PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

---

5SXM	WDR5 in complex with MLL Win motif peptidomimetic 分子名称: ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2, WD repeat-containing protein 5 著者 Alicea-Velazquez, N.L, Shinsky, S.A, Cosgrove, M.S. 登録日 2016-08-09 公開日 2016-09-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. J.Biol.Chem., 291, 2016
6S9W	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 16a 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{H}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2019-07-15 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
3UP0	Nuclear receptor DAF-12 from hookworm Ancylostoma ceylanicum in complex with (25S)-delta7-dafachronic acid 分子名称: (5beta,14beta,17alpha,25S)-3-oxocholest-7-en-26-oic acid, Nuclear receptor coactivator 2, aceDAF-12 著者 Zhi, X, Zhou, X.E, Melcher, K, Motola, D.L, Gelmedin, V, Hawdon, J, Kliewer, S.A, Mangelsdorf, D.J, Xu, H.E. 登録日 2011-11-17 公開日 2011-12-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes. J.Biol.Chem., 287, 2012
6S9X	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 15c 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{H}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2019-07-15 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
2E00	Crystal structure of N392L mutant of yeast bleomycin hydrolase 分子名称: Cysteine proteinase 1 著者 O'Farrell, P.A, Joshua-Tor, L. 登録日 2006-10-01 公開日 2007-11-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure Biochem.J., 401, 2007
3U85	Crystal structure of human menin in complex with MLL1 分子名称: Histone-lysine N-methyltransferase 2A, Menin 著者 Huang, J, Wan, B, Lei, M. 登録日 2011-10-15 公開日 2012-02-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
1FN7	COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN 分子名称: 8-OXOGUANINE DNA GLYCOSYLASE 1, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), ... 著者 Norman, D.P.G, Bruner, S.D, Verdine, G.L. 登録日 2000-08-21 公開日 2001-04-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. J.Am.Chem.Soc., 123, 2001
2E02	Crystal structure of H369L mutant of yeast bleomycin hydrolase 分子名称: Cysteine proteinase 1 著者 O'Farrell, P.A, Joshua-Tor, L. 登録日 2006-10-01 公開日 2007-08-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure Biochem.J., 401, 2007
3WEE	Structure of the full-length yeast Arp7-Arp9 Heterodimer 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Actin-like protein ARP9, Actin-related protein 7, ... 著者 Lobsiger, J, Richmond, T.J. 登録日 2013-07-06 公開日 2014-02-26 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of the full-length yeast Arp7-Arp9 heterodimer. Acta Crystallogr.,Sect.D, 70, 2014
2E03	Crystal structure of NQ67E mutant of yeast bleomycin hydrolase 分子名称: Cysteine proteinase 1 著者 O'Farrell, P.A, Joshua-Tor, L. 登録日 2006-10-01 公開日 2007-08-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure Biochem.J., 401, 2007
2DZZ	Crystal structure of N392V mutant of yeast bleomycin hydrolase 分子名称: Cysteine proteinase 1 著者 O'Farrell, P.A, Joshua-Tor, L. 登録日 2006-09-30 公開日 2007-08-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure Biochem.J., 401, 2007
3U88	Crystal structure of human menin in complex with MLL1 and LEDGF 分子名称: (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol, CHOLIC ACID, GLYOXYLIC ACID, ... 著者 Huang, J, Wan, B, Lei, M. 登録日 2011-10-16 公開日 2012-02-15 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature, 482, 2012
2JUL	NMR Structure of DREAM 分子名称: CALCIUM ION, Calsenilin 著者 Ames, J. 登録日 2007-08-30 公開日 2008-04-22 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR structure of DREAM: Implications for Ca(2+)-dependent DNA binding and protein dimerization. Biochemistry, 47, 2008
1Z91	x-ray crystal structure of apo-OhrRC15S in reduced form: MarR family protein 分子名称: Organic hydroperoxide resistance transcriptional regulator 著者 Hong, M, Fuangthong, M, Helmann, J.D, Brennan, R.G. 登録日 2005-03-31 公開日 2005-10-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of an OhrR-ohrA Operator Complex Reveals the DNA Binding Mechanism of the MarR Family. Mol.Cell, 20, 2005
2DZY	Crystal structure of N392A mutant of yeast bleomycin hydrolase 分子名称: Cysteine proteinase 1 著者 O'Farrell, P.A, Joshua-Tor, L. 登録日 2006-09-30 公開日 2007-08-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure Biochem.J., 401, 2007
2E01	Crystal structure of H369A mutant of yeast bleomycin hydrolase 分子名称: Cysteine proteinase 1 著者 O'Farrell, P.A, Joshua-Tor, L. 登録日 2006-10-01 公開日 2007-08-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure Biochem.J., 401, 2007
2ERK	PHOSPHORYLATED MAP KINASE ERK2 分子名称: EXTRACELLULAR SIGNAL-REGULATED KINASE 2 著者 Canagarajah, B.J, Goldsmith, E.J. 登録日 1997-06-26 公開日 1998-07-01 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell(Cambridge,Mass.), 90, 1997
3BTV	Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S0)-[G301R] 分子名称: Galactose/lactose metabolism regulatory protein GAL80 著者 Kumar, P.R, Joshua-Tor, L. 登録日 2007-12-31 公開日 2008-03-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 NADP regulates the yeast GAL induction system. Science, 319, 2008
5YD8	Crystal structure of human PCNA in complex with APIM of human ZRANB3 分子名称: Proliferating cell nuclear antigen, ZRANB3 著者 Hashimoto, H, Tagata, R. 登録日 2017-09-12 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction. Acta Crystallogr.,Sect.F, 74, 2018
4IEM	Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+ 分子名称: DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*C)-3'), DNA (5'-D(P*(3DR)P*GP*AP*TP*CP*G)-3'), ... 著者 Tsutakawa, S.E, Mol, C.D, Arvai, A.S, Tainer, J.A. 登録日 2012-12-13 公開日 2013-01-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3936 Å) 主引用文献 Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes. J.Biol.Chem., 288, 2013
5YCO	Complex structure of PCNA with UHRF2 分子名称: E3 ubiquitin-protein ligase UHRF2, GLYCEROL, Proliferating cell nuclear antigen, ... 著者 Wu, M, Chen, W, Hang, T, Wang, C, Zhang, X, Zang, J. 登録日 2017-09-07 公開日 2017-11-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA. Biochem. Biophys. Res. Commun., 494, 2017
1EBM	CRYSTAL STRUCTURE OF THE HUMAN 8-OXOGUANINE GLYCOSYLASE (HOGG1) BOUND TO A SUBSTRATE OLIGONUCLEOTIDE 分子名称: 8-OXOGUANINE DNA GLYCOSYLASE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(8OG)P*GP*TP*CP*TP*AP*CP*C)-3'), ... 著者 Bruner, S.D, Norman, D.P, Verdine, G.L. 登録日 2000-01-24 公開日 2000-03-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature, 403, 2000
5NGU	Human Erk2 with an Erk1/2 inhibitor 分子名称: 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-20 公開日 2017-04-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NHH	Human Erk2 with an Erk1/2 inhibitor 分子名称: 5-(2-methoxyethyl)-2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-21 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NHO	Human Erk2 with an Erk1/2 inhibitor 分子名称: (6~{S})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-22 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017

<202203204205206207208209210211212213214215216217>