5XHR

Crystal structure of P99 beta-lactamase in complex with a penicillin derivative MPC-1

Summary for 5XHR

Entry DOI	10.2210/pdb5xhr/pdb
Descriptor	Beta-lactamase, (2~{R},4~{S})-5,5-dimethyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-5-thiophen-2-yl-pentan-2-yl]-1,3-thiazolidine-4-carboxylic acid (3 entities in total)
Functional Keywords	hydrolase
Biological source	Enterobacter cloacae
Cellular location	Periplasm : P05364
Total number of polymer chains	1
Total formula weight	39911.52
Authors	Pan, X.,Zhao, Y. (deposition date: 2017-04-24, release date: 2017-09-27, Last modification date: 2023-11-22)
Primary citation	Pan, X.,He, Y.,Chen, T.,Chan, K.F.,Zhao, Y. Modified Penicillin Molecule with Carbapenem-Like Stereochemistry Specifically Inhibits Class C beta-Lactamases Antimicrob. Agents Chemother., 61:-, 2017 Cited by PubMed: 28971874 DOI: 10.1128/AAC.01288-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation