PDB: 226 件ウェブページステータス検索Chemie searchBIRD

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4L79	Crystal Structure of nucleotide-free Myosin 1b residues 1-728 with bound Calmodulin 分子名称: Calmodulin, MAGNESIUM ION, Unconventional myosin-Ib 著者 Shuman, H, Zwolak, A, Dominguez, R, Ostap, E.M. 登録日 2013-06-13 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning. Proc.Natl.Acad.Sci.USA, 111, 2014
1YV3	The structural basis of blebbistatin inhibition and specificity for myosin II 分子名称: (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Allingham, J.S, Smith, R, Rayment, I. 登録日 2005-02-14 公開日 2005-03-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structural basis of blebbistatin inhibition and specificity for myosin II. Nat.Struct.Mol.Biol., 12, 2005
7DHW	Crystal structure of myosin-XI motor domain in complex with ADP-ALF4 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Suzuki, K, Haraguchi, T, Tamanaha, M, Yoshimura, K, Imi, T, Tominaga, M, Sakayama, H, Nishiyama, T, Ito, K, Murata, T. 登録日 2020-11-17 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Discovery of ultrafast myosin, its amino acid sequence, and structural features. Proc.Natl.Acad.Sci.USA, 119, 2022
3DTP	Tarantula heavy meromyosin obtained by flexible docking to Tarantula muscle thick filament Cryo-EM 3D-MAP 分子名称: Myosin II regulatory light chain, Myosin light polypeptide 6, Myosin-11,Myosin-7 著者 Alamo, L, Wriggers, W, Pinto, A, Bartoli, F, Salazar, L, Zhao, F.Q, Craig, R, Padron, R. 登録日 2008-07-15 公開日 2008-10-07 最終更新日 2020-01-29 実験手法 ELECTRON MICROSCOPY (20 Å) 主引用文献 Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity J.Mol.Biol., 384, 2008
3BZ8	Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II 分子名称: (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Allingham, J.S, Rayment, I. 登録日 2008-01-17 公開日 2008-02-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
8A12	Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Moussaoui, D, Robblee, J.P, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Mueller-Dieckmann, C, Baum, J, Robert-Paganin, J, Trybus, K.M, Houdusse, A. 登録日 2022-05-31 公開日 2023-06-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nat Commun, 14, 2023
3BZ7	Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II 分子名称: (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Allingham, J.S, Rayment, I. 登録日 2008-01-17 公開日 2008-02-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
8EXW	Drosophila melanogaster indirect flight muscle myosin II (subfragment-1) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Isoform K of Myosin heavy chain, muscle, ... 著者 Caldwell, J.T, Huxford, T, Bernstein, S.I, Stec, B. 登録日 2022-10-25 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Drosophila melanogaster indirect flight muscle myosin II (subfragment-1) To Be Published
4ZLK	Crystal structure of mouse myosin-5a in complex with calcium-bound calmodulin 分子名称: CALCIUM ION, Calmodulin, Unconventional myosin-Va 著者 Shen, M, Zhang, N, Zheng, S, Zhang, W.-B, Zhang, H.-M, Lu, Z, Su, Q.P, Sun, Y, Ye, K, Li, X.-D. 登録日 2015-05-01 公開日 2016-05-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structural basis for calcium regulation of myosin 5 motor function To Be Published
7MF3	Structure of the autoinhibited state of smooth muscle myosin-2 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light polypeptide 6, ... 著者 Heissler, S.M, Arora, A.S, Billington, N, Sellers, J.R, Chinthalapudi, K. 登録日 2021-04-08 公開日 2022-01-05 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structure of the autoinhibited state of myosin-2. Sci Adv, 7, 2021
8ACT	structure of the human beta-cardiac myosin folded-back off state 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light chain 3, ... 著者 Grinzato, A, Kandiah, E, Robert-Paganin, J, Auguin, D, Kikuti, C, Nandwani, N, Moussaoui, D, Pathak, D, Ruppel, K.M, Spudich, J.A, Houdusse, A. 登録日 2022-07-06 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structure of the folded-back state of human beta-cardiac myosin. Nat Commun, 14, 2023
1S5G	Structure of Scallop myosin S1 reveals a novel nucleotide conformation 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... 著者 Risal, D, Gourinath, S, Himmel, D.M, Szent-Gyorgyi, A.G, Cohen, C. 登録日 2004-01-20 公開日 2004-06-22 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding. Proc.Natl.Acad.Sci.Usa, 101, 2004
