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![BU of 8t55 by Molmil](/molmil-images/mine/8t55) | Co-crystal structure of the WD-repeat domain of human WDR91 in complex with MR46654 | 分子名称: | 1,2-ETHANEDIOL, N-[3-(4-chlorophenyl)oxetan-3-yl]-1-propanoyl-1,2,3,4-tetrahydroquinoline-5-carboxamide, WD repeat-containing protein 91 | 著者 | Ahmad, H, Zeng, H, Dong, A, Li, Y, Yen, H, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Santhakumar, V, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2023-06-12 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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6A9C
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8V7I
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8V7A
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8V7C
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8SHJ
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![BU of 8shj by Molmil](/molmil-images/mine/8shj) | Crystal structure of the WD-repeat domain of human WDR91 in complex with MR45279 | 分子名称: | N-[3-(4-chlorophenyl)oxetan-3-yl]-4-[(3S)-3-hydroxypyrrolidin-1-yl]benzamide, WD repeat-containing protein 91 | 著者 | Ahmad, H, Zeng, H, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Xu, J, Feng, J.W, Brown, P.J, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2023-04-14 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J.Med.Chem., 66, 2023
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