4YJE
| Crystal structure of APC-ARM in complexed with Amer1-A1 | 分子名称: | APC membrane recruitment protein 1, Adenomatous polyposis coli protein | 著者 | Zhang, Z, Xiao, Y, Wu, G. | 登録日 | 2015-03-03 | 公開日 | 2016-03-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners Cell Discov, 1, 2015
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3UL1
| Mouse importin alpha: nucleoplasmin cNLS peptide complex | 分子名称: | Importin subunit alpha-2, Nucleoplasmin | 著者 | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | 登録日 | 2011-11-10 | 公開日 | 2012-10-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
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1JDH
| CRYSTAL STRUCTURE OF BETA-CATENIN AND HTCF-4 | 分子名称: | BETA-CATENIN, hTcf-4 | 著者 | Graham, T.A, Ferkey, D.M, Mao, F, Kimelman, D, Xu, W. | 登録日 | 2001-06-13 | 公開日 | 2001-12-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Tcf4 can specifically recognize beta-catenin using alternative conformations. Nat.Struct.Biol., 8, 2001
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7RFZ
| Importin alpha 2 in complex with MERS ORF4B NLS peptide | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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5HUW
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7JK7
| Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant | 分子名称: | GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A | 著者 | Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. | 登録日 | 2020-07-27 | 公開日 | 2020-08-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020
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4U5U
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4U5V
| IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | 分子名称: | Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide | 著者 | Stewart, M, Valkov, E, Holvey, R.S. | 登録日 | 2014-07-25 | 公開日 | 2015-05-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.968 Å) | 主引用文献 | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design. Chemmedchem, 10, 2015
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5HUY
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5W4F
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6P6E
| Structure of Mouse Importin alpha - PAC3 NLS peptide complex | 分子名称: | Importin subunit alpha-1, PAC3 NLS | 著者 | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | 登録日 | 2019-06-03 | 公開日 | 2020-01-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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7UMI
| Importin a1 bound to Cp183-CTD | 分子名称: | HBV-NLS, Importin subunit alpha-1 | 著者 | Yang, R, Cingolani, G. | 登録日 | 2022-04-07 | 公開日 | 2023-10-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core. Sci Adv, 10, 2024
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5B6G
| Protein-protein interaction | 分子名称: | Adenomatous polyposis coli protein, GLYCEROL, PHQ-ALA-GLY-GLU-ALA-XYC-TYR-GLU, ... | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-05-27 | 公開日 | 2017-05-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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4BQK
| rice importin_alpha : VirD2NLS complex | 分子名称: | DI(HYDROXYETHYL)ETHER, IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER ENDONUCLEASE VIRD2 | 著者 | Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. | 登録日 | 2013-05-31 | 公開日 | 2014-02-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Structural Basis of Interaction of Bipartite Nuclear Localization Signal from Agrobacterium Vird2 with Rice Importin-Alpha Mol.Plant, 7, 2014
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5EKF
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3OQS
| Crystal structure of importin-alpha bound to a CLIC4 NLS peptide | 分子名称: | Importin subunit alpha-2, peptide of Chloride intracellular channel protein 4 | 著者 | Mynott, A.V, Brown, L.J, Harrop, S.J, Curmi, P.M.G. | 登録日 | 2010-09-03 | 公開日 | 2011-07-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 Febs J., 278, 2011
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7RG0
| Importin alpha2 in complex with MERS ORF4B R24A mutant | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG2
| Importin alpha2 in complex with MERS ORF4B R33A mutant | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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7RG3
| Importin alpha2 in complex with MERS ORF4B R37A mutant | 分子名称: | Importin subunit alpha-1, ORF4b | 著者 | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | 登録日 | 2021-07-14 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity. Nat Commun, 13, 2022
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8QXW
| HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 | 分子名称: | DNA polymerase processivity factor, Importin subunit alpha-1 | 著者 | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | 登録日 | 2023-10-25 | 公開日 | 2023-11-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
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3UL0
| Mouse importin alpha: mouse CBP80Y8D cNLS complex | 分子名称: | Importin subunit alpha-2, Nuclear cap-binding protein subunit 1 | 著者 | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | 登録日 | 2011-11-10 | 公開日 | 2012-10-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
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5SVZ
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1I7W
| BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX | 分子名称: | BETA-CATENIN, CHLORIDE ION, EPITHELIAL-CADHERIN, ... | 著者 | Huber, A.H, Weis, W.I. | 登録日 | 2001-03-10 | 公開日 | 2001-05-09 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell(Cambridge,Mass.), 105, 2001
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8TUQ
| STL Polyomavirus LTA NLS bound to importin alpha 2 | 分子名称: | Importin subunit alpha-1, Large T antigen | 著者 | Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. | 登録日 | 2023-08-17 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
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5WUM
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