PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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2BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES 分子名称: DNAK 著者 Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. 登録日 1998-08-11 公開日 1999-03-02 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
4R5G	Crystal structure of the DnaK C-terminus with the inhibitor PET-16 分子名称: Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.4501 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5I	Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG 分子名称: Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ... 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9702 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
2BUP	T13G Mutant of the ATPASE fragment of Bovine HSC70 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Sousa, M.C, Mckay, D.B. 登録日 1998-09-08 公開日 1998-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry, 37, 1998
3QFP	Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain 分子名称: 78 kDa glucose-regulated protein homolog, PHOSPHATE ION 著者 Yan, M, Li, J.Z, Sha, B.D. 登録日 2011-01-22 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
1ATR	THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION, ... 著者 O'Brien, M.C, Mckay, D.B. 登録日 1993-08-09 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis. J.Biol.Chem., 268, 1993
1BA1	HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL MUTANT WITH CYS 17 REPLACED BY LYS 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ... 著者 Wilbanks, S.M, Mckay, D.B. 登録日 1998-04-21 公開日 1998-07-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry, 37, 1998
1ATS	THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION 著者 O'Brien, M.C, Mckay, D.B. 登録日 1993-08-09 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis. J.Biol.Chem., 268, 1993
3QFU	Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP 分子名称: 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Yan, M, Li, J.Z, Sha, B.D. 登録日 2011-01-22 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
3QNJ	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin 分子名称: Chaperone protein DnaK, SULFATE ION, antimicrobial peptide oncocin 著者 Zahn, M, Straeter, N. 登録日 2011-02-08 公開日 2011-03-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex. Chembiochem, 12, 2011
6B1N	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
1BA0	HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL 1NGE 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ... 著者 Wilbanks, S.M, Mckay, D.B. 登録日 1998-04-21 公開日 1998-07-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry, 37, 1998
6ASY	BiP-ATP2 分子名称: 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... 著者 Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. 登録日 2017-08-26 公開日 2017-12-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
6B1I	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
6B1M	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant 分子名称: GLYCEROL, Heat shock protein family A (Hsp70) member 8, MAGNESIUM ION, ... 著者 O'Donnell, J.P. 登録日 2017-09-18 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
2E8A	Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP 分子名称: Heat shock 70kDa protein 1A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-01-19 公開日 2008-01-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
2E88	Crystal structure of the human Hsp70 ATPase domain in the apo form 分子名称: Heat shock 70kDa protein 1A, ZINC ION 著者 Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-01-19 公開日 2008-01-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
5FPM	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site. 分子名称: 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-12-02 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5GJJ	Glutathionylated hHsp70 SBD 分子名称: Heat shock 70 kDa protein 1A 著者 Gong, W.B, Yang, J, Zhang, H, Perrett, S. 登録日 2016-06-30 公開日 2017-07-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
5FPE	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site. 分子名称: 3-AMINO-1,2,4-TRIAZOLE, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPD	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site. 分子名称: HEAT SHOCK-RELATED 70KDA PROTEIN 2, PYRAZINE-2-CARBOXAMIDE 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPN	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site. 分子名称: 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, HEAT SHOCK-RELATED 70 KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-12-02 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
3ATV	Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ... 著者 Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-01-13 公開日 2011-12-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
3ATU	Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ... 著者 Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-01-13 公開日 2011-12-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
3AY9	Crystal structure of human Hsp70 NBD in the ADP-, Mg ion-, and K ion-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... 著者 Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-05-03 公開日 2011-12-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011

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