2JHR	Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate and pentabromopseudilin 分子名称: ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN, ... 著者 Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. 登録日 2008-03-25 公開日 2009-01-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity. Nat.Struct.Mol.Biol., 16, 2009
2JJ9	Crystal structure of myosin-2 in complex with ADP-metavanadate 分子名称: ADP METAVANADATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN 著者 Fedorov, R, Boehl, M, Tsiavaliaris, G, Hartmann, F.K, Baruch, P, Brenner, B, Martin, R, Knoelker, H.J, Gutzeit, H.O, Manstein, D.J. 登録日 2008-03-25 公開日 2009-01-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Mechanism of Pentabromopseudilin Inhibition of Myosin Motor Activity. Nat.Struct.Mol.Biol., 16, 2009
1SR6	Structure of nucleotide-free scallop myosin S1 分子名称: CALCIUM ION, MAGNESIUM ION, Myosin essential light chain, ... 著者 Risal, D, Gourinath, S, Himmel, D.M, Szent-Gyorgyi, A.G, Cohen, C. 登録日 2004-03-22 公開日 2004-06-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding. Proc.Natl.Acad.Sci.Usa, 101, 2004
5M05	Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form 分子名称: 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Sirigu, S, Hartman, J, Houdusse, A. 登録日 2016-10-03 公開日 2016-11-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.675 Å) 主引用文献 Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6UI4	Crystal structure of phenamacril-bound F. graminearum myosin I 分子名称: Calmodulin, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Zhou, Y, Zhou, X.E, Gong, Y, Zhu, Y, Xu, H.E, Zhou, M, Melcher, K, Zhang, F. 登録日 2019-09-30 公開日 2020-03-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis of Fusarium myosin I inhibition by phenamacril. Plos Pathog., 16, 2020
5T45	Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form 分子名称: 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... 著者 Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A. 登録日 2016-08-29 公開日 2016-11-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5TBY	HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240) 分子名称: Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, ... 著者 ALAMO, L, WARE, J.S, PINTO, A, GILLILAN, R.E, SEIDMAN, J.G, SEIDMAN, C.E, PADRON, R. 登録日 2016-09-13 公開日 2017-06-07 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (20 Å) 主引用文献 Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes. Elife, 6, 2017
1FMV	CRYSTAL STRUCTURE OF THE APO MOTOR DOMAIN OF DICTYOSTELLIUM MYOSIN II 分子名称: CHLORIDE ION, MYOSIN II HEAVY CHAIN 著者 Bauer, C.B, Holden, H.M, Thoden, J.B, Smith, R, Rayment, I. 登録日 2000-08-18 公開日 2000-11-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain. J.Biol.Chem., 275, 2000
1FMW	CRYSTAL STRUCTURE OF THE MGATP COMPLEX FOR THE MOTOR DOMAIN OF DICTYOSTELIUM MYOSIN II 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, MYOSIN II HEAVY CHAIN 著者 Bauer, C.B, Holden, H.M, Thoden, J.B, Smith, R, Rayment, I. 登録日 2000-08-18 公開日 2000-11-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain. J.Biol.Chem., 275, 2000
1G8X	STRUCTURE OF A GENETICALLY ENGINEERED MOLECULAR MOTOR 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN II HEAVY CHAIN FUSED TO ALPHA-ACTININ 3 著者 Kliche, W, Fujita-Becker, S, Kollmar, M, Manstein, D.J, Kull, F.J. 登録日 2000-11-21 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of a genetically engineered molecular motor. EMBO J., 20, 2001
5N69	Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil 分子名称: 3,3',3''-phosphanetriyltripropanoic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. 登録日 2017-02-14 公開日 2017-08-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
5N6A	Cardiac muscle myosin motor domain in the pre-powerstroke state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. 登録日 2017-02-14 公開日 2017-08-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
2OTG	Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... 著者 Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. 登録日 2007-02-08 公開日 2007-05-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor. Structure, 15, 2007

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