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6F5E
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BU of 6f5e by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
分子名称: C-Jun-amino-terminal kinase-interacting protein 1, DD_D12_10_47, Mitogen-activated protein kinase 8
著者Wu, Y, Mittl, P.R, Honegger, A, Batyuk, A, Plueckthun, A.
登録日2017-12-01
公開日2017-12-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
To be published
2H96
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BU of 2h96 by Molmil
Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors
分子名称: 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE, C-jun-amino-terminal kinase-interacting protein 1, GLYCEROL, ...
著者Abad-Zapatero, C.
登録日2006-06-09
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
J.Med.Chem., 49, 2006
7QH6
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BU of 7qh6 by Molmil
Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 1
分子名称: 16S ribosomal RNA, 39S ribosomal protein L13, mitochondrial, ...
著者Rebelo-Guiomar, P, Pellegrino, S, Dent, K.C, Warren, A.J, Minczuk, M.
登録日2021-12-10
公開日2022-03-02
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Nat Commun, 13, 2022
4UZU
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BU of 4uzu by Molmil
Three-dimensional structure of a variant `Termamyl-like' Geobacillus stearothermophilus alpha-amylase at 1.9 A resolution
分子名称: ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION, ...
著者Offen, W.A, Anderson, C, Borchert, T.V, Wilson, K.S, Davies, G.J.
登録日2014-09-09
公開日2015-01-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Three-Dimensional Structure of a Variant `Termamyl-Like' Geobacillus Stearothermophilus Alpha-Amylase at 1.9 A Resolution
Acta Crystallogr.,Sect.F, 71, 2015
4V7L
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BU of 4v7l by Molmil
The structures of viomycin bound to the 70S ribosome.
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Stanley, R.E, Blaha, G.
登録日2009-11-12
公開日2014-07-09
最終更新日2018-07-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.
Nat.Struct.Mol.Biol., 17, 2010
7PO4
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BU of 7po4 by Molmil
Assembly intermediate of human mitochondrial ribosome large subunit (largely unfolded rRNA with MALSU1, L0R8F8 and ACP)
分子名称: 16SrRNA, 39S ribosomal protein L10, mitochondrial, ...
著者Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A.
登録日2021-09-08
公開日2022-06-15
最終更新日2023-11-15
実験手法ELECTRON MICROSCOPY (2.56 Å)
主引用文献Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
Nature, 606, 2022
6FUZ
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BU of 6fuz by Molmil
Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of JIP1
分子名称: GLYCEROL, Kinesin light chain 1,Kinesin light chain 1,C-Jun-amino-terminal kinase-interacting protein 1, nanobody
著者Pernigo, S, Dodding, M.P, Steiner, R.A.
登録日2018-02-28
公開日2018-05-02
最終更新日2019-09-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors.
Elife, 7, 2018
6GFJ
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BU of 6gfj by Molmil
Structure of RIP2 CARD domain fused to crystallisable MBP tag
分子名称: Sugar ABC transporter substrate-binding protein,Receptor-interacting serine/threonine-protein kinase 2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Pellegrini, E, Cusack, S.
登録日2018-04-30
公開日2019-03-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献RIP2 filament formation is required for NOD2 dependent NF-kappa B signalling.
Nat Commun, 9, 2018
6PW9
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BU of 6pw9 by Molmil
Cryo-EM structure of human NatE/HYPK complex
分子名称: ACETYL COENZYME *A, Huntingtin-interacting protein K, INOSITOL HEXAKISPHOSPHATE, ...
著者Deng, S, Marmorstein, R.
登録日2019-07-22
公開日2020-02-19
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (4.03 Å)
主引用文献Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK.
Nat Commun, 11, 2020
5HTO
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BU of 5hto by Molmil
Crystal structure of Plasmodium Vivax LDH in complex with a DNA aptamer called pL1 (tetrameric LDH in an asymmetric unit)
分子名称: DNA (30-MER), DNA (34-MER), L-lactate dehydrogenase, ...
著者Choi, S.J, Ban, C.
登録日2016-01-27
公開日2016-10-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition
Sci Rep, 6, 2016
5HRU
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BU of 5hru by Molmil
Crystal structure of Plasmodium vivax LDH in complex with a DNA aptamer called pL1
分子名称: DNA (32-MER), L-lactate dehydrogenase, MAGNESIUM ION
著者Choi, S.J, Ban, C.
登録日2016-01-24
公開日2016-10-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition
Sci Rep, 6, 2016
5HS4
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BU of 5hs4 by Molmil
Plasmdoium Vivax Lactate dehydrogenase
分子名称: L-lactate dehydrogenase
著者Choi, S.J, Ban, C.
登録日2016-01-25
公開日2016-10-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.339 Å)
主引用文献Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition
Sci Rep, 6, 2016
3CLJ
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BU of 3clj by Molmil
Structure of the RNA polymerase II CTD-interacting domain of Nrd1
分子名称: GLYCEROL, Protein NRD1, SULFATE ION
著者Vasiljeva, L, Kim, M, Mutschler, H, Buratowski, S, Meinhart, A.
