1UPW

Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist

Summary for 1UPW

Related1P8D 1PQ6 1PQ9 1PQC 1UPV
DescriptorOXYSTEROLS RECEPTOR LXR-BETA, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE (2 entities in total)
Functional Keywordsreceptor, nuclear hormone receptor, ligand binding domain, liver x receptor, transcription factor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  P55055
Total number of polymer chains1
Total molecular weight29897.95
Authors
Hoerer, S.,Schmid, A.,Heckel, A.,Budzinski, R.M.,Nar, H. (deposition date: 2003-10-13, release date: 2004-10-20, Last modification date: 2018-03-28)
Primary citation
Hoerer, S.,Schmid, A.,Heckel, A.,Budzinski, R.M.,Nar, H.
Crystal Structure of the Human Liver X Receptor Beta Ligand-Binding Domain in Complex with a Synthetic Agonist
J.Mol.Biol., 334:853-, 2003
PubMed: 14643652 (PDB entries with the same primary citation)
DOI: 10.1016/J.JMB.2003.10.033
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers10 0.4% 16.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25