4M3K
 
 | | Structure of a single domain camelid antibody fragment cAb-H7S in complex with the BlaP beta-lactamase from Bacillus licheniformis | | 分子名称: | Beta-lactamase, CHLORIDE ION, Camelid heavy-chain antibody variable fragment cAb-H7S | | 著者 | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | 登録日 | 2013-08-06 | | 公開日 | 2014-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To be Published
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6T7L
 | | Crystal structure of AmpC from E.coli with Nacubactam (OP0595) | | 分子名称: | (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, ... | | 著者 | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | | 登録日 | 2019-10-22 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes.
Antimicrob.Agents Chemother., 65, 2021
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6T35
 | | Crystal structure of AmpC from E.coli with Enmetazobactam (AAI-101) | | 分子名称: | Beta-lactamase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. | | 登録日 | 2019-10-10 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8TTP
 | | Crystal structure of class C beta-lactamase from Escherichia coli in complex with avibactam | | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, Beta-lactamase, ... | | 著者 | Chang, C, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | 登録日 | 2023-08-14 | | 公開日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Crystal structure of class C beta-lactamase from Escherichia coli in complex with avibactam
to be published
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5LWF
 | | Structure of a single domain camelid antibody fragment cAb-G10S in complex with the BlaP beta-lactamase from Bacillus licheniformis | | 分子名称: | ACETATE ION, Beta-lactamase, Camelid heavy-chain antibody variable fragment cAb-G10S | | 著者 | Vettore, N, Kerff, F, Pain, C, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | | 登録日 | 2016-09-16 | | 公開日 | 2017-11-15 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments
To Be Published
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6PWL
 | | ADC-7 in complex with boronic acid transition state inhibitor LP06 | | 分子名称: | (7Z)-7-(2-amino-1,3-thiazol-4-yl)-1,1,3-trihydroxy-10,10-dimethyl-1,6-dioxo-2,9-dioxa-5,8-diaza-1lambda~5~-phospha-3-boraundec-7-en-11-oic acid, Beta-lactamase, GLYCINE | | 著者 | Curtis, B.C, Powers, R.A, Wallar, B.J. | | 登録日 | 2019-07-23 | | 公開日 | 2020-10-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog.
Antimicrob.Agents Chemother., 64, 2020
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5JOC
 | | Crystal structure of the S61A mutant of AmpC BER | | 分子名称: | Beta-lactamase, CITRIC ACID | | 著者 | Na, J.H, An, Y.J, Cha, S.S. | | 登録日 | 2016-05-02 | | 公開日 | 2017-05-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for the extended substrate spectrum of AmpC BER and structure-guided discovery of the inhibition activity of citrate against the class C beta-lactamases AmpC BER and CMY-10.
Acta Crystallogr D Struct Biol, 72, 2016
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5K1F
 | | Crystal structure of a class C beta lactamase/compound2 complex | | 分子名称: | Beta-lactamase, CADMIUM ION, INOSINIC ACID | | 著者 | An, Y.J, Na, J.H, Cha, S.S. | | 登録日 | 2016-05-18 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase.
Antimicrob. Agents Chemother., 61, 2017
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5K1D
 | | Crystal structure of a class C beta lactamase/compound1 complex | | 分子名称: | Beta-lactamase, CADMIUM ION, GUANOSINE-5'-MONOPHOSPHATE | | 著者 | AN, Y.J, Na, J.H, Cha, S.S. | | 登録日 | 2016-05-18 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase.
Antimicrob. Agents Chemother., 61, 2017
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7PU6
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7PP3
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5WAD
 | | ADC-7 in complex with boronic acid transition state inhibitor CR161 | | 分子名称: | Beta-lactamase, PHOSPHATE ION, phosphonooxy-[[[6-(1~{H}-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]sulfonylamino]methyl]borinic acid | | 著者 | Powers, R.A, Wallar, B.J. | | 登録日 | 2017-06-26 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase.
ACS Infect Dis, 4, 2018
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5WAF
 | | ADC-7 in complex with boronic acid transition state inhibitor CR192 | | 分子名称: | Beta-lactamase, phosphonooxy-[[[4-(1~{H}-1,2,3,4-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]sulfonylamino]methyl]borinic acid | | 著者 | Powers, R.A, Wallar, B.J. | | 登録日 | 2017-06-26 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase.
ACS Infect Dis, 4, 2018
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6DPX
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7MQN
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6I30
 | | Crystal structure of the AmpC from Pseudomonas aeruginosa with 1C | | 分子名称: | (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Class C beta-lactamase PDC-301 | | 著者 | Brem, J, Cahill, S.T, McDonough, M.A, Schofield, C.J. | | 登録日 | 2018-11-02 | | 公開日 | 2019-02-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Studies on the inhibition of AmpC and other beta-lactamases by cyclic boronates.
Biochim Biophys Acta Gen Subj, 1863, 2019
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5XHR
 | | Crystal structure of P99 beta-lactamase in complex with a penicillin derivative MPC-1 | | 分子名称: | (2~{R},4~{S})-5,5-dimethyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-5-thiophen-2-yl-pentan-2-yl]-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase | | 著者 | Pan, X, Zhao, Y. | | 登録日 | 2017-04-24 | | 公開日 | 2017-09-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C beta-Lactamases
Antimicrob. Agents Chemother., 61, 2017
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7MDC
 | | Full-length wildtype ClbP inhibited by hexanoyl-D-asparagine boronic acid | | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, Beta-lactamase, CHLORIDE ION, ... | | 著者 | Velilla, J.A, Volpe, M.R, Gaudet, R. | | 登録日 | 2021-04-03 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | A small molecule inhibitor prevents gut bacterial genotoxin production.
Nat.Chem.Biol., 19, 2023
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7MDE
 | | Full-length S95A ClbP | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Beta-lactamase, CHLORIDE ION, ... | | 著者 | Velilla, J.A, Volpe, M.R, Gaudet, R. | | 登録日 | 2021-04-04 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of colibactin activation by the ClbP peptidase.
Nat.Chem.Biol., 19, 2023
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7MDF
 | | Full-length S95A ClbP bound to N-acyl-D-asparagine analog | | 分子名称: | (2S)-2,3-dihydroxypropyl (9Z)-hexadec-9-enoate, Beta-lactamase, CHLORIDE ION, ... | | 著者 | Velilla, J.A, Volpe, M.R, Gaudet, R. | | 登録日 | 2021-04-04 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis of colibactin activation by the ClbP peptidase.
Nat.Chem.Biol., 19, 2023
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7PP8
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5WAC
 | | ADC-7 in complex with boronic acid transition state inhibitor CR157 | | 分子名称: | Beta-lactamase, phosphonooxy-[[[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]sulfonylamino]methyl]borinic acid | | 著者 | Powers, R.A, Wallar, B.J. | | 登録日 | 2017-06-26 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.061 Å) | | 主引用文献 | Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase.
ACS Infect Dis, 4, 2018
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5WAG
 | | ADC-7 in complex with boronic acid transition state inhibitor S06017 | | 分子名称: | 1-{[hydroxy(phosphonooxy)boranyl]methyl}-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, SUCCINIC ACID | | 著者 | Powers, R.A, Wallar, B.J. | | 登録日 | 2017-06-26 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.931 Å) | | 主引用文献 | Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase.
ACS Infect Dis, 4, 2018
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5ZFL
 | | Crystal structure of beta-lactamase PenP mutant E166Y | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase | | 著者 | Pan, X, Zhao, Y. | | 登録日 | 2018-03-06 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The hydrolytic water molecule of Class A beta-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis.
Sci Rep, 10, 2020
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5ZG6
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