2MPF
 
 | | Solution structure human HCN2 CNBD in the cAMP-unbound state | | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | 著者 | Saponaro, A, Pauleta, S.R, Cantini, F, Matzapetakis, M, Hammann, C, Banci, L, Thiel, G, Santoro, B, Moroni, A. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Proc.Natl.Acad.Sci.USA, 111, 2014
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1RL3
 | | Crystal structure of cAMP-free R1a subunit of PKA | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory chain | | 著者 | Wu, J, Brown, S, Xuong, N.-H, Taylor, S.S. | | 登録日 | 2003-11-24 | | 公開日 | 2004-07-06 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.
Structure, 12, 2004
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2Z69
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1Q3E
 | | HCN2J 443-645 in the presence of cGMP | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | 著者 | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | | 登録日 | 2003-07-29 | | 公開日 | 2003-09-09 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for modulation and agonist specificity of HCN pacemaker channels
Nature, 425, 2003
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6BQ8
 | | Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... | | 著者 | Kim, C, Kovalevsky, A, Gerlits, O. | | 登録日 | 2017-11-27 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | | 主引用文献 | Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.
Biochemistry, 57, 2018
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1Q43
 | | HCN2I 443-640 in the presence of cAMP, selenomethionine derivative | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | 著者 | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | | 登録日 | 2003-08-01 | | 公開日 | 2003-09-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for modulation and agonist specificity of HCN pacemaker channels
Nature, 425, 2003
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1RGS
 | | REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP DEPENDENT PROTEIN KINASE | | 著者 | Su, Y, Dostmann, W.R.G, Herberg, F.W, Durick, K, Xuong, N.-H, Ten Eyck, L, Taylor, S.S, Varughese, K.I. | | 登録日 | 1995-06-21 | | 公開日 | 1996-12-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science, 269, 1995
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6CPB
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1Q5O
 | | HCN2J 443-645 in the presence of cAMP, selenomethionine derivative | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | | 著者 | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | | 登録日 | 2003-08-08 | | 公開日 | 2003-09-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | STRUCTURAL BASIS FOR MODULATION AND AGONIST SPECIFICITY OF HCN PACEMAKER CHANNELS
Nature, 425, 2003
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2D93
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3MDP
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5V30
 | | Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | | 分子名称: | GLYCEROL, SULFATE ION, Transcriptional regulator | | 著者 | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Lewis, J.P. | | 登録日 | 2017-03-06 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.
Acta Crystallogr D Struct Biol, 75, 2019
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5T3N
 | | Sp-2Cl-cAMPS bound to PKAR CBD2 | | 分子名称: | (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyltetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-2-one, IODIDE ION, cAMP-dependent protein kinase regulatory subunit | | 著者 | Littler, D.R, Gilson, P. | | 登録日 | 2016-08-26 | | 公開日 | 2016-10-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Disrupting the Allosteric Interaction between the Plasmodium falciparum cAMP-dependent Kinase and Its Regulatory Subunit.
J. Biol. Chem., 291, 2016
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7LZ4
 | | Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed | | 著者 | Del Rio, J, Wu, J, Taylor, S.S. | | 登録日 | 2021-03-08 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (4.155 Å) | | 主引用文献 | Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MBJ
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1NE6
 | | Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase | | 分子名称: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain | | 著者 | Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S. | | 登録日 | 2002-12-10 | | 公開日 | 2004-01-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
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1NE4
 | | Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase | | 分子名称: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain | | 著者 | Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S. | | 登録日 | 2002-12-10 | | 公開日 | 2004-01-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP.
Biochemistry, 43, 2004
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4OFF
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4OFG
 | | Co-crystal structure of carboxy cGMP binding domain of Plasmodium falciparum PKG with cGMP | | 分子名称: | CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE, ETHANOL, ... | | 著者 | Kim, J.J, Sanabria figueroa, E, Kim, C. | | 登録日 | 2014-01-14 | | 公開日 | 2015-01-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Plos Pathog., 11, 2015
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4NVP
 | | Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP | | 分子名称: | (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | 著者 | Alfieri, A, Moroni, A. | | 登録日 | 2013-12-05 | | 公開日 | 2014-03-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
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4MUV
 | | M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP bound | | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated potassium channel mll3241, SODIUM ION | | 著者 | Fonseca, F, Pessoa, J, Morais-Cabral, J.H. | | 登録日 | 2013-09-23 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Determinants of ligand selectivity in a cyclic nucleotide-regulated potassium channel.
J.Gen.Physiol., 144, 2014
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3U11
 | | Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | | 著者 | Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A. | | 登録日 | 2011-09-29 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
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5BV6
 | | PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with cGMP | | 分子名称: | ACETATE ION, CALCIUM ION, GUANOSINE-3',5'-MONOPHOSPHATE, ... | | 著者 | Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. | | 登録日 | 2015-06-04 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
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5C6C
 | | PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cAMP | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CADMIUM ION, ... | | 著者 | Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. | | 登録日 | 2015-06-22 | | 公開日 | 2016-01-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
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3UKN
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