PDB: 10530 件ウェブページステータス検索Chemie searchBIRD

---

1UHL	Crystal structure of the LXRalfa-RXRbeta LBD heterodimer 分子名称: (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID, 10-mer peptide from Nuclear receptor coactivator 2, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, ... 著者 Svensson, S, Ostberg, T, Jacobsson, M, Norstrom, C, Stefansson, K, Hallen, D, Johansson, I.C, Zachrisson, K, Ogg, D, Jendeberg, L. 登録日 2003-07-03 公開日 2004-06-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation Embo J., 22, 2003
3NCW	Crystal structure of EHEC O157:H7 intimin 分子名称: Intimin adherence protein 著者 Yi, Y, Gao, F, Gao, G.F, Zou, Q.M. 登録日 2010-06-06 公開日 2011-01-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of EHEC Intimin: Insights into the Complementarity between EPEC and EHEC Plos One, 5, 2010
3NBP	HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2 分子名称: 4-(4-{[4-(4-cyano-2,6-dimethylphenoxy)pyrimidin-2-yl]amino}piperidin-1-yl)benzenesulfonamide, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H, ... 著者 Harris, S.F, Villasenor, A.G. 登録日 2010-06-03 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg.Med.Chem.Lett., 20, 2010
2HCS	Crystal structure of RNA dependant RNA polymerase domain of West Nile virus 分子名称: RNA-directed RNA polymerase (NS5), ZINC ION 著者 Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2006-06-18 公開日 2007-02-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
3P3C	Crystal Structure of the Aquifex aeolicus LpxC/LPC-009 complex 分子名称: N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, PHOSPHATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... 著者 Lee, C.-J, Zhou, P. 登録日 2010-10-04 公開日 2011-01-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
2I7D	Structure of Human cytosolic deoxyribonucleotidase in complex with deoxyuridine, AlF4 and Mg2+ 分子名称: 2'-DEOXYURIDINE, 5'(3')-deoxyribonucleotidase, cytosolic type, ... 著者 Rinaldo-Matthis, A, Wallden, K, Nordlund, P. 登録日 2006-08-30 公開日 2007-10-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structures of Human and Murine cytosolic deoxyribonucleotidase: Insights into substrate specificity and catalysis To be Published
3ONR	Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site 分子名称: CALCIUM ION, FORMIC ACID, PLATINUM (II) ION, ... 著者 Arulandu, A, Sacchettini, J.C. 登録日 2010-08-30 公開日 2011-03-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site. Protein Sci., 20, 2011
4IKP	Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin 分子名称: (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ... 著者 Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-12-27 公開日 2013-02-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife, 8, 2019
2G46	structure of vSET in complex with meK27 H3 Pept. and cofactor product SAH 分子名称: PBCV-1 histone H3-Lys 27 methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, meK27 H3 Peptide 著者 Qian, C.M, Zheng, L, Zhou, M.M. 登録日 2006-02-21 公開日 2006-12-05 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase. J.Mol.Biol., 359, 2006
2HV5	Human Aldose Reductase complexed with inhibitor zopolrestat after three days soaking (3days_soaked_3) 分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Steuber, H, Heine, A, Klebe, G. 登録日 2006-07-27 公開日 2006-10-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions. J.Mol.Biol., 363, 2006
2HVN	Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation after one day (1day_cocryst) 分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Steuber, H, Heine, A, Klebe, G. 登録日 2006-07-29 公開日 2006-10-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions. J.Mol.Biol., 363, 2006
2HVO	Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation (10days_cocryst) 分子名称: 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Steuber, H, Heine, A, Klebe, G. 登録日 2006-07-29 公開日 2006-10-03 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Expect the unexpected or caveat for drug designers: multiple structure determinations using aldose reductase crystals treated under varying soaking and co-crystallisation conditions. J.Mol.Biol., 363, 2006