登録日2008-03-19
公開日2008-07-29
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain.
Nat.Struct.Mol.Biol., 15, 2008
6LNM
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BU of 6lnm by Molmil
Crystal structure of CASK-CaMK in complex with Mint1-CID
分子名称: Amyloid-beta A4 precursor protein-binding family A member 1, Peripheral plasma membrane protein CASK
著者Cai, Q, Zhang, M.
登録日2019-12-31
公開日2020-04-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis for the High-Affinity Interaction between CASK and Mint1.
Structure, 28, 2020
1A22
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BU of 1a22 by Molmil
HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR
分子名称: GROWTH HORMONE, GROWTH HORMONE RECEPTOR
著者De Vos, A.M, Ultsch, M.
登録日1998-01-15
公開日1998-04-29
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity.
J.Mol.Biol., 277, 1998
3E1R
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BU of 3e1r by Molmil
Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55
分子名称: Centrosomal protein of 55 kDa, Programmed cell death 6-interacting protein
著者Lee, H.H, Elia, N, Ghirlando, R, Lippincott-Schwartz, J, Hurley, J.H.
登録日2008-08-04
公開日2008-11-04
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.
Science, 322, 2008
2ZL1
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BU of 2zl1 by Molmil
MP1-p14 Scaffolding complex
分子名称: Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein-binding protein-interacting protein
著者Schrag, J.D, Cygler, M, Munger, C, Magloire, A.
登録日2008-04-02
公開日2008-06-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular dynamics-solvated interaction energy studies of protein-protein interactions: the MP1-p14 scaffolding complex.
J.Mol.Biol., 379, 2008
3C3Q
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BU of 3c3q by Molmil
ALIX Bro1-domain:CHMIP4B co-crystal structure
分子名称: Charged multivesicular body protein 4b peptide, GLYCEROL, Programmed cell death 6-interacting protein
著者McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P.
登録日2008-01-28
公開日2008-06-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3C3R
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BU of 3c3r by Molmil
ALIX BRO1 CHMP4C complex
分子名称: Charged multivesicular body protein 4c peptide, GLYCEROL, Programmed cell death 6-interacting protein
著者McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P.
登録日2008-01-28
公開日2008-06-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3C3O
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BU of 3c3o by Molmil
ALIX Bro1-domain:CHMIP4A co-crystal structure
分子名称: Charged multivesicular body protein 4a peptide, GLYCEROL, Programmed cell death 6-interacting protein
著者McCullough, J.B, Fisher, R.D, Whitby, F.G, Sundquist, W.I, Hill, C.P.
登録日2008-01-28
公開日2008-06-10
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献ALIX-CHMP4 interactions in the human ESCRT pathway.
Proc.Natl.Acad.Sci.Usa, 105, 2008
7ABI
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BU of 7abi by Molmil
Human pre-Bact-2 spliceosome
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ...
著者Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
登録日2020-09-07
公開日2021-02-10
実験手法ELECTRON MICROSCOPY (8 Å)
主引用文献Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
5LA4
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BU of 5la4 by Molmil
Crystal structure of apo human proheparanase
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Heparanase, ...
著者Wu, L, Jin, Y, Davies, G.J.
登録日2016-06-13
公開日2017-05-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Activity-based probes for functional interrogation of retaining beta-glucuronidases.
Nat. Chem. Biol., 13, 2017
2KA1
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BU of 2ka1 by Molmil
Solution NMR structure of BNIP3 transmembrane peptide dimer in detergent micelles
分子名称: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
著者Sulistijo, E.S, MacKenzie, K.R.
登録日2008-10-30
公開日2009-06-23
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Structural basis for dimerization of the BNIP3 transmembrane domain
Biochemistry, 48, 2009
6TP5
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BU of 6tp5 by Molmil
Crystal structure of human Transmembrane prolyl 4-hydroxylase
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Myllykoski, M, Sutinen, A, Koski, M.K, Kallio, J.P, Raasakka, A, Myllyharju, J, Wierenga, R.K, Koivunen, P.
登録日2019-12-12
公開日2020-12-23
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.
J.Biol.Chem., 296, 2020
5L9Z
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BU of 5l9z by Molmil
Crystal structure of human heparanase nucleophile mutant (E343Q), in complex with unreacted glucuronic acid configured aziridine probe JJB355
分子名称: (1~{R},2~{S},3~{R},4~{S},5~{S},6~{R})-7-[8-[(azanylidene-{4}-azanylidene)amino]octyl]-3,4,5-tris(oxidanyl)-7-azabicyclo[4.1.0]heptane-2-carboxylic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wu, L, Jin, Y, Davies, G.J.
登録日2016-06-13
公開日2017-05-31
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Activity-based probes for functional interrogation of retaining beta-glucuronidases.
Nat. Chem. Biol., 13, 2017

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