PDB: 117 件ウェブページステータス検索Chemie searchBIRD

---

6U8X	Crystal structure of DNMT3B-DNMT3L in complex with CpApG DNA 分子名称: CpApG DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... 著者 Gao, L, Song, J. 登録日 2019-09-06 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95063877 Å) 主引用文献 Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nat Commun, 11, 2020
6U91	Crystal structure of DNMT3B(Q772R)-DNMT3L in complex with CpGpT DNA 分子名称: CpGpT DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B, ... 著者 Gao, L, Song, J. 登録日 2019-09-06 公開日 2020-06-10 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.99998879 Å) 主引用文献 Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms To Be Published
1SVU	Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions 分子名称: Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Dong, A, Zhou, L, Zhang, X, Stickel, S, Roberts, R.J, Cheng, X. 登録日 2004-03-30 公開日 2004-06-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions Biol.Chem., 385, 2004
1SKM	HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site 分子名称: 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', 5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', Modification methylase HhaI, ... 著者 Horton, J.R, Ratner, G, Banavali, N, Huang, N, Marquez, V.E, MacKerell, A.D, Cheng, X. 登録日 2004-03-05 公開日 2004-08-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase Nucleic Acids Res., 32, 2004
1M0E	ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE 分子名称: 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ... 著者 Zhou, L, Cheng, X, Connolly, B.A, Dickman, M.J, Hurd, P.J, Hornby, D.P. 登録日 2002-06-12 公開日 2002-09-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES J.MOL.BIOL., 321, 2002
3G7U	Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli) 分子名称: CHLORIDE ION, Cytosine-specific methyltransferase, GLYCEROL 著者 Patskovsky, Y, Ramagopal, U.A, Toro, R, Gilmore, M, Iizuka, M, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2009-02-10 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli) To be Published
2UZ4	HhaI DNA methyltransferase R165N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH 分子名称: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP*GP *AP*C)-3', GLYCEROL, ... 著者 Daujotyte, D, Leinartaite, L, Grazulis, S. 登録日 2007-04-25 公開日 2008-06-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 DNA Methyltransferase R165N Mutant To be Published
7X9D	DNMT3B in complex with harmine 分子名称: 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B 著者 Cho, C.-C, Yuan, H.S. 登録日 2022-03-15 公開日 2023-03-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth. Acs Chem.Biol., 18, 2023
2I9K	Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI 分子名称: 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE 著者 Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. 登録日 2006-09-05 公開日 2006-10-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI J.Mol.Biol., 362, 2006
2UYH	HhaI DNA methyltransferase S87Q-Q237S mutant complex with 13mer GCGC- GMGC oligonucleotide and SAH 分子名称: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*G*5CMP*GP*CP*TP*GP *AP*C)-3', MODIFICATION METHYLASE HHAI, ... 著者 Daujotyte, D, Grazulis, S. 登録日 2007-04-06 公開日 2008-05-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 HhaI DNA Methyltransferase S87Q-Q237S Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2UYC	HhaI DNA methyltransferase R163N mutant complex with 13mer GCGC-GMGC oligonucleotide and SAH 分子名称: 5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP *CP*C)-3', 5'-D(*TP*GP*GP*AP*TP*GP*5CMP*GP*CP*TP *GP*AP*C)-3', GLYCEROL, ... 著者 Daujotyte, D, Grazulis, S. 登録日 2007-04-03 公開日 2008-05-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 HhaI DNA Methyltransferase R163N Mutant Complex with 13mer Gcgc-Gmgc Oligonucleotide and Sah To be Published
2HMY	BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE 分子名称: PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE 著者 O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. 登録日 1999-02-08 公開日 1999-03-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. J.Mol.Biol., 287, 1999
2HR1	Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy 分子名称: 5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ... 著者 Shieh, F. 登録日 2006-07-19 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI. J.Mol.Biol., 362, 2006
8C58	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA 分子名称: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... 著者 Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. 登録日 2023-01-06 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C57	CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA 分子名称: CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... 著者 Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. 登録日 2023-01-06 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C56	CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA 分子名称: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... 著者 Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. 登録日 2023-01-06 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
8C59	CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA 分子名称: CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... 著者 Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. 登録日 2023-01-06 公開日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Cytosine analogues as DNA methyltransferase substrates and inhibitors To Be Published
2C7P	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... 著者 Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. 登録日 2005-11-25 公開日 2005-12-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7R	HhaI DNA methyltransferase (T250G mutant) complex with oligonucleotide containing 2-aminopurine as a target base (GPGC:GMGC) and SAH 分子名称: 5'-D(*G*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*(2PR)*GP*CP*AP*TP*CP*C)-3', GLYCEROL, ... 著者 Daujotyte, D, Grazulis, S. 登録日 2005-11-27 公開日 2005-12-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7O	HhaI DNA methyltransferase complex with 13mer oligonucleotide containing 2-aminopurine adjacent to the target base (PCGC:GMGC) and SAH 分子名称: 5'-D(*T*GP*GP*AP*TP*GP*(5CM)*GP*CP*TP*GP*AP *C)-3', 5'-D(*T*GP*TP*CP*AP*(2PR)*CP*GP*CP*AP*TP*CP *C)-3', MODIFICATION METHYLASE HHAI, ... 著者 Daujotyte, D, Grazulis, S. 登録日 2005-11-25 公開日 2005-12-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes. Nucleic Acids Res., 33, 2005
2C7Q	HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine outside the recognition sequence (paired with G) and SAH 分子名称: 5'-D(*T*GP*GP*(2PR)*GP*GP*(5CM)*GP*CP*TP*GP* AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*CP*GP*CP*CP*GP*CP*C)-3', CITRIC ACID, ... 著者 Daujotyte, D, Grazulis, S. 登録日 2005-11-27 公開日 2005-12-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes Nucleic Acids Res., 33, 2005
4H0N	Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant 分子名称: CALCIUM ION, DNMT2, S-ADENOSYL-L-HOMOCYSTEINE 著者 Li, S, Du, J, Yang, H, Yin, J, Zhong, J, Ding, J. 登録日 2012-09-09 公開日 2012-11-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.712 Å) 主引用文献 Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol, 5, 2013
8T1U	Crystal structure of the DRM2-CTA DNA complex 分子名称: DNA (5'-D(P*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*AP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*TP*TP*TP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... 著者 Chen, J, Lu, J, Song, J. 登録日 2023-06-03 公開日 2023-11-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 DNA conformational dynamics in the context-dependent non-CG CHH methylation by plant methyltransferase DRM2. J.Biol.Chem., 299, 2023
8TDR	Crystal structure of the methyltransferase domain of DNMT3A homotetramer 分子名称: DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE 著者 Lu, J.W, Song, J.K. 登録日 2023-07-04 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Crystal structure of the homo-tetrameric DNMT3A methyltransferase domain To Be Published
8TE4	Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer 分子名称: DNA (cytosine-5)-methyltransferase 3A, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE 著者 Lu, J.W, Song, J.K. 登録日 2023-07-05 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer To Be Published

<12345>