PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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2BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES 分子名称: DNAK 著者 Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. 登録日 1998-08-11 公開日 1999-03-02 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
2BUP	T13G Mutant of the ATPASE fragment of Bovine HSC70 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Sousa, M.C, Mckay, D.B. 登録日 1998-09-08 公開日 1998-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry, 37, 1998
3QFP	Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain 分子名称: 78 kDa glucose-regulated protein homolog, PHOSPHATE ION 著者 Yan, M, Li, J.Z, Sha, B.D. 登録日 2011-01-22 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
3QNJ	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin 分子名称: Chaperone protein DnaK, SULFATE ION, antimicrobial peptide oncocin 著者 Zahn, M, Straeter, N. 登録日 2011-02-08 公開日 2011-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex. Chembiochem, 12, 2011
3QFU	Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP 分子名称: 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Yan, M, Li, J.Z, Sha, B.D. 登録日 2011-01-22 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... 著者 Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. 登録日 2019-09-05 公開日 2020-03-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
2E8A	Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP 分子名称: Heat shock 70kDa protein 1A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-01-19 公開日 2008-01-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6H54	CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, GLYCEROL, ... 著者 Plank, C, Zehe, M, Grimm, C, Sotriffer, C. 登録日 2018-07-23 公開日 2019-08-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
2E88	Crystal structure of the human Hsp70 ATPase domain in the apo form 分子名称: Heat shock 70kDa protein 1A, ZINC ION 著者 Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-01-19 公開日 2008-01-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
7FGM	The complex crystals structure of the FAF1 UBL1_L-Hsp70 NBD with ADP and phosphate 分子名称: ADENOSINE-5'-DIPHOSPHATE, FAS-associated factor 1, Heat shock 70 kDa protein 1A, ... 著者 Kim, E.E, ParK, J.K, Shin, S.C. 登録日 2021-07-27 公開日 2022-07-27 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation J Mol Cell Biol, 14, 2022
7F4Z	X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1B, ... 著者 Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. 登録日 2021-06-21 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
7F50	X-ray crystal structure of Y149A mutated Hsp72-NBD in complex with AMPPnP 分子名称: CHLORIDE ION, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... 著者 Yokoyama, T, Fujii, S, Nabeshima, Y, Mizuguchi, M. 登録日 2021-06-21 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
7F4X	Joint neutron and X-ray crystal structure of the nucleotide-binding domain of Hsp72 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1B, MAGNESIUM ION, ... 著者 Yokoyama, T, Ostermann, A, Schrader, T.E. 登録日 2021-06-21 公開日 2022-06-29 最終更新日 2024-04-03 実験手法 NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION 主引用文献 Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP. Iucrj, 9, 2022
5FPD	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site. 分子名称: HEAT SHOCK-RELATED 70KDA PROTEIN 2, PYRAZINE-2-CARBOXAMIDE 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPM	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site. 分子名称: 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-12-02 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPE	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site. 分子名称: 3-AMINO-1,2,4-TRIAZOLE, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPN	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site. 分子名称: 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, HEAT SHOCK-RELATED 70 KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-12-02 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
1HPM	HOW POTASSIUM AFFECTS THE ACTIVITY OF THE MOLECULAR CHAPERONE HSC70. II. POTASSIUM BINDS SPECIFICALLY IN THE ATPASE ACTIVE SITE 分子名称: 44K ATPASE FRAGMENT (N-TERMINAL) OF 7O kD HEAT-SHOCK COGNATE PROTEIN, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Wilbanks, S.M, Mckay, D.B. 登録日 1995-03-24 公開日 1995-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 How potassium affects the activity of the molecular chaperone Hsc70. II. Potassium binds specifically in the ATPase active site. J.Biol.Chem., 270, 1995
6ASY	BiP-ATP2 分子名称: 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... 著者 Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. 登録日 2017-08-26 公開日 2017-12-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
6B1N	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
3GL1	Crystal structure of ATPase domain of Ssb1 chaperone, a member of the HSP70 family, from Saccharomyces cerevisiae 分子名称: CHLORIDE ION, GLYCEROL, Heat shock protein SSB1, ... 著者 Osipiuk, J, Li, H, Bargassa, M, Sahi, C, Craig, E.A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-03-11 公開日 2009-03-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystal structure of ATPase domain of Ssb1 chaperone, member of the HSP70 family from Saccharomyces cerevisiae. To be Published
6B1I	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
5GJJ	Glutathionylated hHsp70 SBD 分子名称: Heat shock 70 kDa protein 1A 著者 Gong, W.B, Yang, J, Zhang, H, Perrett, S. 登録日 2016-06-30 公開日 2017-07-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
6B1M	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: GLYCEROL, Heat shock protein family A (Hsp70) member 8, MAGNESIUM ION, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018

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