7NQP
14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound LvD1009
Summary for 7NQP
Entry DOI | 10.2210/pdb7nqp/pdb |
Related | 6QHL |
Descriptor | 14-3-3 protein sigma, Transcription factor p65, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, ... (5 entities in total) |
Functional Keywords | benzaldehyde, covalent fragment, p65, 1433, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 29990.43 |
Authors | Wolter, M.,Dijck, L.v.,Cossar, P.J.,Ottmann, C. (deposition date: 2021-03-02, release date: 2021-06-16, Last modification date: 2024-01-31) |
Primary citation | Cossar, P.J.,Wolter, M.,van Dijck, L.,Valenti, D.,Levy, L.M.,Ottmann, C.,Brunsveld, L. Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143:8454-8464, 2021 Cited by PubMed: 34047554DOI: 10.1021/jacs.1c03035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
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