PDB: 91 件ウェブページステータス検索Chemie searchBIRD

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3O0O	Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosylcobalamin 分子名称: 5'-DEOXYADENOSINE, COBALAMIN, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Larsson, K.-M, Logan, D.T, Nordlund, P. 登録日 2010-07-19 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
2XO4	RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI 分子名称: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA 著者 Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J. 登録日 2010-08-09 公開日 2010-08-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. J.Am.Chem.Soc., 133, 2011
2XO5	RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI 分子名称: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA 著者 Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J. 登録日 2010-08-09 公開日 2010-08-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. J.Am.Chem.Soc., 133, 2011
2ZLG	The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase 分子名称: (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1 著者 Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. 登録日 2008-04-09 公開日 2008-08-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
3O0N	Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP and Adenosylcobalamin 分子名称: 5'-DEOXYADENOSINE, CHLORIDE ION, COBALAMIN, ... 著者 Larsson, K.-M, Logan, D.T, Nordlund, P. 登録日 2010-07-19 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Basis for Adenosylcobalamin Activation in AdoCbl-Dependent Ribonucleotide Reductases. Acs Chem.Biol., 5, 2010
3PAW	Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site 分子名称: Ribonucleoside-diphosphate reductase large chain 1 著者 Fairman, J.W, Wijerathna, S.R, Dealwis, C.G. 登録日 2010-10-19 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (6.61 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
5CNV	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to GDP and TTP at 3.20 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
1PEQ	Ribonucleotide Reductase Protein R1E from Salmonella typhimurium 分子名称: MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain, THYMIDINE-5'-TRIPHOSPHATE 著者 Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. 登録日 2003-05-22 公開日 2004-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
1PEU	Ribonucleotide Reductase Protein R1E from Salmonella typhimurium 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain 著者 Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. 登録日 2003-05-22 公開日 2004-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
5CNS	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.975 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNU	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5D1Y	Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP 分子名称: Ribonucleoside-diphosphate reductase large subunit 著者 Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L. 登録日 2015-08-04 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (9.005 Å) 主引用文献 Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry, 55, 2016
3HND	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNC	Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP 分子名称: MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3HNE	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3K8T	Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... 著者 Sun, D, Xu, H, Dealwis, C, Lee, R.E. 登録日 2009-10-14 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4, 2009
5CNT	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to UDP and dATP at 3.25 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
3HNF	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
1PEO	Ribonucleotide Reductase Protein R1E from Salmonella typhimurium 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 2 alpha chain 著者 Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. 登録日 2003-05-22 公開日 2004-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
1PEM	Ribonucleotide Reductase Protein R1E from Salmonella typhimurium 分子名称: Ribonucleoside-diphosphate reductase 2 alpha chain 著者 Uppsten, M, Farnegardh, M, Jordan, A, Eliasson, R, Eklund, H, Uhlin, U. 登録日 2003-05-22 公開日 2004-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structure of the large subunit of class Ib ribonucleotide reductase from Salmonella typhimurium and its complexes with allosteric effectors. J.Mol.Biol., 330, 2003
1R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN MUTANT Y730F WITH A REDUCED ACTIVE SITE FROM ESCHERICHIA COLI 分子名称: RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN 著者 Eriksson, M, Eklund, H. 登録日 1997-07-15 公開日 1998-01-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
6LKM	Crystal structure of Ribonucleotide reductase R1 subunit, RRM1 in complex with 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide 分子名称: 5-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-sulfonamide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Miyahara, S, Chong, K.T, Suzuki, T. 登録日 2019-12-19 公開日 2020-12-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity To be published
6AUI	Human ribonucleotide reductase large subunit (alpha) with dATP and CDP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. 登録日 2017-09-01 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
6MT9	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. 登録日 2018-10-19 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019
6MV9	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase, ... 著者 Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. 登録日 2018-10-24 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019

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