5XHR
Crystal structure of P99 beta-lactamase in complex with a penicillin derivative MPC-1
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue PXH A 401 |
| Chain | Residue |
| A | SER64 |
| A | SER318 |
| A | ASN346 |
| A | HOH510 |
| A | HOH515 |
| A | HOH524 |
| A | GLN120 |
| A | TYR150 |
| A | ASN152 |
| A | TYR221 |
| A | LEU293 |
| A | LYS315 |
| A | THR316 |
| A | GLY317 |
Functional Information from PROSITE/UniProt
| site_id | PS00336 |
| Number of Residues | 8 |
| Details | BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSISK |
| Chain | Residue | Details |
| A | PHE60-LYS67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 257 |
| Chain | Residue | Details |
| A | SER64 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS67 | electrostatic stabiliser, hydrogen bond donor, increase acidity |
| A | TYR150 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU272 | electrostatic stabiliser, hydrogen bond acceptor |
| A | LYS315 | electrostatic stabiliser, hydrogen bond donor, increase acidity |
| A | SER318 | electrostatic stabiliser, hydrogen bond donor |
