PDB: 433 件ウェブページステータス検索Chemie searchBIRD

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5F6D	Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 分子名称: 6~{H}-benzo[c][1,2]benzothiazine 5,5-dioxide, SUMO-conjugating enzyme UBC9 著者 Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. 登録日 2015-12-05 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.553 Å) 主引用文献 Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
7AI0	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Magnussen, H.M, Huang, D.T. 登録日 2020-09-25 公開日 2021-01-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.559 Å) 主引用文献 Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
5F6X	Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from cocktail screen) 分子名称: 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 著者 Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. 登録日 2015-12-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
5D1M	Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A) 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ... 著者 Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. 登録日 2015-08-04 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.581 Å) 主引用文献 Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
1JAT	Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex 分子名称: Ubiquitin-Conjugating Enzyme E2-17.5 KDA, Ubiquitin-Conjugating Enzyme Variant Mms2 著者 VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. 登録日 2001-05-31 公開日 2001-06-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell(Cambridge,Mass.), 105, 2001
4GPR	Crystal structure of EhUbc5, a ubiquitin conjugating enzyme from Entamoeba histolytica 分子名称: COBALT (II) ION, Ubiquitin-conjugating enzyme family protein 著者 Bosch, D.E, Siderovski, D.P. 登録日 2012-08-21 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica. J.Biol.Chem., 288, 2013
3L1Y	Crystal structure of human UBC4 E2 conjugating enzyme 分子名称: Ubiquitin-conjugating enzyme E2 D2 著者 Benirschke, R, Thompson, J.R, Mer, G. 登録日 2009-12-14 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4. Structure, 18, 2010
3BZH	Crystal structure of human ubiquitin-conjugating enzyme E2 E1 分子名称: GLYCEROL, Ubiquitin-conjugating enzyme E2 E1 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2008-01-18 公開日 2008-02-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
5D1L	Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A) 分子名称: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ... 著者 Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. 登録日 2015-08-04 公開日 2015-10-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.618 Å) 主引用文献 Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
6NYD	Crystal Structure of S. cerevisiae Ubc3 (Cdc34) 分子名称: ACETATE ION, Ubiquitin-conjugating enzyme E2-34 kDa, ZINC ION 著者 Olsen, S.K, Williams, K.M, Atkison, J.H. 登録日 2019-02-11 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34. Nat Commun, 10, 2019
7V8F	Crystal structure of UBE2L3 bound to HOIP RING1 domain. 分子名称: E3 ubiquitin-protein ligase RNF31, Ubiquitin-conjugating enzyme E2 L3, ZINC ION 著者 Liu, J, Wang, Y, Pan, L. 登録日 2021-08-22 公開日 2022-03-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA, 119, 2022
9BIV	Crystal Structure of Ubc13 with a New Active Site Loop Conformation 分子名称: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 著者 Farraj, R.A, Edwards, R.A, Glover, J.N.M. 登録日 2024-04-24 公開日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystal Structure of Ubc13 with a New Active Site Loop Conformation To Be Published
2A4D	Structure of the human ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) 分子名称: Ubiquitin-conjugating enzyme E2 variant 1 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2005-06-28 公開日 2005-07-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
8JVD	Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening 分子名称: 5-fluoranyl-1,3-benzoxazol-2-amine, Ubiquitin-conjugating enzyme E2 T 著者 Anantharajan, J, Baburajendran, N. 登録日 2023-06-28 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.696 Å) 主引用文献 Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening. Protein Sci., 33, 2024
5F6W	Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) 分子名称: 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 著者 Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. 登録日 2015-12-07 公開日 2016-04-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.699 Å) 主引用文献 Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
8WR5	The Crystal Structure of Mms2 from Biortus 分子名称: 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin-conjugating enzyme E2 variant 2 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. 登録日 2023-10-13 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Crystal Structure of Mms2 from Biortus. To Be Published
8GXR	crystal structure of UBC domain of UBE2O 分子名称: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O, CITRIC ACID 著者 Fu, Z, Zhu, W, Huang, H. 登録日 2022-09-21 公開日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 crystal structure of UBE2O To Be Published
6HPR	Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub 分子名称: Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ... 著者 Patel, A, Huang, D.T. 登録日 2018-09-21 公開日 2018-12-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex. J. Biol. Chem., 294, 2019
6ZM3	The structure of an E2 ubiquitin-conjugating complex (UBC2-UEV1) essential for Leishmania amastigote differentiation 分子名称: Putative ubiquitin-conjugating enzyme e2, Ubiquitin-conjugating enzyme-like protein 著者 Burge, R.J, Dodson, E.J, Wilkinson, A.J, Mottram, J.C. 登録日 2020-07-01 公開日 2020-07-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex. Plos Pathog., 16, 2020
3WE5	Crystal structure of ubiquitin conjugating enzyme E2 UbcA1 from Agrocybe aegerita 分子名称: ACETIC ACID, GLYCEROL, Ubiquitin conjugating enzyme 著者 Li, D.F, Feng, L, Wang, D.C, Liu, W. 登録日 2013-07-01 公開日 2014-07-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of ubiquitin conjugating enzyme E2 UbcA1 from Agrocybe aegerita To be Published
2GRO	Crystal Structure of human RanGAP1-Ubc9-N85Q 分子名称: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I 著者 Yunus, A.A, Lima, C.D. 登録日 2006-04-24 公開日 2006-05-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
2GRQ	Crystal Structure of human RanGAP1-Ubc9-D127A 分子名称: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I 著者 Yunus, A.A, Lima, C.D. 登録日 2006-04-24 公開日 2006-05-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
6OP8	S. pombe Ubc7/U7BR complex 分子名称: 1,2-ETHANEDIOL, CUE domain-containing protein 4, mitochondrial, ... 著者 Hann, Z.S, Lima, C.D. 登録日 2019-04-24 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7. Acta Crystallogr.,Sect.F, 75, 2019
7LEW	Crystal structure of UBE2G2 in complex with the UBE2G2-binding region of AUP1 分子名称: Lipid droplet-regulating VLDL assembly factor AUP1, Ubiquitin-conjugating enzyme E2 G2 著者 Liang, Y.-H, Smith, C.E, Tsai, Y.C, Weissman, A.M, Ji, X. 登録日 2021-01-15 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.736 Å) 主引用文献 A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation. Plos Biol., 19, 2021
8GBQ	Structure of RNF125 in complex with UbcH5b 分子名称: E3 ubiquitin-protein ligase RNF125, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... 著者 Middleton, A.J, Day, C.L, Fokkens, T.J. 登録日 2023-02-27 公開日 2023-07-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023

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