2I5O	Solution Structure of the Ubiquitin-Binding Zinc Finger (UBZ) Domain of the Human DNA Y-Polymerase Eta 分子名称: DNA polymerase eta, ZINC ION 著者 Zhou, P, Bomar, M.G. 登録日 2006-08-25 公開日 2007-03-13 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. Embo Rep., 8, 2007
1UPV	Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, OXYSTEROLS RECEPTOR LXR-BETA 著者 Hoerer, S, Schmid, A, Heckel, A, Budzinski, R.M, Nar, H. 登録日 2003-10-13 公開日 2004-10-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist J.Mol.Biol., 334, 2003
3P3E	Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex 分子名称: N-[(1S,2R)-2-hydroxy-1-(hydroxycarbamoyl)propyl]-4-(4-phenylbuta-1,3-diyn-1-yl)benzamide, NITRATE ION, SODIUM ION, ... 著者 Lee, C.-J, Zhou, P. 登録日 2010-10-04 公開日 2011-01-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design. Chem.Biol., 18, 2011
3O8H	EthR from Mycobacterium tuberculosis in complex with compound BDM14950 分子名称: 4-iodo-N-[(1-{2-oxo-2-[4-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]ethyl}-1H-1,2,3-triazol-4-yl)methyl]benzenesulfonamide, Transcriptional Regulatory Repressor protein (TETR-Family) EthR 著者 Willand, N, Desroses, M, Toto, P, Diri, B, Lens, Z, Villeret, V, Rucktooa, P, Locht, C, Baulard, A, Deprez, B. 登録日 2010-08-03 公開日 2010-09-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator. Acs Chem.Biol., 5, 2010
4INP	The crystal structure of Helicobacter pylori Ceue (HP1561) with Ni(II) bound 分子名称: ACETATE ION, Iron (III) ABC transporter, periplasmic iron-binding protein, ... 著者 Shaik, M.M, Cendron, L, Zanotti, G. 登録日 2013-01-05 公開日 2014-01-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Helicobacter pylori periplasmic receptor CeuE (HP1561) modulates its nickel affinity via organic metallophores. Mol.Microbiol., 91, 2014
3M24	Crystal structure of TagBFP fluorescent protein 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, GLYCEROL, ... 著者 Malashkevich, V.N, Subach, O.M, Almo, S.C, Verkhusha, V.V. 登録日 2010-03-06 公開日 2010-05-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins. Chem.Biol., 17, 2010
4IDJ	S.Aureus a-hemolysin monomer in complex with Fab 分子名称: Alpha-hemolysin, Fab Heavy chain, Fab Light chain, ... 著者 Strop, P. 登録日 2012-12-12 公開日 2013-06-26 最終更新日 2021-05-26 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus alpha-Hemolysin. J.Mol.Biol., 425, 2013
1UPW	Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, OXYSTEROLS RECEPTOR LXR-BETA 著者 Hoerer, S, Schmid, A, Heckel, A, Budzinski, R.M, Nar, H. 登録日 2003-10-13 公開日 2004-10-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist J.Mol.Biol., 334, 2003
2HCN	Crystal structure of RNA dependent RNA polymerase domain from west nile virus 分子名称: CALCIUM ION, RNA-directed RNA polymerase (NS5), ZINC ION 著者 Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP) 登録日 2006-06-17 公開日 2007-02-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5 J.Biol.Chem., 282, 2007
3P8H	Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist 分子名称: 3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]pyridine, GLYCEROL, Lethal(3)malignant brain tumor-like protein, ... 著者 Lam, R, Herold, J.M, Ouyang, H, Tempel, W, Gao, C, Ravichandran, M, Senisterra, G, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Kireev, D, Frye, S.V, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2010-10-13 公開日 2010-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Small-molecule ligands of methyl-lysine binding proteins. J.Med.Chem., 54, 2011
4GCJ	CDK2 in complex with inhibitor RC-3-89 分子名称: 1,2-ETHANEDIOL, 4-{[4-amino-5-(2-nitrobenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2012-07-30 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
4GL2	Structural Basis for dsRNA duplex backbone recognition by MDA5 分子名称: Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3'), ... 著者 Wu, B, Hur, S. 登録日 2012-08-13 公開日 2013-01-09 最終更新日 2013-02-06 実験手法 X-RAY DIFFRACTION (3.557 Å) 主引用文献 Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5. Cell(Cambridge,Mass.), 152, 2013
3PB5	Endothiapepsin in complex with a fragment 分子名称: Endothiapepsin, GLYCEROL, N-methyl-1-[5-(pyridin-3-yloxy)furan-2-yl]methanamine 著者 Koester, H, Heine, A, Klebe, G. 登録日 2010-10-20 公開日 2011-10-19 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes. J.Med.Chem., 54, 2011

<188189190191192193194195196197198199200201202203>