PDB: 64 件ウェブページステータス検索Chemie searchBIRD

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4RSE	Crystal structure of RPE65 in complex with MB-001 and palmitate 分子名称: (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D, Shi, W, Palczewski, K. 登録日 2014-11-07 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
4F3A	Structure of RPE65: P6522 crystal form, iridium derivative 分子名称: FE (II) ION, IRIDIUM (III) ION, Retinoid isomerohydrolase 著者 Kiser, P.D, Palczewski, K. 登録日 2012-05-09 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA, 109, 2012
4RYY	Crystal structure of RPE65 in complex with R-emixustat and palmitate 分子名称: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D, Palczewski, K. 登録日 2014-12-17 公開日 2015-05-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015
4F30	Structure of RPE65: P6522 crystal form grown in ammonium phosphate solution 分子名称: FE (II) ION, PHOSPHATE ION, Retinoid isomerohydrolase 著者 Kiser, P.D, Palczewski, K. 登録日 2012-05-08 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA, 109, 2012
4RYZ	Crystal structure of RPE65 in complex with S-emixustat and palmitate 分子名称: (1S)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D, Palczewski, K. 登録日 2014-12-17 公開日 2015-05-27 最終更新日 2021-07-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015
4F3D	Structure of RPE65: P65 crystal form grown in Fos-Choline-10 分子名称: 2-ETHOXYETHANOL, FE (II) ION, Retinoid isomerohydrolase 著者 Kiser, P.D, Palczewski, K. 登録日 2012-05-09 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA, 109, 2012
4RSC	Crystal structure of RPE65 in complex with emixustat and palmitate 分子名称: (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D, Shi, W, Palczewski, K. 登録日 2014-11-07 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
4F2Z	Crystal structure of RPE65 in a lipid environment 分子名称: FE (II) ION, Retinoid isomerohydrolase 著者 Kiser, P.D, Shi, W, Palczewski, K. 登録日 2012-05-08 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc.Natl.Acad.Sci.USA, 109, 2012
5KJD	Synechocystis apocarotenoid oxygenase (ACO) mutant - Glu150Gln 分子名称: Apocarotenoid-15,15'-oxygenase, FE (II) ION 著者 Sui, X, Kiser, P.D, Palczewski, K. 登録日 2016-06-18 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J.Biol.Chem., 291, 2016
5KK0	Synechocystis ACO mutant - T136A 分子名称: Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION 著者 Sui, X, Kiser, P.D, Palczewski, K. 登録日 2016-06-20 公開日 2016-07-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J.Biol.Chem., 290, 2015
5KJB	Synechocystis apocarotenoid oxygenase (ACO) mutant - Glu150Asp 分子名称: Apocarotenoid-15,15'-oxygenase, FE (II) ION 著者 Sui, X, Kiser, P.D, Palczewski, K. 登録日 2016-06-18 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J.Biol.Chem., 291, 2016
5KJA	Synechocystis apocarotenoid oxygenase (ACO) mutant - Trp149Ala 分子名称: Apocarotenoid-15,15'-oxygenase, CHLORIDE ION, FE (II) ION 著者 Sui, X, Kiser, P.D, Palczewski, K. 登録日 2016-06-18 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J.Biol.Chem., 291, 2016
7K88	Crystal structure of bovine RPE65 in complex with hexaethylene glycol monooctyl ether 分子名称: 3,6,9,12,15,18-hexaoxahexacosan-1-ol, FE (II) ION, Retinoid isomerohydrolase, ... 著者 Kiser, P.D. 登録日 2020-09-26 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64, 2021
7K8G	Crystal structure of bovine RPE65 in complex with 4-fluoro-MB-004 and palmitate 分子名称: (1R)-3-amino-1-{4-fluoro-3-[(2-propylpentyl)oxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D. 登録日 2020-09-27 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64, 2021
7K89	Crystal structure of bovine RPE65 in complex with 4-fluoro-emixustat and palmitate 分子名称: (1R)-3-amino-1-[3-(cyclohexylmethoxy)-4-fluorophenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D. 登録日 2020-09-26 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64, 2021
7L0E	Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate 分子名称: (1R)-3-amino-1-{3-[(4,4-difluorocyclohexyl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... 著者 Kiser, P.D. 登録日 2020-12-11 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64, 2021
6XM8	Crystal structure of lignostilbene bound to Co-LSD4 from Sphingobium sp. strain SYK-6 分子名称: COBALT (II) ION, DIMETHYL SULFOXIDE, Dioxygenase, ... 著者 Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. 登録日 2020-06-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
6XM9	Crystal structure of vanillin bound to Co-LSD4 from Sphingobium sp. strain SYK-6 分子名称: 4-hydroxy-3-methoxybenzaldehyde, ACETATE ION, COBALT (II) ION, ... 著者 Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. 登録日 2020-06-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.651 Å) 主引用文献 Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
6XMA	Crystal structure of iron-bound LSD4 from Sphingobium sp. strain SYK-6 分子名称: Dioxygenase, FE (III) ION, SULFATE ION 著者 Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. 登録日 2020-06-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
6XM7	Crystal structure of DCA-S bound to Co-LSD4 from Sphingobium sp. strain SYK-6 分子名称: (2E)-3-{4-hydroxy-3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-5-methoxyphenyl}prop-2-enoic acid, COBALT (II) ION, DIMETHYL SULFOXIDE, ... 著者 Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. 登録日 2020-06-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
6XM6	Crystal structure of cobalt-bound LSD4 from Sphingobium sp. strain SYK-6 分子名称: COBALT (II) ION, Dioxygenase 著者 Kuatsjah, E, Chan, A.C, Katahira, R, Beckham, G.T, Murphy, M.E, Eltis, L.D. 登録日 2020-06-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J.Biol.Chem., 296, 2021
6B86	2.2A Crystal Structure of Co-CAO1 分子名称: COBALT (II) ION, Carotenoid oxygenase 1 著者 Hill, H.E, Kiser, P.D. 登録日 2017-10-05 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Preparation and characterization of metal-substituted carotenoid cleavage oxygenases. J. Biol. Inorg. Chem., 23, 2018
6N21	Structure of wild-type CAO1 分子名称: CHLORIDE ION, Carotenoid oxygenase, FE (II) ION 著者 Khadka, N, Kiser, P.D. 登録日 2018-11-12 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J.Biol.Chem., 294, 2019
6N1Y	Structure of L509V CAO1 - growth condition 1 分子名称: CHLORIDE ION, Carotenoid oxygenase, FE (II) ION 著者 Khadka, N, Kiser, P.D. 登録日 2018-11-12 公開日 2019-06-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J.Biol.Chem., 294, 2019
6C7O	Crystal structure of D477G ACO/RPE65 chimera, trigonal crystal form 分子名称: Apocarotenoid-15,15'-oxygenase, FE (II) ION 著者 Kiser, P.D, Shi, W. 登録日 2018-01-23 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum.Mol.Genet., 27, 2018

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