PDB: 621 件ウェブページステータス検索Chemie searchBIRD

---

7BI3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-179 分子名称: 14-3-3 protein sigma, 4-[(6-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-12 公開日 2021-06-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BA8	Cys-42-tethered stabilizer 10 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-methyl-2-phenoxy-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
6HMU	Ternary complex of Estrogen Receptor alpha peptide and 14-3-3 sigma C45 mutant bound to disulfide fragment PPI stabilizer 6 分子名称: 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(3-sulfanylpropyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Hallenbeck, K.K, Leysen, S, Arkin, M.R, Ottmann, C. 登録日 2018-09-12 公開日 2019-02-27 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J. Am. Chem. Soc., 141, 2019
5MHC	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, LYS-LEU-MET-PHE-LYS-TPO-GLU-GLY-PRO-ASP-SER-ASP, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2016-11-24 公開日 2017-10-04 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
7AEW	14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs 分子名称: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ... 著者 Kiehstaller, S, Hennig, S. 登録日 2020-09-18 公開日 2020-11-04 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
5MXO	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide stabilized by Fusicoccin-A 分子名称: 14-3-3 protein sigma, CHLORIDE ION, FUSICOCCIN, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2017-01-24 公開日 2017-11-08 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
8APS	Small molecular stabilizer for ERalpha and 14-3-3 (1083744) 分子名称: 14-3-3 protein sigma, 2-chloranyl-1-[3-[(2R,6S)-4-[(4-chlorophenyl)amino]-2,6-dimethyl-oxan-4-yl]carbonyl-3,9-diazaspiro[5.5]undecan-9-yl]ethanone, Estrogen receptor, ... 著者 Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. 登録日 2022-08-10 公開日 2023-09-20 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145, 2023
7BIW	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-187 分子名称: 14-3-3 protein sigma, 4-(3,4-dihydro-2~{H}-quinoxalin-1-ylsulfonyl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-13 公開日 2021-09-15 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NXY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-181 分子名称: 14-3-3 protein sigma, 4-[(6-fluoranyl-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-19 公開日 2021-06-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O3A	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-046 分子名称: 1-[4-(hydroxymethyl)phenyl]sulfonylpiperidin-4-ol, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-04-01 公開日 2021-06-09 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NXS	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-184 分子名称: 14-3-3 protein sigma, 4-[(6-fluoranyl-2,3-dihydro-1,4-benzoxazin-4-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-19 公開日 2021-06-09 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NVI	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-186 分子名称: 14-3-3 protein sigma, 4-[(7-chloranyl-2,3-dihydro-1,4-benzoxazin-4-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-15 公開日 2021-06-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NV4	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-188 分子名称: 14-3-3 protein sigma, 4-(2,3-dihydroindol-1-ylsulfonyl)benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-15 公開日 2021-06-09 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NXT	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-183 分子名称: 14-3-3 protein sigma, 4-(2,3-dihydro-1,4-benzoxazin-4-ylsulfonyl)benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-19 公開日 2021-06-09 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
6RHC	Fragment AZ-003 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, 5-azanyl-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... 著者 Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Castaldi, P, Ottmann, C. 登録日 2019-04-19 公開日 2020-06-17 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
7NWS	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-185 分子名称: 14-3-3 protein sigma, 4-[(7-methoxy-2,3-dihydro-1,4-benzoxazin-4-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-17 公開日 2021-06-09 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7NXW	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-182 分子名称: 14-3-3 protein sigma, 4-[(6-chloranyl-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-03-19 公開日 2021-06-09 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O34	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-043 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, Transcription factor p65, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-04-01 公開日 2021-06-09 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7O59	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-192 分子名称: 14-3-3 protein sigma, 4-(5-methoxy-2-methyl-benzimidazol-1-yl)benzaldehyde, 4-(6-methoxy-2-methyl-benzimidazol-1-yl)benzaldehyde, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-04-08 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin 分子名称: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
6YOW	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521 分子名称: 14-3-3 protein sigma, 4-(methylsulfonyl)benzaldehyde, p65pS45 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
7NQP	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound LvD1009 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-03-02 公開日 2021-06-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8BZA	single soak stabilizer for ERa - 14-3-3 interaction (AZ555) 分子名称: 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... 著者 Visser, E.J, Sijbesma, E, Ottmann, C. 登録日 2022-12-14 公開日 2023-08-02 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
6QHM	14-3-3 sigma with RelA/p65 binding site pS281 分子名称: 14-3-3 protein sigma, LEU-SEP-GLU 著者 Wolter, M, Ottmann, C. 登録日 2019-01-16 公開日 2020-05-13 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
6FAU	Crystal structure of C-terminal modified Tau peptide-hybrid 4.2e-I with 14-3-3sigma 分子名称: (2~{R})-2-[(~{R})-(2-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... 著者 Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. 登録日 2017-12-18 公開日 2018-05-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018

<12345678910111213141516>